Adherence and persistence to direct oral anticoagulants in atrial fibrillation: A population-based study
dc.contributor.author | Banerjee, A | |
dc.contributor.author | Benedetto, V | |
dc.contributor.author | Gichuru, P | |
dc.contributor.author | Burnell, J | |
dc.contributor.author | Antoniou, S | |
dc.contributor.author | Schilling, RJ | |
dc.contributor.author | Strain, WD | |
dc.contributor.author | Ryan, R | |
dc.contributor.author | Watkins, C | |
dc.contributor.author | Marshall, T | |
dc.contributor.author | Sutton, CJ | |
dc.date.accessioned | 2020-06-18T12:56:47Z | |
dc.date.issued | 2019-10-10 | |
dc.description.abstract | Background Despite simpler regimens than vitamin K antagonists (VKAs) for stroke prevention in atrial fibrillation (AF), adherence (taking drugs as prescribed) and persistence (continuation of drugs) to direct oral anticoagulants are suboptimal, yet understudied in electronic health records (EHRs). Objective We investigated (1) time trends at individual and system levels, and (2) the risk factors for and associations between adherence and persistence. Methods In UK primary care EHR (The Health Information Network 2011-2016), we investigated adherence and persistence at 1 year for oral anticoagulants (OACs) in adults with incident AF. Baseline characteristics were analysed by OAC and adherence/persistence status. Risk factors for non-adherence and non-persistence were assessed using Cox and logistic regression. Patterns of adherence and persistence were analysed. Results Among 36 652 individuals with incident AF, cardiovascular comorbidities (median CHA 2 DS 2 VASc[Congestive heart failure, Hypertension, Age≥75 years, Diabetes mellitus, Stroke, Vascular disease, Age 65-74 years, Sex category] 3) and polypharmacy (median number of drugs 6) were common. Adherence was 55.2% (95% CI 54.6 to 55.7), 51.2% (95% CI 50.6 to 51.8), 66.5% (95% CI 63.7 to 69.2), 63.1% (95% CI 61.8 to 64.4) and 64.7% (95% CI 63.2 to 66.1) for all OACs, VKA, dabigatran, rivaroxaban and apixaban. One-year persistence was 65.9% (95% CI 65.4 to 66.5), 63.4% (95% CI 62.8 to 64.0), 61.4% (95% CI 58.3 to 64.2), 72.3% (95% CI 70.9 to 73.7) and 78.7% (95% CI 77.1 to 80.1) for all OACs, VKA, dabigatran, rivaroxaban and apixaban. Risk of non-adherence and non-persistence increased over time at individual and system levels. Increasing comorbidity was associated with reduced risk of non-adherence and non-persistence across all OACs. Overall rates of 'primary non-adherence' (stopping after first prescription), 'non-adherent non-persistence' and 'persistent adherence' were 3.5%, 26.5% and 40.2%, differing across OACs. Conclusions Adherence and persistence to OACs are low at 1 year with heterogeneity across drugs and over time at individual and system levels. Better understanding of contributory factors will inform interventions to improve adherence and persistence across OACs in individuals and populations. | en_GB |
dc.description.sponsorship | European Union FP7 | en_GB |
dc.description.sponsorship | National Institute for Health Research (NIHR) | en_GB |
dc.identifier.citation | Vol. 106, pp. 119 - 126 | en_GB |
dc.identifier.doi | 10.1136/heartjnl-2019-315307 | |
dc.identifier.grantnumber | 339239 | en_GB |
dc.identifier.uri | http://hdl.handle.net/10871/121516 | |
dc.language.iso | en | en_GB |
dc.publisher | BMJ Publishing Group with British Cardiovascular Society | en_GB |
dc.rights | © Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/. | en_GB |
dc.title | Adherence and persistence to direct oral anticoagulants in atrial fibrillation: A population-based study | en_GB |
dc.type | Article | en_GB |
dc.date.available | 2020-06-18T12:56:47Z | |
dc.identifier.issn | 1355-6037 | |
dc.description | This is the final version. Available on open access from BMJ Publishing Group via the DOI in this record | en_GB |
dc.description | Data availability statement: THIN data are available upon application after Scientific Review Committee (SRC) approval through a licenced organisation. Data are not publicly available. | en_GB |
dc.identifier.journal | Heart | en_GB |
dc.rights.uri | https://creativecommons.org/licenses/by-nc/4.0/ | en_GB |
dcterms.dateAccepted | 2019-08-29 | |
rioxxterms.version | VoR | en_GB |
rioxxterms.licenseref.startdate | 2019-10-10 | |
rioxxterms.type | Journal Article/Review | en_GB |
refterms.dateFCD | 2020-06-18T12:53:43Z | |
refterms.versionFCD | VoR | |
refterms.dateFOA | 2020-06-18T12:56:51Z | |
refterms.panel | A | en_GB |
refterms.depositException | publishedGoldOA |
Files in this item
This item appears in the following Collection(s)
Except where otherwise noted, this item's licence is described as © Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.