All thresholds of maternal hyperglycaemia from the WHO 2013 criteria for gestational diabetes identify women with a higher genetic risk for type 2 diabetes
dc.contributor.author | Hughes, AE | |
dc.contributor.author | Hayes, MG | |
dc.contributor.author | Egan, AM | |
dc.contributor.author | Patel, KA | |
dc.contributor.author | Scholtens, DM | |
dc.contributor.author | Lowe, LP | |
dc.contributor.author | Lowe, WL | |
dc.contributor.author | Dunne, FP | |
dc.contributor.author | Hattersley, AT | |
dc.contributor.author | Freathy, RM | |
dc.date.accessioned | 2021-04-21T12:07:38Z | |
dc.date.issued | 2021-03-23 | |
dc.description.abstract | Background: Using genetic scores for fasting plasma glucose (FPG GS) and type 2 diabetes (T2D GS), we investigated whether the fasting, 1-hour and 2-hour glucose thresholds from the WHO 2013 criteria for gestational diabetes (GDM) have different implications for genetic susceptibility to raised fasting glucose and type 2 diabetes in women from the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) and Atlantic Diabetes in Pregnancy (DIP) studies. Methods: Cases were divided into three subgroups: (i) FPG ≥5.1 mmol/L only, n=222; (ii) 1-hour glucose post 75 g oral glucose load ≥10 mmol/L only, n=154 (iii) 2-hour glucose ≥8.5 mmol/L only, n=73; and (iv) both FPG ≥5.1 mmol/L and either of a 1-hour glucose ≥10 mmol/L or 2-hour glucose ≥8.5 mmol/L, n=172. We compared the FPG and T2D GS of these groups with controls (n=3,091) in HAPO and DIP separately. Results: In HAPO and DIP, the mean FPG GS in women with a FPG ≥5.1 mmol/L, either on its own or with 1-hour glucose ≥10 mmol/L or 2-hour glucose ≥8.5 mmol/L, was higher than controls (all P <0.01). Mean T2D GS in women with a raised FPG alone or with either a raised 1-hour or 2-hour glucose was higher than controls (all P <0.05). GDM defined by 1-hour or 2-hour hyperglycaemia only was also associated with a higher T2D GS than controls (all P <0.05). Conclusions: The different diagnostic categories that are part of the WHO 2013 criteria for GDM identify women with a genetic predisposition to type 2 diabetes as well as a risk for adverse pregnancy outcomes. | en_GB |
dc.description.sponsorship | Wellcome Trust | en_GB |
dc.description.sponsorship | National Institute for Health Research | en_GB |
dc.description.sponsorship | Eunice Kennedy Shriver National Institute of Child Health and Human Development | en_GB |
dc.description.sponsorship | National Human Genome Research Institute | en_GB |
dc.description.sponsorship | National Institute of Diabetes and Digestive and Kidney Diseases | en_GB |
dc.description.sponsorship | American Diabetes Association | en_GB |
dc.description.sponsorship | Ireland Health Research Board | en_GB |
dc.identifier.citation | Vol. 5, article 175 | en_GB |
dc.identifier.doi | 10.12688/wellcomeopenres.16097.3 | |
dc.identifier.grantnumber | 110082 | en_GB |
dc.identifier.grantnumber | HD-34242 and HD32423 | en_GB |
dc.identifier.grantnumber | HG-004415 | en_GB |
dc.identifier.grantnumber | DK-DK097534 | en_GB |
dc.identifier.uri | http://hdl.handle.net/10871/125409 | |
dc.language.iso | en | en_GB |
dc.publisher | F1000Research/Wellcome Trust | en_GB |
dc.rights | Copyright: © 2021 Hughes AE et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited | en_GB |
dc.subject | Gestational diabetes | en_GB |
dc.subject | genetic scores | en_GB |
dc.subject | fasting plasma glucose | en_GB |
dc.subject | type 2 diabetes | en_GB |
dc.title | All thresholds of maternal hyperglycaemia from the WHO 2013 criteria for gestational diabetes identify women with a higher genetic risk for type 2 diabetes | en_GB |
dc.type | Article | en_GB |
dc.date.available | 2021-04-21T12:07:38Z | |
dc.description | This is the final version. Available from F1000Research via the DOI in this record. | en_GB |
dc.description | Data availability Underlying data Data is not freely available due to it consisting of potentially identifiable information, and as such is held securely to protect the interests of research participants in line with the guidance from the relevant ethics committees. However, the ethics committees will allow data analysed and generated in this study to be available to researchers through open collaboration. For access to the data used in this study please contact Dr Rachel Freathy (r.freathy@exeter.ac.uk) and Professor William Lowe Jr (wlowe@northwestern.edu) in relation to HAPO and Dr Rachel Freathy and Professor Fidelma Dunne (fidelma.dunne@nuigalway.ie) in relation to Atlantic DIP. Requests will be reviewed as soon as possible on receipt and will be facilitated with an agreement to ensure that data is transferred and held securely and results of new analyses shared with the relevant study investigators. The websites describing the studies and other data available are https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000096.v4.p1 for HAPO and http://atlanticdipireland.com/for Atlantic DIP. Extended data Figshare: Extended data Wellcome Open Research 16097.pdf. https://doi.org/10.6084/m9.figshare.14180033 The file contains an extended data table with sensitivity analyses adjusting the genetic scores for maternal pre-pregnancy BMI and age and a figure with a directed acyclic graph (DAG) showing how the relationships between the genetic scores and GDM diagnostic category are not driven by maternal pre-pregnancy BMI or age. | en_GB |
dc.identifier.eissn | 2398-502X | |
dc.identifier.journal | Wellcome Open Research | en_GB |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | en_GB |
dcterms.dateAccepted | 2021-02-08 | |
rioxxterms.version | VoR | en_GB |
rioxxterms.licenseref.startdate | 2021-03-23 | |
rioxxterms.type | Journal Article/Review | en_GB |
refterms.dateFCD | 2021-04-21T11:57:10Z | |
refterms.versionFCD | VoR | |
refterms.dateFOA | 2021-04-21T12:07:56Z | |
refterms.panel | A | en_GB |
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