Recurrent delirium over 12 months predicts dementia: results of the Delirium and Cognitive Impact in Dementia (DECIDE) study
dc.contributor.author | Richardson, SJ | |
dc.contributor.author | Davis, DHJ | |
dc.contributor.author | Stephan, BCM | |
dc.contributor.author | Robinson, L | |
dc.contributor.author | Brayne, C | |
dc.contributor.author | Barnes, LE | |
dc.contributor.author | Taylor, J-P | |
dc.contributor.author | Parker, SG | |
dc.contributor.author | Allan, LM | |
dc.date.accessioned | 2020-10-05T15:04:56Z | |
dc.date.issued | 2020-12-16 | |
dc.description.abstract | Background: Delirium is common, distressing and associated with poor outcomes. Previous studies investigating the impact of delirium on cognitive outcomes have been limited by incomplete ascertainment of baseline cognition or lack of prospective delirium assessments. This study quantified the association between delirium and cognitive function over time by prospectively ascertaining delirium in a cohort aged ≥65 years in whom baseline cognition had previously been established. Methods: For 12 months, we assessed participants from the Cognitive Function and Ageing Study II-Newcastle for delirium daily during hospital admissions. At one-year, we assessed cognitive decline and dementia in those with and without delirium. We evaluated the effect of delirium (including its duration and number of episodes) on cognitive function over time, independently of baseline cognition and illness severity. Results: 82 of 205 participants recruited developed delirium in hospital (40%). One-year outcome data were available for 173 participants: 18 had a new dementia diagnosis, 38 had died. Delirium was associated with cognitive decline (-1·8 MMSE points [95% CI -3·5 - -0·2]) and an increased risk of new dementia diagnosis at follow up (OR 8·8 [95% CI 1·9 – 41·4]). More than one episode and more days with delirium (>5 days) were associated with worse cognitive outcomes. Conclusions: Delirium increases risk of future cognitive decline and dementia, independent of illness severity and baseline cognition, with more episodes associated with worse cognitive outcomes. Given that delirium has been shown to be preventable in some cases, we propose that delirium is a potentially modifiable risk factor for dementia. | en_GB |
dc.identifier.citation | Published online 16 December 2020 | en_GB |
dc.identifier.doi | 10.1093/ageing/afaa244 | |
dc.identifier.uri | http://hdl.handle.net/10871/123100 | |
dc.language.iso | en | en_GB |
dc.publisher | Oxford University Press (OUP) / British Geriatrics Society | en_GB |
dc.rights | © The Author(s) 2020. Published by Oxford University Press on behalf of the British Geriatrics Society. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. | |
dc.title | Recurrent delirium over 12 months predicts dementia: results of the Delirium and Cognitive Impact in Dementia (DECIDE) study | en_GB |
dc.type | Article | en_GB |
dc.date.available | 2020-10-05T15:04:56Z | |
dc.identifier.issn | 0002-0729 | |
dc.description | This is the final version. Available on open access from Oxford University Press via the DOI in this record | en_GB |
dc.identifier.journal | Age and Ageing | en_GB |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | en_GB |
dcterms.dateAccepted | 2020-09-29 | |
rioxxterms.version | VoR | en_GB |
rioxxterms.licenseref.startdate | 2020-09-29 | |
rioxxterms.type | Journal Article/Review | en_GB |
refterms.dateFCD | 2020-10-05T10:21:36Z | |
refterms.versionFCD | AM | |
refterms.dateFOA | 2021-01-15T14:05:34Z | |
refterms.panel | A | en_GB |
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Except where otherwise noted, this item's licence is described as © The Author(s) 2020. Published by Oxford University Press on behalf of the British Geriatrics Society.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.