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dc.contributor.authorBailey, S
dc.contributor.authorHamilton, W
dc.contributor.authorVan Melle, M
dc.contributor.authorYep Manzano, SIS
dc.contributor.authorWilson, H
dc.contributor.authorWalter, FM
dc.date.accessioned2020-04-20T07:48:28Z
dc.date.issued2020-05-07
dc.description.abstractBackground Recently, faecal immunochemical tests (FITs) have been introduced for investigation of primary care patients with low-risk symptoms of colorectal cancer (CRC), but recommendations vary across the world. This systematic review of clinical practice guidelines aimed to determine how FITs are used in symptomatic primary care patients and the underpinning evidence for these guidelines. Methods MEDLINE, Embase and TRIP databases were systematically searched, from 1 November 2008 to 1 November 2018 for guidelines on the assessment of patients with symptoms suggestive of CRC. Known guideline databases, websites and references of related literature were searched. The following questions were addressed: (i) which countries use FIT for symptomatic primary care patients; (ii) in which populations is FIT used; (iii) what is the cut-off level used for haemoglobin in the faeces (FIT) and (iv) on what evidence are FIT recommendations based. Results The search yielded 2433 publications; 25 covered initial diagnostic assessment of patients with symptoms of CRC in 15 countries (Asia, n = 1; Europe, n = 13; Oceania, n = 4; North America, n = 5; and South America, n = 2). In three countries (Australia, Spain and the UK), FIT was recommended for patients with abdominal symptoms, unexplained weight loss, change in bowel habit or anaemia despite a low level of evidence in the symptomatic primary care patient population. Conclusions Few countries recommend FITs in symptomatic patients in primary care either because of limited evidence or because symptomatic patients are directly referred to secondary care without triage. These results demonstrate a clear need for research on FIT in the symptomatic primary care population.en_GB
dc.description.sponsorshipCancer Research UKen_GB
dc.identifier.citationPublished online 7 May 2020en_GB
dc.identifier.doi10.1093/fampra/cmaa043
dc.identifier.grantnumberC8640/A23385en_GB
dc.identifier.urihttp://hdl.handle.net/10871/120728
dc.language.isoenen_GB
dc.publisherOxford University Press (OUP)en_GB
dc.rights.embargoreasonUnder embargo until 7 May 2021 in compliance with publisher policyen_GB
dc.rights© The Author(s) 2020. Published by Oxford University Press. All rights reserved
dc.subjectcancer care/oncologyen_GB
dc.subjectcanceren_GB
dc.subjectcolorectalen_GB
dc.subjectdiagnostic testsen_GB
dc.subjectprimary careen_GB
dc.subjectendoscopyen_GB
dc.subjectscreeningen_GB
dc.titleFaecal immunochemical test (FIT) to triage patients with abdominal symptoms for suspected colorectal cancer in primary care: review of international use and guidelinesen_GB
dc.typeArticleen_GB
dc.date.available2020-04-20T07:48:28Z
dc.identifier.issn0263-2136
dc.descriptionThis is the author accepted manuscript. The final version is available from Oxford University Press via the DOI in this recorden_GB
dc.identifier.journalFamily Practiceen_GB
dc.rights.urihttp://www.rioxx.net/licenses/all-rights-reserveden_GB
dcterms.dateAccepted2020-04-18
rioxxterms.versionAMen_GB
rioxxterms.licenseref.startdate2020-04-18
rioxxterms.typeJournal Article/Reviewen_GB
refterms.dateFCD2020-04-20T07:31:27Z
refterms.versionFCDAM
refterms.panelAen_GB


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