The characteristics of patients with possible Transient Ischemic Attack and Minor Stroke in the Hunter and Manning Valley regions, Australia (the INSIST Study)
dc.contributor.author | Tomari, S | |
dc.contributor.author | Magin, P | |
dc.contributor.author | Lasserson, D | |
dc.contributor.author | Quain, D | |
dc.contributor.author | Valderas, JM | |
dc.contributor.author | Dewey, HM | |
dc.contributor.author | Barber, PA | |
dc.contributor.author | Spratt, NJ | |
dc.contributor.author | Cadilhac, DA | |
dc.contributor.author | Feigin, VL | |
dc.contributor.author | Rothwell, PM | |
dc.contributor.author | Zareie, H | |
dc.contributor.author | Garcia-Esperon, C | |
dc.contributor.author | Davey, A | |
dc.contributor.author | Najib, N | |
dc.contributor.author | Sales, M | |
dc.contributor.author | Levi, CR | |
dc.date.accessioned | 2020-06-12T13:44:02Z | |
dc.date.issued | 2020-05-15 | |
dc.description.abstract | Background: Transient ischemic attack (TIA) and minor stroke (TIAMS) are risk factors for stroke recurrence. Some TIAMS may be preventable by appropriate primary prevention. We aimed to recruit “possible-TIAMS” patients in the INternational comparison of Systems of care and patient outcomes In minor Stroke and TIA (INSIST) study. Methods: A prospective inception cohort study performed across 16 Hunter–Manning region, Australia, general practices in the catchment of one secondary-care acute neurovascular clinic. Possible-TIAMS patients were recruited from August 2012 to August 2016. We describe the baseline demographics, risk factors and pre-event medications of participating patients. Results: There were 613 participants (mean age; 69 ± 12 years, 335 women), and 604 (99%) were Caucasian. Hypertension was the most common risk factor (69%) followed by hyperlipidemia (52%), diabetes mellitus (17%), atrial fibrillation (AF) (17%), prior TIA (13%) or stroke (10%). Eighty-nine (36%) of the 249 participants taking antiplatelet therapy had no known history of cardiovascular morbidity. Of 102 participants with known AF, 91 (89%) had a CHA2DS2-VASc score ≥ 2 but only 47 (46%) were taking anticoagulation therapy. Among 304 participants taking an antiplatelet or anticoagulant agent, 30 (10%) had stopped taking these in the month prior to the index event. Conclusion: This study provides the first contemporary data on TIAMS or TIAMS-mimics in Australia. Community and health provider education is required to address the under-use of anticoagulation therapy in patients with known AF, possibly inappropriate use of antiplatelet therapy and possibly inappropriate discontinuation of antiplatelet or anticoagulation therapy. | en_GB |
dc.description.sponsorship | National Health and Medical Research Council | en_GB |
dc.identifier.citation | Vol. 11, article 383 | en_GB |
dc.identifier.doi | 10.3389/fneur.2020.00383 | |
dc.identifier.grantnumber | 1027794 | en_GB |
dc.identifier.uri | http://hdl.handle.net/10871/121403 | |
dc.language.iso | en | en_GB |
dc.publisher | American Academy of Neurology | en_GB |
dc.rights | © 2020 Tomari, Magin, Lasserson, Quain, Valderas, Dewey, Barber, Spratt, Cadilhac, Feigin, Rothwell, Zareie, Garcia-Esperon, Davey, Najib, Sales and Levi. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. | en_GB |
dc.subject | transient ischemic attack | en_GB |
dc.subject | minor stroke | en_GB |
dc.subject | stroke-mimic syndrome | en_GB |
dc.subject | atrial fibrillation | en_GB |
dc.subject | anticoagulation therapy | en_GB |
dc.title | The characteristics of patients with possible Transient Ischemic Attack and Minor Stroke in the Hunter and Manning Valley regions, Australia (the INSIST Study) | en_GB |
dc.type | Article | en_GB |
dc.date.available | 2020-06-12T13:44:02Z | |
dc.identifier.issn | 0028-3878 | |
dc.description | This is the final version. Available on open access from the American Academy of Neurology via the DOI in this record. | en_GB |
dc.identifier.eissn | 1526-632X | |
dc.identifier.journal | Frontiers in Neurology | en_GB |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | en_GB |
dcterms.dateAccepted | 2020-04-15 | |
rioxxterms.version | VoR | en_GB |
rioxxterms.licenseref.startdate | 2020-04-15 | |
rioxxterms.type | Journal Article/Review | en_GB |
refterms.dateFCD | 2020-06-12T13:37:53Z | |
refterms.versionFCD | VoR | |
refterms.dateFOA | 2020-06-12T13:44:05Z | |
refterms.panel | A | en_GB |
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Except where otherwise noted, this item's licence is described as © 2020 Tomari, Magin, Lasserson, Quain, Valderas, Dewey, Barber, Spratt, Cadilhac, Feigin, Rothwell, Zareie, Garcia-Esperon, Davey, Najib, Sales and Levi. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.