The acute and postprandial effects of sugar moiety on vascular and metabolic health outcomes in adolescents
dc.contributor.author | Koep, JL | |
dc.contributor.author | Barker, AR | |
dc.contributor.author | Banks, R | |
dc.contributor.author | Banger, RR | |
dc.contributor.author | Lester, A | |
dc.contributor.author | Sansum, KM | |
dc.contributor.author | Weston, ME | |
dc.contributor.author | Bond, B | |
dc.date.accessioned | 2021-02-03T12:24:41Z | |
dc.date.issued | 2021-02-17 | |
dc.description.abstract | This study explored the cardiometabolic responses to sugar moieties acutely, and following a subsequent mixed meal tolerance test (MMTT). Twenty-one healthy adolescents (N=10 female, 14.3±0.4 years) completed three experimental and one control condition, in a counterbalanced order. These consisted of different drinks to compare the effect of 300 mL of water (control), or 300 mL of water mixed with 60 g of glucose, fructose or sucrose, on vascular function (flow-mediated dilation; FMD, microvascular reactivity (total hyperaemic response; TRH); and cerebrovascular reactivity; CVR), and blood samples for [uric acid], [glucose], [triglycerides] and [lactate]. FMD increased 1 hour after glucose and sucrose (P<0.001, ES≥0.92) but was unchanged following fructose and water (P>0.19, ES>0.09). CVR and TRH were unchanged 1 hour following all conditions (P>0.57, ES>0.02). Following the MMTT, FMD was impaired in all conditions (P<0.001, ES>0.40) with no differences between conditions (P>0.13, ES<0.39). Microvascular TRH was increased in all conditions (P=0.001, ES=0.88), and CVR was preserved in all conditions post MMTT (P=0.87, ES=0.02). Blood [uric acid] was elevated following fructose consumption and the MMTT (P<0.01, ES>0.40). Consumption of a sugar sweetened beverage did not result in vascular dysfunction in healthy adolescents, however the vascular and metabolic responses were dependent on sugar moiety. | en_GB |
dc.identifier.citation | Published online 17 February 2021 | en_GB |
dc.identifier.doi | 10.1139/apnm-2020-0853 | |
dc.identifier.uri | http://hdl.handle.net/10871/124601 | |
dc.language.iso | en | en_GB |
dc.publisher | Canadian Science Publishing / Canadian Society for Exercise Physiology / Canadian Nutrition Society | en_GB |
dc.rights | © 2021 Canadian Science Publishing | |
dc.subject | sugar sweetened beverage | en_GB |
dc.subject | fructose | en_GB |
dc.subject | hyperglycaemia | en_GB |
dc.subject | cardiovascular disease | en_GB |
dc.subject | sucrose | en_GB |
dc.subject | endothelial function | en_GB |
dc.subject | glucose | en_GB |
dc.subject | adolescents | en_GB |
dc.subject | FMD | en_GB |
dc.subject | vascular function | en_GB |
dc.title | The acute and postprandial effects of sugar moiety on vascular and metabolic health outcomes in adolescents | en_GB |
dc.type | Article | en_GB |
dc.date.available | 2021-02-03T12:24:41Z | |
dc.description | This is the author accepted manuscript. The final version is available from Canadian Science Publishing via the DOI in this record | en_GB |
dc.identifier.eissn | 1715-5320 | |
dc.identifier.journal | Applied Physiology, Nutrition and Metabolism | en_GB |
dc.rights.uri | http://www.rioxx.net/licenses/all-rights-reserved | en_GB |
dcterms.dateAccepted | 2021-01-28 | |
rioxxterms.version | AM | en_GB |
rioxxterms.licenseref.startdate | 2021-01-28 | |
rioxxterms.type | Journal Article/Review | en_GB |
refterms.dateFCD | 2021-02-03T12:05:55Z | |
refterms.versionFCD | AM | |
refterms.dateFOA | 2021-02-23T13:59:13Z | |
refterms.panel | C | en_GB |