Advances in the in vivo molecular imaging of invasive pulmonary aspergillosis
dc.contributor.author | Gunzer, M | |
dc.contributor.author | Thornton, CR | |
dc.contributor.author | Beziere, N | |
dc.date.accessioned | 2020-12-02T09:26:22Z | |
dc.date.issued | 2020-12-04 | |
dc.description.abstract | Invasive pulmonary aspergillosis (IPA) is a life-threatening infection of immunocompromised patients with Aspergillus fumigatus, a ubiquitous environmental mould. While there are numerous functioning antifungal therapies, their high cost, substantial side effects and fear of overt resistance development preclude permanent prophylactic medication of risk-patients. Hence, a fast and definitive diagnosis of IPA is desirable, to quickly identify those patients that really require aggressive antimycotic treatment and to follow the course of the therapeutic intervention. Yet, despite decades of research into this issue such a diagnostic procedure is still not available. Here we discuss the array of currently available methods for IPA detection and their limits. We then show that molecular imaging using positron-emission-tomography (PET) combined with morphological computed tomography or magnetic imaging is highly promising to become a future non-invasive approach for IPA diagnosis and therapy monitoring, albeit still requiring thorough validation and relying on further acceptance and dissemination of the approach. Thereby our approach using the A. fumigatus-specific humanized monoclonal antibody hJF5 labelled with 64Cu as PET-tracer has proven highly effective in pre-clinical models and hence bears high potential for human application. | en_GB |
dc.description.sponsorship | European Union FP7 | en_GB |
dc.identifier.citation | Vol. 6 (4), article 338 | en_GB |
dc.identifier.doi | 10.3390/jof6040338 | |
dc.identifier.grantnumber | 602820 | en_GB |
dc.identifier.uri | http://hdl.handle.net/10871/123861 | |
dc.language.iso | en | en_GB |
dc.publisher | MDPI | en_GB |
dc.rights | © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). | |
dc.subject | Aspergillus fumigatus | en_GB |
dc.subject | Invasive Pulmonary Aspergillosis | en_GB |
dc.subject | Aspergillosis | en_GB |
dc.subject | Imaging | en_GB |
dc.subject | Positron Emission Tomography | en_GB |
dc.subject | ImmunoPET | en_GB |
dc.subject | Siderophores | en_GB |
dc.subject | Imaging | en_GB |
dc.subject | Radiolabel | en_GB |
dc.title | Advances in the in vivo molecular imaging of invasive pulmonary aspergillosis | en_GB |
dc.type | Article | en_GB |
dc.date.available | 2020-12-02T09:26:22Z | |
dc.identifier.issn | 2309-608X | |
dc.description | This is the final version. Available on open access from MDPI via the DOI in this record | en_GB |
dc.identifier.journal | Journal of Fungi | en_GB |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | en_GB |
dcterms.dateAccepted | 2020-12-02 | |
rioxxterms.version | VoR | en_GB |
rioxxterms.licenseref.startdate | 2020-12-02 | |
rioxxterms.type | Journal Article/Review | en_GB |
refterms.dateFCD | 2020-12-02T08:48:43Z | |
refterms.versionFCD | AM | |
refterms.dateFOA | 2020-12-18T10:39:55Z | |
refterms.panel | A | en_GB |
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Except where otherwise noted, this item's licence is described as © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).