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dc.contributor.authorClarke, C
dc.contributor.authorHamilton, W
dc.contributor.authorPrice, S
dc.contributor.authorBailey, SER
dc.date.accessioned2021-01-07T10:53:15Z
dc.date.issued2020-11-26
dc.description.abstractBackground Thrombocytosis is an excess of platelets, which is diagnosed as a platelet count >400 × 109/l. An association of thrombocytosis with undiagnosed cancer has recently been established, but the association with non-malignant disease has not been studied in primary care. Aim To examine, in English primary care, the 1-year incidence of non-malignant diseases in patients with new thrombocytosis and the incidence of preexisting non-malignant diseases in patients who develop new thrombocytosis. Design and setting Prospective cohort study using English Clinical Practice Research Datalink data from 2000 to 2013. Method Newly incident and pre-existing rates of non-malignant diseases associated with thrombocytosis were compared between patients with thrombocytosis and age- and sex-matched patients with a normal platelet count. Fifteen candidate non-malignant diseases were identified from literature searches. Results In the thrombocytosis cohort of 39 850 patients, 4579 (11.5%) were newly diagnosed with any one of the candidate diseases, compared with 443 out of 9684 patients (4.6%) in the normal platelet count cohort (relative risk [RR] 2.5, 95% confidence intervals [CI] = 2.3 to 2.8); iron-deficiency anaemia was the most common new diagnosis (4.5% of patients with thrombocytosis, RR 4.9, 95% CI = 4.0 to 6.1). A total of 22 612 (57.0%) patients with thrombocytosis had a preexisting non-malignant diagnosis compared with 4846 patients (50%) in the normal platelet count cohort (odds ratio 1.3, 95% CI = 1.2 to 1.4). There was no statistically significant difference in cancer diagnoses between patients with and without preexisting disease in the thrombocytosis cohort. Conclusion Thrombocytosis is associated with several non-malignant diseases. Clinicians can use these findings as part of their holistic diagnostic approach to help guide further investigations and management of patients with thrombocytosis.en_GB
dc.description.sponsorshipNational Institute for Health Research (NIHR)en_GB
dc.description.sponsorshipUniversity of Exeteren_GB
dc.description.sponsorshipCancer Research UKen_GB
dc.identifier.citationVol. 70 (701), pp. e852-e857en_GB
dc.identifier.doi10.3399/BJGP20X713501
dc.identifier.grantnumberC8640/A23385en_GB
dc.identifier.grantnumber106/0001en_GB
dc.identifier.grantnumberPR-PRU-1217-21601en_GB
dc.identifier.urihttp://hdl.handle.net/10871/124322
dc.language.isoenen_GB
dc.publisherRoyal College of General Practitionersen_GB
dc.rights©The Authors. This article is Open Access: CC BY 4.0 licence (http://creativecommons.org/licences/by/4.0/).en_GB
dc.subjectcohort studiesen_GB
dc.subjectdiagnosisen_GB
dc.subjectincidenceen_GB
dc.subjectplatelet counten_GB
dc.subjectprevalenceen_GB
dc.subjectprimary careen_GB
dc.subjectthrombocytosisen_GB
dc.titleAssociation of non-malignant diseases with thrombocytosis: A prospective cohort study in general practiceen_GB
dc.typeArticleen_GB
dc.date.available2021-01-07T10:53:15Z
dc.identifier.issn0960-1643
dc.descriptionThis is the final version. Available on open access from the Royal College of General Practitioners via the DOI in this recorden_GB
dc.identifier.journalBritish Journal of General Practiceen_GB
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en_GB
dcterms.dateAccepted2020-05-14
rioxxterms.versionVoRen_GB
rioxxterms.licenseref.startdate2020-11-26
rioxxterms.typeJournal Article/Reviewen_GB
refterms.dateFCD2021-01-07T10:49:23Z
refterms.versionFCDVoR
refterms.dateFOA2021-01-07T10:53:34Z
refterms.panelAen_GB
refterms.depositExceptionpublishedGoldOA


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©The Authors.
This article is Open Access: CC BY 4.0 licence (http://creativecommons.org/licences/by/4.0/).
Except where otherwise noted, this item's licence is described as ©The Authors. This article is Open Access: CC BY 4.0 licence (http://creativecommons.org/licences/by/4.0/).