Maintaining social contacts: The physiological relevance of organelle interactions
dc.contributor.author | Silva, BSC | |
dc.contributor.author | DiGiovanni, L | |
dc.contributor.author | Kumar, R | |
dc.contributor.author | Carmichael, RE | |
dc.contributor.author | Kim, PK | |
dc.contributor.author | Schrader, M | |
dc.date.accessioned | 2020-07-22T10:54:21Z | |
dc.date.issued | 2020-07-23 | |
dc.description.abstract | Membrane-bound organelles in eukaryotic cells form an interactive network to coordinate and facilitate cellular functions. The formation of close contacts, termed “membrane contact sites” (MCSs), represents an intriguing strategy for organelle interaction and coordinated interplay. Emerging research is rapidly revealing new details of MCSs. They represent ubiquitous and diverse structures, which are important for many aspects of cell physiology and homeostasis. Here, we provide a comprehensive overview of the physiological relevance of organelle contacts. We focus on mitochondria, peroxisomes, the Golgi complex and the plasma membrane, and discuss the most recent findings on their interactions with other subcellular organelles and their multiple functions, including membrane contacts with the ER, lipid droplets and the endosomal/lysosomal compartment. | en_GB |
dc.description.sponsorship | Biotechnology & Biological Sciences Research Council (BBSRC) | en_GB |
dc.description.sponsorship | European Commission | en_GB |
dc.identifier.citation | Article 118800 | en_GB |
dc.identifier.grantnumber | 812968 | en_GB |
dc.identifier.grantnumber | BB/T002255/1 | en_GB |
dc.identifier.uri | http://hdl.handle.net/10871/122072 | |
dc.language.iso | en | en_GB |
dc.publisher | Elsevier | en_GB |
dc.rights | © 2020. Open access under a Creative Commons license: https://creativecommons.org/licenses/by/4.0/ | en_GB |
dc.subject | Acyl-CoA binding domain containing protein | en_GB |
dc.subject | peroxisomes | en_GB |
dc.subject | mitochondria | en_GB |
dc.subject | lipid metabolism | en_GB |
dc.subject | membrane contact sites | en_GB |
dc.subject | FFAT motif | en_GB |
dc.title | Maintaining social contacts: The physiological relevance of organelle interactions | en_GB |
dc.type | Article | en_GB |
dc.date.available | 2020-07-22T10:54:21Z | |
dc.identifier.issn | 0167-4889 | |
dc.description | This is the author accepted manuscript. The final version is available on open access from Elsevier via the DOI in this record | en_GB |
dc.identifier.journal | Biochimica et Biophysica Acta (BBA) - Molecular Cell Research | en_GB |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | en_GB |
dcterms.dateAccepted | 2020-07-19 | |
exeter.funder | ::Biotechnology & Biological Sciences Research Council (BBSRC) | en_GB |
exeter.funder | ::Biotechnology & Biological Sciences Research Council (BBSRC) | en_GB |
exeter.funder | ::European Commission | en_GB |
exeter.funder | ::Biotechnology & Biological Sciences Research Council (BBSRC) | en_GB |
rioxxterms.version | AM | en_GB |
rioxxterms.licenseref.startdate | 2020-07-19 | |
rioxxterms.type | Journal Article/Review | en_GB |
refterms.dateFCD | 2020-07-21T16:40:40Z | |
refterms.versionFCD | AM | |
refterms.dateFOA | 2020-08-03T14:03:15Z | |
refterms.panel | A | en_GB |
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