An exploration of the genetic epidemiology of non-suicidal self-harm and suicide attempt
dc.contributor.author | Russell, AE | |
dc.contributor.author | Hemani, G | |
dc.contributor.author | Jones, HJ | |
dc.contributor.author | Ford, T | |
dc.contributor.author | Gunnell, D | |
dc.contributor.author | Heron, J | |
dc.contributor.author | Moran, P | |
dc.contributor.author | Joinson, C | |
dc.contributor.author | Relton, C | |
dc.contributor.author | Suderman, M | |
dc.contributor.author | Watkins, S | |
dc.contributor.author | Mars, B | |
dc.date.accessioned | 2021-04-20T06:30:30Z | |
dc.date.issued | 2021-04-23 | |
dc.description.abstract | Background: Empirical evidence supporting the distinction between suicide attempt (SA) and non-suicidal selfharm (NSSH) is lacking. Although NSSH is a risk factor for SA, we do not currently know whether these behaviours lie on a continuum of severity, or whether they are discrete outcomes with different aetiologies. We conducted this exploratory genetic epidemiology study to investigate this issue further. Methods: We explored the extent of genetic overlap between NSSH and SA in a large, richly-phenotyped cohort (the Avon Longitudinal Study of Parents and Children; N = 4959), utilising individual-level genetic and phenotypic data to conduct analyses of genome-wide complex traits and polygenic risk scores (PRS). Results: The single nucleotide polymorphism heritability of NSSH was estimated to be 13% (SE 0.07) and that of SA to be 0% (SE 0.07). Of the traits investigated, NSSH was most strongly correlated with higher IQ (rG = 0.31, SE = 0.22), there was little evidence of high genetic correlation between NSSH and SA (rG = − 0.1, SE = 0.54), likely due to the low heritability estimate for SA. The PRS for depression differentiated between those with NSSH and SA in multinomial regression. The optimal PRS prediction model for SA (Nagelkerke R2 0.022, p < 0.001) included ADHD, depression, income, anorexia and neuroticism and explained more variance than the optimal prediction model for NSSH (Nagelkerke R2 0.010, p < 0.001) which included ADHD, alcohol consumption, autism spectrum conditions, depression, IQ, neuroticism and suicide attempt. Conclusions: Our findings suggest that SA does not have a large genetic component, and that although NSSH and SA are not discrete outcomes there appears to be little genetic overlap between the two. The relatively small sample size and resulting low heritability estimate for SA was a limitation of the study. Combined with low heritability estimates, this implies that family or population structures in SA GWASs may contribute to signals detected. | en_GB |
dc.description.sponsorship | Medical Research Council (MRC) | en_GB |
dc.description.sponsorship | Wellcome Trust | en_GB |
dc.identifier.citation | Vol. 21, article 207 | en_GB |
dc.identifier.doi | 10.1186/s12888-021-03216-z | |
dc.identifier.grantnumber | MR/R004889/1 | en_GB |
dc.identifier.grantnumber | 217065/Z/19/Z | en_GB |
dc.identifier.uri | http://hdl.handle.net/10871/125400 | |
dc.language.iso | en | en_GB |
dc.publisher | BMC | en_GB |
dc.rights | © The Author(s). 2021. Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data | |
dc.subject | suicide | en_GB |
dc.subject | self-harm | en_GB |
dc.subject | non-suicidal self-injury | en_GB |
dc.subject | genetic epidemiology | en_GB |
dc.subject | polygenic risk scores | en_GB |
dc.title | An exploration of the genetic epidemiology of non-suicidal self-harm and suicide attempt | en_GB |
dc.type | Article | en_GB |
dc.date.available | 2021-04-20T06:30:30Z | |
dc.identifier.issn | 1471-244X | |
dc.description | This is the final version. Available on open access from BMC via the DOI in this record | en_GB |
dc.identifier.journal | BMC Psychiatry | en_GB |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | en_GB |
dcterms.dateAccepted | 2021-04-14 | |
rioxxterms.version | VoR | en_GB |
rioxxterms.licenseref.startdate | 2021-04-14 | |
rioxxterms.type | Journal Article/Review | en_GB |
refterms.dateFCD | 2021-04-19T13:48:57Z | |
refterms.versionFCD | AM | |
refterms.dateFOA | 2021-04-20T06:30:34Z | |
refterms.panel | A | en_GB |
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The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the
data made available in this article, unless otherwise stated in a credit line to the data