Clinical Practice Guideline for Systemic Antifungal Prophylaxis in Pediatric Patients With Cancer and Hematopoietic Stem-Cell Transplantation Recipients
dc.contributor.author | Lehrnbecher, T | |
dc.contributor.author | Fisher, BT | |
dc.contributor.author | Phillips, B | |
dc.contributor.author | Beauchemin, M | |
dc.contributor.author | Carlesse, F | |
dc.contributor.author | Castagnola, E | |
dc.contributor.author | Duong, N | |
dc.contributor.author | Dupuis, LL | |
dc.contributor.author | Fioravantti, V | |
dc.contributor.author | Groll, AH | |
dc.contributor.author | Haeusler, GM | |
dc.contributor.author | Roilides, E | |
dc.contributor.author | Science, M | |
dc.contributor.author | Steinbach, WJ | |
dc.contributor.author | Tissing, W | |
dc.contributor.author | Warris, A | |
dc.contributor.author | Patel, P | |
dc.contributor.author | Robinson, PD | |
dc.contributor.author | Sung, L | |
dc.date.accessioned | 2020-08-18T10:12:18Z | |
dc.date.issued | 2020-05-27 | |
dc.description.abstract | PURPOSE: To develop a clinical practice guideline for systemic antifungal prophylaxis in pediatric patients with cancer and hematopoietic stem-cell transplantation (HSCT) recipients. METHODS: Recommendations were developed by an international multidisciplinary panel that included a patient advocate. We conducted a systematic review of systemic antifungal prophylaxis in children and adults with cancer and HSCT recipients. The Grading of Recommendations Assessment, Development, and Evaluation approach was used to make strong or weak recommendations and to classify level of evidence as high, moderate, low, or very low. The panel considered directness of the data to pediatric patients. RESULTS: There were 68 randomized trials included in the systematic review, of which 6 (9%) were conducted in a solely pediatric population. Strong recommendations were made to administer systemic antifungal prophylaxis to children and adolescents receiving treatment of acute myeloid leukemia, to those undergoing allogeneic HSCT pre-engraftment, and to those receiving systemic immunosuppression for graft-versus-host disease treatment. A strong recommendation was made to administer a mold-active agent with an echinocandin or a mold-active azole when systemic antifungal prophylaxis is warranted. For children younger than 13 years of age, an echinocandin, voriconazole, or itraconazole is suggested. Posaconazole may also be used in those age 13 years or older. A strong recommendation against routine administration of amphotericin as systemic antifungal prophylaxis was made. CONCLUSION: We developed a clinical practice guideline for systemic antifungal prophylaxis administration in pediatric patients with cancer and HSCT recipients. Implementation and assessment of guideline-concordant rates and impacts are important future steps. | en_GB |
dc.description.sponsorship | Pediatric Oncology Group of Ontario | en_GB |
dc.description.sponsorship | Wellcome Trust | en_GB |
dc.description.sponsorship | Medical Research Council (MRC) | en_GB |
dc.description.sponsorship | Canada Research Chair in Pediatric Oncology Supportive Care | en_GB |
dc.identifier.citation | Published online 27 My 2020 | en_GB |
dc.identifier.doi | 10.1200/JCO.20.00158 | |
dc.identifier.grantnumber | 097377 | en_GB |
dc.identifier.grantnumber | MR/N006364/2 | en_GB |
dc.identifier.uri | http://hdl.handle.net/10871/122514 | |
dc.language.iso | en | en_GB |
dc.publisher | American Society of Clinical Oncology | en_GB |
dc.relation.url | https://www.ncbi.nlm.nih.gov/pubmed/32459599 | en_GB |
dc.rights | © 2020 by American Society of Clinical Oncology. Open access under a Creative Commons Attribution Non-Commercial No Derivatives 4.0 License: https://creativecommons.org/licenses/by-nc-nd/4.0/ | en_GB |
dc.title | Clinical Practice Guideline for Systemic Antifungal Prophylaxis in Pediatric Patients With Cancer and Hematopoietic Stem-Cell Transplantation Recipients | en_GB |
dc.type | Article | en_GB |
dc.date.available | 2020-08-18T10:12:18Z | |
exeter.place-of-publication | United States | en_GB |
dc.description | This is the final version. Available on open access from the American Society of Clinical Oncology via the DOI in this record | en_GB |
dc.identifier.eissn | 1527-7755 | |
dc.identifier.journal | Journal of Clinical Oncology | en_GB |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | en_GB |
dcterms.dateAccepted | 2020-04-01 | |
rioxxterms.version | VoR | en_GB |
rioxxterms.licenseref.startdate | 2020-05-27 | |
rioxxterms.type | Journal Article/Review | en_GB |
refterms.dateFCD | 2020-08-18T10:09:04Z | |
refterms.versionFCD | VoR | |
refterms.dateFOA | 2020-08-18T10:12:22Z | |
refterms.panel | A | en_GB |
refterms.depositException | publishedGoldOA |
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Except where otherwise noted, this item's licence is described as © 2020 by American Society of Clinical Oncology. Open access under a Creative Commons Attribution Non-Commercial No Derivatives 4.0 License: https://creativecommons.org/licenses/by-nc-nd/4.0/