The acute and postprandial effects of sugar moiety on vascular and metabolic health outcomes in adolescents
Koep, JL; Barker, AR; Banks, R; et al.Banger, RR; Lester, A; Sansum, KM; Weston, ME; Bond, B
Date: 17 February 2021
Journal
Applied Physiology, Nutrition and Metabolism
Publisher
Canadian Science Publishing / Canadian Society for Exercise Physiology / Canadian Nutrition Society
Publisher DOI
Abstract
This study explored the cardiometabolic responses to sugar moieties acutely, and following a
subsequent mixed meal tolerance test (MMTT). Twenty-one healthy adolescents (N=10
female, 14.3±0.4 years) completed three experimental and one control condition, in a
counterbalanced order. These consisted of different drinks to compare the ...
This study explored the cardiometabolic responses to sugar moieties acutely, and following a
subsequent mixed meal tolerance test (MMTT). Twenty-one healthy adolescents (N=10
female, 14.3±0.4 years) completed three experimental and one control condition, in a
counterbalanced order. These consisted of different drinks to compare the effect of 300 mL of
water (control), or 300 mL of water mixed with 60 g of glucose, fructose or sucrose, on vascular
function (flow-mediated dilation; FMD, microvascular reactivity (total hyperaemic response;
TRH); and cerebrovascular reactivity; CVR), and blood samples for [uric acid], [glucose],
[triglycerides] and [lactate]. FMD increased 1 hour after glucose and sucrose (P<0.001,
ES≥0.92) but was unchanged following fructose and water (P>0.19, ES>0.09). CVR and TRH
were unchanged 1 hour following all conditions (P>0.57, ES>0.02). Following the MMTT, FMD
was impaired in all conditions (P<0.001, ES>0.40) with no differences between conditions
(P>0.13, ES<0.39). Microvascular TRH was increased in all conditions (P=0.001, ES=0.88),
and CVR was preserved in all conditions post MMTT (P=0.87, ES=0.02). Blood [uric acid] was
elevated following fructose consumption and the MMTT (P<0.01, ES>0.40). Consumption of a
sugar sweetened beverage did not result in vascular dysfunction in healthy adolescents,
however the vascular and metabolic responses were dependent on sugar moiety.
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