Feasibility of salivary cortisol collection in patients and companions attending dementia diagnostic meetings in memory clinics
dc.contributor.author | Pavlickova, H | |
dc.contributor.author | Russell, AE | |
dc.contributor.author | Lightman, S | |
dc.contributor.author | McCabe, R | |
dc.date.accessioned | 2021-01-25T11:15:32Z | |
dc.date.issued | 2021-01-21 | |
dc.description.abstract | Objectives Receiving a diagnosis of dementia is life-changing for the individual and their companion. The aim of the study was to explore the feasibility of collecting salivary cortisol from patients who are informed if they have dementia and their companions. Patients and companions collected nine saliva samples in three batches: 1–2 weeks before, immediately before, and immediately after the diagnostic meeting. Each batch consisted of three samples taken in the evening, after awaking and 30 mins post-waking. Results 22.7% (N = 10) of 44 invited patients and nine companions agreed, with 18.2% patients (N = 8) and 15.9% companions (N = 7) providing samples. Participants found that saliva collection was demanding and disrupted routines. On a purely descriptive level, some indications of an increased cortisol stress response in patients diagnosed with dementia were found in this very small sample. Researchers should expect low recruitment rates in this elderly population. Simpler collection procedures, e.g. pre-labelled packages with date/time, possible omission of morning samples and objective rather than self-report assessment of waking and saliva collection times—using actigraphy wrist-watches bleeps to prompt people at the timepoints and electronic track caps—might improve adherence and improve the accuracy of timepoints when swabs were actually collected. | en_GB |
dc.description.sponsorship | National Institute for Health Research (NIHR) | en_GB |
dc.identifier.citation | Vol. 14, article 30 | en_GB |
dc.identifier.doi | 10.1186/s13104-021-05446-6 | |
dc.identifier.grantnumber | PB-PG-1111-26063 | en_GB |
dc.identifier.uri | http://hdl.handle.net/10871/124493 | |
dc.language.iso | en | en_GB |
dc.publisher | BMC | en_GB |
dc.rights | © The Author(s) 2021. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/ zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. | en_GB |
dc.subject | Cortisol | en_GB |
dc.subject | Dementia | en_GB |
dc.subject | Diagnostic meeting | en_GB |
dc.subject | Memory clinic | en_GB |
dc.title | Feasibility of salivary cortisol collection in patients and companions attending dementia diagnostic meetings in memory clinics | en_GB |
dc.type | Article | en_GB |
dc.date.available | 2021-01-25T11:15:32Z | |
exeter.article-number | 30 | en_GB |
dc.description | This is the final version. Available on open access from BMC via the DOI in this record | en_GB |
dc.description | Availability of data and materials: The datasets generated and/or analysed during the current study are available from the corresponding author on reasonable request | en_GB |
dc.identifier.eissn | 1756-0500 | |
dc.identifier.journal | BMC Research Notes | en_GB |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | en_GB |
dcterms.dateAccepted | 2021-01-08 | |
rioxxterms.version | VoR | en_GB |
rioxxterms.licenseref.startdate | 2021-01-21 | |
rioxxterms.type | Journal Article/Review | en_GB |
refterms.dateFCD | 2021-01-25T11:14:07Z | |
refterms.versionFCD | VoR | |
refterms.dateFOA | 2021-01-25T11:15:37Z | |
refterms.panel | A | en_GB |
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is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the
permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/
zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.