Adapting to survive: How Candida overcomes host-imposed constraints during human colonization
dc.contributor.author | Alves, R | |
dc.contributor.author | Barata-Antunes, C | |
dc.contributor.author | Casal, M | |
dc.contributor.author | Brown, AJP | |
dc.contributor.author | van Dijck, P | |
dc.contributor.author | Paiva, S | |
dc.date.accessioned | 2020-07-06T10:24:33Z | |
dc.date.issued | 2020-05-21 | |
dc.description.abstract | Successful human colonizers such as Candida pathogens have evolved distinct strategies to survive and proliferate within the human host. These include sophisticated mechanisms to evade immune surveillance and adapt to constantly changing host microenvironments where nutrient limitation, pH fluctuations, oxygen deprivation, changes in temperature, or exposure to oxidative, nitrosative, and cationic stresses may occur. Here, we review the current knowledge and recent findings highlighting the remarkable ability of medically important Candida species to overcome a broad range of host-imposed constraints and how this directly affects their physiology and pathogenicity. We also consider the impact of these adaptation mechanisms on immune recognition, biofilm formation, and antifungal drug resistance, as these pathogens often exploit specific host constraints to establish a successful infection. Recent studies of adaptive responses to physiological niches have improved our understanding of the mechanisms established by fungal pathogens to evade the immune system and colonize the host, which may facilitate the design of innovative diagnostic tests and therapeutic approaches for Candida infections. | en_GB |
dc.description.sponsorship | FCT | en_GB |
dc.description.sponsorship | Boehringer Ingelheim Fonds | en_GB |
dc.description.sponsorship | KU Leuven | en_GB |
dc.description.sponsorship | MRC | en_GB |
dc.description.sponsorship | Wellcome Trust | en_GB |
dc.identifier.citation | Vol. 16 (5), e1008478 | en_GB |
dc.identifier.doi | 10.1371/journal.ppat.1008478 | |
dc.identifier.grantnumber | UIBD/04050/2020 | en_GB |
dc.identifier.grantnumber | PD/BD/113813/2015 | en_GB |
dc.identifier.grantnumber | PD/BD/135208/2017 | en_GB |
dc.identifier.grantnumber | G0F8519N | en_GB |
dc.identifier.grantnumber | C14/17/063 | en_GB |
dc.identifier.grantnumber | MR/M026663/1 | en_GB |
dc.identifier.grantnumber | MR/N006364/1 | en_GB |
dc.identifier.grantnumber | 097377 | en_GB |
dc.identifier.uri | http://hdl.handle.net/10871/121792 | |
dc.language.iso | en | en_GB |
dc.publisher | Public Library of Science | en_GB |
dc.rights | Copyright © 2020 Alves et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | en_GB |
dc.title | Adapting to survive: How Candida overcomes host-imposed constraints during human colonization | en_GB |
dc.type | Article | en_GB |
dc.date.available | 2020-07-06T10:24:33Z | |
dc.identifier.issn | 1553-7366 | |
dc.description | This is the final version. Available from Public Library of Science via the DOI in this record. | en_GB |
dc.identifier.journal | PLoS pathogens | en_GB |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | en_GB |
dcterms.dateAccepted | 2020-05-21 | |
rioxxterms.version | VoR | en_GB |
rioxxterms.licenseref.startdate | 2020-05-21 | |
rioxxterms.type | Journal Article/Review | en_GB |
refterms.dateFCD | 2020-07-06T10:15:17Z | |
refterms.versionFCD | VoR | |
refterms.dateFOA | 2020-07-06T10:24:38Z | |
refterms.panel | A | en_GB |
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Except where otherwise noted, this item's licence is described as Copyright © 2020 Alves et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.