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dc.contributor.authorSilva, BSC
dc.contributor.authorDiGiovanni, L
dc.contributor.authorKumar, R
dc.contributor.authorCarmichael, RE
dc.contributor.authorKim, PK
dc.contributor.authorSchrader, M
dc.date.accessioned2020-07-22T10:54:21Z
dc.date.issued2020-07-23
dc.description.abstractMembrane-bound organelles in eukaryotic cells form an interactive network to coordinate and facilitate cellular functions. The formation of close contacts, termed “membrane contact sites” (MCSs), represents an intriguing strategy for organelle interaction and coordinated interplay. Emerging research is rapidly revealing new details of MCSs. They represent ubiquitous and diverse structures, which are important for many aspects of cell physiology and homeostasis. Here, we provide a comprehensive overview of the physiological relevance of organelle contacts. We focus on mitochondria, peroxisomes, the Golgi complex and the plasma membrane, and discuss the most recent findings on their interactions with other subcellular organelles and their multiple functions, including membrane contacts with the ER, lipid droplets and the endosomal/lysosomal compartment.en_GB
dc.description.sponsorshipBiotechnology & Biological Sciences Research Council (BBSRC)en_GB
dc.description.sponsorshipEuropean Commissionen_GB
dc.identifier.citationArticle 118800en_GB
dc.identifier.grantnumber812968en_GB
dc.identifier.grantnumberBB/T002255/1en_GB
dc.identifier.urihttp://hdl.handle.net/10871/122072
dc.language.isoenen_GB
dc.publisherElsevieren_GB
dc.rights© 2020. Open access under a Creative Commons license: https://creativecommons.org/licenses/by/4.0/en_GB
dc.subjectAcyl-CoA binding domain containing proteinen_GB
dc.subjectperoxisomesen_GB
dc.subjectmitochondriaen_GB
dc.subjectlipid metabolismen_GB
dc.subjectmembrane contact sitesen_GB
dc.subjectFFAT motifen_GB
dc.titleMaintaining social contacts: The physiological relevance of organelle interactionsen_GB
dc.typeArticleen_GB
dc.date.available2020-07-22T10:54:21Z
dc.identifier.issn0167-4889
dc.descriptionThis is the author accepted manuscript. The final version is available on open access from Elsevier via the DOI in this recorden_GB
dc.identifier.journalBiochimica et Biophysica Acta (BBA) - Molecular Cell Researchen_GB
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en_GB
dcterms.dateAccepted2020-07-19
exeter.funder::Biotechnology & Biological Sciences Research Council (BBSRC)en_GB
exeter.funder::Biotechnology & Biological Sciences Research Council (BBSRC)en_GB
exeter.funder::European Commissionen_GB
exeter.funder::Biotechnology & Biological Sciences Research Council (BBSRC)en_GB
rioxxterms.versionAMen_GB
rioxxterms.licenseref.startdate2020-07-19
rioxxterms.typeJournal Article/Reviewen_GB
refterms.dateFCD2020-07-21T16:40:40Z
refterms.versionFCDAM
refterms.dateFOA2020-08-03T14:03:15Z
refterms.panelAen_GB


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© 2020. Open access under a Creative Commons license: https://creativecommons.org/licenses/by/4.0/
Except where otherwise noted, this item's licence is described as © 2020. Open access under a Creative Commons license: https://creativecommons.org/licenses/by/4.0/