Measurement of Wall Shear Stress Exerted by Flowing Blood in the Human Carotid Artery: Ultrasound Doppler Velocimetry and Echo Particle Image Velocimetry
dc.contributor.author | Gates, PE | |
dc.contributor.author | Gurung, A | |
dc.contributor.author | Mazzaro, L | |
dc.contributor.author | Aizawa, K | |
dc.contributor.author | Elyas, S | |
dc.contributor.author | Strain, WD | |
dc.contributor.author | Shore, AC | |
dc.contributor.author | Shandas, R | |
dc.date.accessioned | 2020-06-18T14:16:15Z | |
dc.date.issued | 2018-04-17 | |
dc.description.abstract | Vascular endothelial cells lining the arteries are sensitive to wall shear stress (WSS) exerted by flowing blood. An important component of the pathophysiology of vascular diseases, WSS is commonly estimated by centerline ultrasound Doppler velocimetry (UDV). However, the accuracy of this method is uncertain. We have previously validated the use of a novel, ultrasound-based, particle image velocimetry technique (echo PIV) to compute 2-D velocity vector fields, which can easily be converted into WSS data. We compared WSS data derived from UDV and echo PIV in the common carotid artery of 27 healthy participants. Compared with echo PIV, time-averaged WSS was lower using UDV (28 ± 35%). Echo PIV revealed that this was due to considerable spatiotemporal variation in the flow velocity profile, contrary to the assumption that flow is steady and the velocity profile is parabolic throughout the cardiac cycle. The largest WSS underestimation by UDV was found during peak systole (118 ± 16%) and the smallest during mid-diastole (4.3± 46%). The UDV method underestimated WSS for the accelerating and decelerating systolic measurements (68 ± 30% and 24 ± 51%), whereas WSS was overestimated for end-diastolic measurements (−44 ± 55%). Our data indicate that UDV estimates of WSS provided limited and largely inaccurate information about WSS and that the complex spatiotemporal flow patterns do not fit well with traditional assumptions about blood flow in arteries. Echo PIV-derived WSS provides detailed information about this important but poorly understood stimulus that influences vascular endothelial pathophysiology. | en_GB |
dc.description.sponsorship | National Institute of Health | en_GB |
dc.description.sponsorship | National Institute for Health Research (NIHR) | en_GB |
dc.identifier.citation | Vol. 44 (7), pp. 1392 - 1401 | en_GB |
dc.identifier.doi | 10.1016/j.ultrasmedbio.2018.02.013 | |
dc.identifier.grantnumber | NIH T32 HL-727238 | en_GB |
dc.identifier.grantnumber | K24- HL081506 RO1-HL114753 | en_GB |
dc.identifier.uri | http://hdl.handle.net/10871/121523 | |
dc.language.iso | en | en_GB |
dc.publisher | Elsevier for World Federation for Ultrasound in Medicine and Biology | en_GB |
dc.rights | © 2018. This version is made available under the CC-BY-NC-ND 4.0 license: https://creativecommons.org/licenses/by-nc-nd/4.0/ | en_GB |
dc.subject | Ultrasound | en_GB |
dc.subject | Echo particle image velocimetry | en_GB |
dc.subject | Ultrasound imaging velocimetry | en_GB |
dc.subject | Blood flow | en_GB |
dc.subject | Hemodynamics | en_GB |
dc.subject | Vascular | en_GB |
dc.title | Measurement of Wall Shear Stress Exerted by Flowing Blood in the Human Carotid Artery: Ultrasound Doppler Velocimetry and Echo Particle Image Velocimetry | en_GB |
dc.type | Article | en_GB |
dc.date.available | 2020-06-18T14:16:15Z | |
dc.identifier.issn | 0301-5629 | |
dc.description | This is the author accepted manuscript. The final version is available from Elsevier via the DOI in this record | en_GB |
dc.identifier.journal | Ultrasound in Medicine and Biology | en_GB |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | en_GB |
dcterms.dateAccepted | 2018-02-26 | |
rioxxterms.version | AM | en_GB |
rioxxterms.licenseref.startdate | 2018-02-26 | |
rioxxterms.type | Journal Article/Review | en_GB |
refterms.dateFCD | 2020-06-18T14:11:38Z | |
refterms.versionFCD | AM | |
refterms.dateFOA | 2020-06-18T14:16:19Z | |
refterms.panel | A | en_GB |
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Except where otherwise noted, this item's licence is described as © 2018. This version is made available under the CC-BY-NC-ND 4.0 license: https://creativecommons.org/licenses/by-nc-nd/4.0/