Pharmacological treatment for Type 2 diabetes integrating findings from cardiovascular outcome trials: an expert consensus in the UK
dc.contributor.author | Bain, SC | |
dc.contributor.author | Bakhai, A | |
dc.contributor.author | Evans, M | |
dc.contributor.author | Green, A | |
dc.contributor.author | Menown, I | |
dc.contributor.author | Strain, WD | |
dc.date.accessioned | 2020-06-18T13:08:11Z | |
dc.date.issued | 2019-06-29 | |
dc.description.abstract | In people with Type 2 diabetes, cardiovascular disease is a leading cause of morbidity and mortality. Thus, as well as controlling glucose, reducing the risk of cardiovascular events is a key goal. The results of cardiovascular outcome trials have led to updates for many national and international guidelines. England, Wales and Northern Ireland remain exceptions, with the most recent update to the National Institute for Health and Care Excellence (NICE) guidelines published in 2015. We reviewed current national and international guidelines and recommendations on the management of people with Type 2 diabetes. This article shares our consensus on clinical recommendations for the use of sodium-glucose co-transporter 2 inhibitors (SGLT-2is) and glucagon-like peptide 1 receptor agonists (GLP-1RAs) in people with Type 2 diabetes and established or at very high risk of cardiovascular disease in the UK. We also consider cost-effectiveness for these therapies. We recommend considering each person's cardiovascular risk and using diabetes therapies with proven cardiovascular benefits when appropriate to improve long-term outcomes and cost-effectiveness. | en_GB |
dc.description.sponsorship | Novo Nordisk | en_GB |
dc.identifier.citation | Vol. 36 (9), pp. 1063 - 1071 | en_GB |
dc.identifier.doi | 10.1111/dme.14058 | |
dc.identifier.uri | http://hdl.handle.net/10871/121517 | |
dc.language.iso | en | en_GB |
dc.publisher | Wiley for Diabetes UK | en_GB |
dc.rights | © 2019 The Authors. Diabetic Medicine published by John Wiley & Sons Ltd on behalf of Diabetes UK. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. | en_GB |
dc.title | Pharmacological treatment for Type 2 diabetes integrating findings from cardiovascular outcome trials: an expert consensus in the UK | en_GB |
dc.type | Article | en_GB |
dc.date.available | 2020-06-18T13:08:11Z | |
dc.identifier.issn | 0742-3071 | |
dc.description | This is the final version. Available on open access from Wiley via the DOI in this record | en_GB |
dc.identifier.journal | Diabetic Medicine | en_GB |
dc.rights.uri | https://creativecommons.org/licenses/by-nc/4.0/ | en_GB |
dcterms.dateAccepted | 2019-06-27 | |
rioxxterms.version | VoR | en_GB |
rioxxterms.licenseref.startdate | 2019-06-27 | |
rioxxterms.type | Journal Article/Review | en_GB |
refterms.dateFCD | 2020-06-18T13:04:12Z | |
refterms.versionFCD | VoR | |
refterms.dateFOA | 2020-06-18T13:08:15Z | |
refterms.panel | A | en_GB |
refterms.depositException | publishedGoldOA |
Files in this item
This item appears in the following Collection(s)
Except where otherwise noted, this item's licence is described as © 2019 The Authors. Diabetic Medicine published by John Wiley & Sons Ltd on behalf of Diabetes UK.
This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.