Association of non-malignant diseases with thrombocytosis: A prospective cohort study in general practice
dc.contributor.author | Clarke, C | |
dc.contributor.author | Hamilton, W | |
dc.contributor.author | Price, S | |
dc.contributor.author | Bailey, SER | |
dc.date.accessioned | 2021-01-07T10:53:15Z | |
dc.date.issued | 2020-11-26 | |
dc.description.abstract | Background Thrombocytosis is an excess of platelets, which is diagnosed as a platelet count >400 × 109/l. An association of thrombocytosis with undiagnosed cancer has recently been established, but the association with non-malignant disease has not been studied in primary care. Aim To examine, in English primary care, the 1-year incidence of non-malignant diseases in patients with new thrombocytosis and the incidence of preexisting non-malignant diseases in patients who develop new thrombocytosis. Design and setting Prospective cohort study using English Clinical Practice Research Datalink data from 2000 to 2013. Method Newly incident and pre-existing rates of non-malignant diseases associated with thrombocytosis were compared between patients with thrombocytosis and age- and sex-matched patients with a normal platelet count. Fifteen candidate non-malignant diseases were identified from literature searches. Results In the thrombocytosis cohort of 39 850 patients, 4579 (11.5%) were newly diagnosed with any one of the candidate diseases, compared with 443 out of 9684 patients (4.6%) in the normal platelet count cohort (relative risk [RR] 2.5, 95% confidence intervals [CI] = 2.3 to 2.8); iron-deficiency anaemia was the most common new diagnosis (4.5% of patients with thrombocytosis, RR 4.9, 95% CI = 4.0 to 6.1). A total of 22 612 (57.0%) patients with thrombocytosis had a preexisting non-malignant diagnosis compared with 4846 patients (50%) in the normal platelet count cohort (odds ratio 1.3, 95% CI = 1.2 to 1.4). There was no statistically significant difference in cancer diagnoses between patients with and without preexisting disease in the thrombocytosis cohort. Conclusion Thrombocytosis is associated with several non-malignant diseases. Clinicians can use these findings as part of their holistic diagnostic approach to help guide further investigations and management of patients with thrombocytosis. | en_GB |
dc.description.sponsorship | National Institute for Health Research (NIHR) | en_GB |
dc.description.sponsorship | University of Exeter | en_GB |
dc.description.sponsorship | Cancer Research UK | en_GB |
dc.identifier.citation | Vol. 70 (701), pp. e852-e857 | en_GB |
dc.identifier.doi | 10.3399/BJGP20X713501 | |
dc.identifier.grantnumber | C8640/A23385 | en_GB |
dc.identifier.grantnumber | 106/0001 | en_GB |
dc.identifier.grantnumber | PR-PRU-1217-21601 | en_GB |
dc.identifier.uri | http://hdl.handle.net/10871/124322 | |
dc.language.iso | en | en_GB |
dc.publisher | Royal College of General Practitioners | en_GB |
dc.rights | ©The Authors. This article is Open Access: CC BY 4.0 licence (http://creativecommons.org/licences/by/4.0/). | en_GB |
dc.subject | cohort studies | en_GB |
dc.subject | diagnosis | en_GB |
dc.subject | incidence | en_GB |
dc.subject | platelet count | en_GB |
dc.subject | prevalence | en_GB |
dc.subject | primary care | en_GB |
dc.subject | thrombocytosis | en_GB |
dc.title | Association of non-malignant diseases with thrombocytosis: A prospective cohort study in general practice | en_GB |
dc.type | Article | en_GB |
dc.date.available | 2021-01-07T10:53:15Z | |
dc.identifier.issn | 0960-1643 | |
dc.description | This is the final version. Available on open access from the Royal College of General Practitioners via the DOI in this record | en_GB |
dc.identifier.journal | British Journal of General Practice | en_GB |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | en_GB |
dcterms.dateAccepted | 2020-05-14 | |
rioxxterms.version | VoR | en_GB |
rioxxterms.licenseref.startdate | 2020-11-26 | |
rioxxterms.type | Journal Article/Review | en_GB |
refterms.dateFCD | 2021-01-07T10:49:23Z | |
refterms.versionFCD | VoR | |
refterms.dateFOA | 2021-01-07T10:53:34Z | |
refterms.panel | A | en_GB |
refterms.depositException | publishedGoldOA |
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This article is Open Access: CC BY 4.0 licence (http://creativecommons.org/licences/by/4.0/).