Mental health in UK Biobank - development, implementation and results from an online questionnaire completed by 157 366 participants: a reanalysis
dc.contributor.author | Davis, KAS | |
dc.contributor.author | Coleman, JRI | |
dc.contributor.author | Adams, M | |
dc.contributor.author | Allen, N | |
dc.contributor.author | Breen, G | |
dc.contributor.author | Cullen, B | |
dc.contributor.author | Dickens, C | |
dc.contributor.author | Fox, E | |
dc.contributor.author | Graham, N | |
dc.contributor.author | Holliday, J | |
dc.contributor.author | Howard, LM | |
dc.contributor.author | John, A | |
dc.contributor.author | Lee, W | |
dc.contributor.author | McCabe, R | |
dc.contributor.author | McIntosh, A | |
dc.contributor.author | Pearsall, R | |
dc.contributor.author | Smith, DJ | |
dc.contributor.author | Sudlow, C | |
dc.contributor.author | Ward, J | |
dc.contributor.author | Zammit, S | |
dc.contributor.author | Hotopf, M | |
dc.date.accessioned | 2020-04-28T12:45:23Z | |
dc.date.issued | 2020-02-06 | |
dc.description.abstract | Background UK Biobank is a well-characterised cohort of over 500 000 participants including genetics, environmental data and imaging. An online mental health questionnaire was designed for UK Biobank participants to expand its potential. Aims Describe the development, implementation and results of this questionnaire. Method An expert working group designed the questionnaire, using established measures where possible, and consulting a patient group. Operational criteria were agreed for defining likely disorder and risk states, including lifetime depression, mania/hypomania, generalised anxiety disorder, unusual experiences and self-harm, and current post-traumatic stress and hazardous/harmful alcohol use. Results A total of 157 366 completed online questionnaires were available by August 2017. Participants were aged 45–82 (53% were ≥65 years) and 57% women. Comparison of self-reported diagnosed mental disorder with a contemporary study shows a similar prevalence, despite respondents being of higher average socioeconomic status. Lifetime depression was a common finding, with 24% (37 434) of participants meeting criteria and current hazardous/harmful alcohol use criteria were met by 21% (32 602), whereas other criteria were met by less than 8% of the participants. There was extensive comorbidity among the syndromes. Mental disorders were associated with a high neuroticism score, adverse life events and long-term illness; addiction and bipolar affective disorder in particular were associated with measures of deprivation. Conclusions The UK Biobank questionnaire represents a very large mental health survey in itself, and the results presented here show high face validity, although caution is needed because of selection bias. Built into UK Biobank, these data intersect with other health data to offer unparalleled potential for crosscutting biomedical research involving mental health. | en_GB |
dc.description.sponsorship | National Institute for Health Research (NIHR) | en_GB |
dc.description.sponsorship | Wellcome Trust | en_GB |
dc.description.sponsorship | Scottish Executive Chief Scientist Office | en_GB |
dc.description.sponsorship | Dr Mortimer and Theresa Sackler Foundation | en_GB |
dc.description.sponsorship | European Union FP7 | en_GB |
dc.description.sponsorship | Farr Institute | en_GB |
dc.description.sponsorship | HCRW | en_GB |
dc.description.sponsorship | Lister Institute | en_GB |
dc.identifier.citation | Vol. 6 (2), article e18 | en_GB |
dc.identifier.doi | 10.1192/bjo.2019.100 | |
dc.identifier.grantnumber | 10436/Z/14/Z | en_GB |
dc.identifier.grantnumber | DTF/14/03 | en_GB |
dc.identifier.grantnumber | 324176 | en_GB |
dc.identifier.grantnumber | CA-04 | en_GB |
dc.identifier.grantnumber | 10436/Z/14/Z | en_GB |
dc.identifier.uri | http://hdl.handle.net/10871/120831 | |
dc.language.iso | en | en_GB |
dc.publisher | Cambridge University Press (CUP) / Royal College of Psychiatrists | en_GB |
dc.relation.url | http://hdl.handle.net/10871/31613 | en_GB |
dc.relation.url | https://doi.org/10.1192/bjo.2018.12 | en_GB |
dc.relation.url | http://doi.org/10.17632/kv677c2th4.3 | en_GB |
dc.rights | © The Author(s) 2020. This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited. | en_GB |
dc.subject | Mental health | en_GB |
dc.subject | UK Biobank | en_GB |
dc.subject | cohort study | en_GB |
dc.subject | depressive disorders | en_GB |
dc.subject | alcohol disorders | en_GB |
dc.title | Mental health in UK Biobank - development, implementation and results from an online questionnaire completed by 157 366 participants: a reanalysis | en_GB |
dc.type | Article | en_GB |
dc.date.available | 2020-04-28T12:45:23Z | |
dc.identifier.issn | 2056-4724 | |
exeter.article-number | ARTN e18 | en_GB |
dc.description | This is the final version. Available on open access from Cambridge University Press via the DOI in this record | en_GB |
dc.description | Note that the original version of this article was subsequently retracted and is available in ORE at http://hdl.handle.net/10871/31613 | en_GB |
dc.description | Data availability: Available from UK Biobank subject to standard procedures (www.ukbiobank.ac.uk). Code for replication available from Mendeley Data (http://doi.org/10.17632/kv677c2th4.3). | en_GB |
dc.identifier.journal | BJPsych Open | en_GB |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | en_GB |
dcterms.dateAccepted | 2019-12-17 | |
rioxxterms.version | VoR | en_GB |
rioxxterms.licenseref.startdate | 2020-02-06 | |
rioxxterms.type | Journal Article/Review | en_GB |
refterms.dateFCD | 2020-04-28T12:38:18Z | |
refterms.versionFCD | VoR | |
refterms.dateFOA | 2020-04-28T12:45:32Z | |
refterms.panel | A | en_GB |
refterms.depositException | publishedGoldOA |
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This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.