The genetic architecture of a host shift: An adaptive walk protected an aphid and its endosymbiont from plant chemical defenses
dc.contributor.author | Singh, KS | |
dc.contributor.author | Troczka, BJ | |
dc.contributor.author | Duarte, A | |
dc.contributor.author | Balabanidou, V | |
dc.contributor.author | Trissi, N | |
dc.contributor.author | Carabajal Paladino, LZ | |
dc.contributor.author | Nguyen, P | |
dc.contributor.author | Zimmer, CT | |
dc.contributor.author | Papapostolou, KM | |
dc.contributor.author | Randall, E | |
dc.contributor.author | Lueke, B | |
dc.contributor.author | Marec, F | |
dc.contributor.author | Mazzoni, E | |
dc.contributor.author | Williamson, MS | |
dc.contributor.author | Hayward, A | |
dc.contributor.author | Nauen, R | |
dc.contributor.author | Vontas, J | |
dc.contributor.author | Bass, C | |
dc.date.accessioned | 2021-04-22T09:36:42Z | |
dc.date.issued | 2020-05-06 | |
dc.description.abstract | Host shifts can lead to ecological speciation and the emergence of new pests and pathogens. However, the mutational events that facilitate the exploitation of novel hosts are poorly understood. Here, we characterize an adaptive walk underpinning the host shift of the aphid Myzus persicae to tobacco, including evolution of mechanisms that overcame tobacco chemical defenses. A series of mutational events added as many as 1.5 million nucleotides to the genome of the tobacco-adapted subspecies, M. p. nicotianae, and yielded profound increases in expression of an enzyme that efficiently detoxifies nicotine, both in aphid gut tissue and in the bacteriocytes housing the obligate aphid symbiont Buchnera aphidicola. This dual evolutionary solution overcame the challenge of preserving fitness of a mutualistic symbiosis during adaptation to a toxic novel host. Our results reveal the intricate processes by which genetic novelty can arise and drive the evolution of key innovations required for ecological adaptation. | en_GB |
dc.description.sponsorship | European Union Horizon 2020 | en_GB |
dc.description.sponsorship | Czech Science Foundation | en_GB |
dc.description.sponsorship | Czech Science Foundation | en_GB |
dc.description.sponsorship | European Social Fund and the state budget of the Czech Republic | en_GB |
dc.description.sponsorship | Biotechnology and Biological Sciences Research Council (BBSRC) | en_GB |
dc.identifier.citation | Vol. 6 (19), article eaba1070 | en_GB |
dc.identifier.doi | 10.1126/sciadv.aba1070 | |
dc.identifier.grantnumber | 646625 | en_GB |
dc.identifier.grantnumber | 17-17211S | en_GB |
dc.identifier.grantnumber | 17-13713S | en_GB |
dc.identifier.grantnumber | CZ.1.07/2.3.00/30.0032 | en_GB |
dc.identifier.grantnumber | BB/N020146/1 | en_GB |
dc.identifier.uri | http://hdl.handle.net/10871/125435 | |
dc.language.iso | en | en_GB |
dc.publisher | American Association for the Advancement of Science | en_GB |
dc.rights | © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY). This is an open-access article distributed under the terms of the Creative Commons Attribution license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | en_GB |
dc.title | The genetic architecture of a host shift: An adaptive walk protected an aphid and its endosymbiont from plant chemical defenses | en_GB |
dc.type | Article | en_GB |
dc.date.available | 2021-04-22T09:36:42Z | |
dc.description | This is the final version. Available from American Association for the Advancement of Science via the DOI in this record. | en_GB |
dc.description | The RNA and DNA sequence data generated in this study have been deposited with NCBI under accession number PRJNA574571. The sequence of RPS11/ADAMTS9 has been deposited under NCBI accession number MF1555663, and the accession numbers of other genes characterized in this study can be found in data file S1. All other data needed to evaluate the conclusions in the paper are present in the paper and/or the Supplementary Materials. Additional data related to this paper may be requested from the authors. | en_GB |
dc.identifier.journal | Science Advances | en_GB |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | en_GB |
dcterms.dateAccepted | 2020-02-18 | |
rioxxterms.version | VoR | en_GB |
rioxxterms.licenseref.startdate | 2020-02-18 | |
rioxxterms.type | Journal Article/Review | en_GB |
refterms.dateFCD | 2021-04-22T09:27:55Z | |
refterms.versionFCD | VoR | |
refterms.dateFOA | 2021-04-22T09:37:07Z | |
refterms.panel | A | en_GB |
refterms.depositException | publishedGoldOA |
Files in this item
This item appears in the following Collection(s)
Except where otherwise noted, this item's licence is described as © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY). This is an open-access article distributed under the terms of the Creative Commons Attribution license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.