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dc.contributor.authorSingh, KS
dc.contributor.authorTroczka, BJ
dc.contributor.authorDuarte, A
dc.contributor.authorBalabanidou, V
dc.contributor.authorTrissi, N
dc.contributor.authorCarabajal Paladino, LZ
dc.contributor.authorNguyen, P
dc.contributor.authorZimmer, CT
dc.contributor.authorPapapostolou, KM
dc.contributor.authorRandall, E
dc.contributor.authorLueke, B
dc.contributor.authorMarec, F
dc.contributor.authorMazzoni, E
dc.contributor.authorWilliamson, MS
dc.contributor.authorHayward, A
dc.contributor.authorNauen, R
dc.contributor.authorVontas, J
dc.contributor.authorBass, C
dc.date.accessioned2021-04-22T09:36:42Z
dc.date.issued2020-05-06
dc.description.abstractHost shifts can lead to ecological speciation and the emergence of new pests and pathogens. However, the mutational events that facilitate the exploitation of novel hosts are poorly understood. Here, we characterize an adaptive walk underpinning the host shift of the aphid Myzus persicae to tobacco, including evolution of mechanisms that overcame tobacco chemical defenses. A series of mutational events added as many as 1.5 million nucleotides to the genome of the tobacco-adapted subspecies, M. p. nicotianae, and yielded profound increases in expression of an enzyme that efficiently detoxifies nicotine, both in aphid gut tissue and in the bacteriocytes housing the obligate aphid symbiont Buchnera aphidicola. This dual evolutionary solution overcame the challenge of preserving fitness of a mutualistic symbiosis during adaptation to a toxic novel host. Our results reveal the intricate processes by which genetic novelty can arise and drive the evolution of key innovations required for ecological adaptation.en_GB
dc.description.sponsorshipEuropean Union Horizon 2020en_GB
dc.description.sponsorshipCzech Science Foundationen_GB
dc.description.sponsorshipCzech Science Foundationen_GB
dc.description.sponsorshipEuropean Social Fund and the state budget of the Czech Republicen_GB
dc.description.sponsorshipBiotechnology and Biological Sciences Research Council (BBSRC)en_GB
dc.identifier.citationVol. 6 (19), article eaba1070en_GB
dc.identifier.doi10.1126/sciadv.aba1070
dc.identifier.grantnumber646625en_GB
dc.identifier.grantnumber17-17211Sen_GB
dc.identifier.grantnumber17-13713Sen_GB
dc.identifier.grantnumberCZ.1.07/2.3.00/30.0032en_GB
dc.identifier.grantnumberBB/N020146/1en_GB
dc.identifier.urihttp://hdl.handle.net/10871/125435
dc.language.isoenen_GB
dc.publisherAmerican Association for the Advancement of Scienceen_GB
dc.rights© 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY). This is an open-access article distributed under the terms of the Creative Commons Attribution license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en_GB
dc.titleThe genetic architecture of a host shift: An adaptive walk protected an aphid and its endosymbiont from plant chemical defensesen_GB
dc.typeArticleen_GB
dc.date.available2021-04-22T09:36:42Z
dc.descriptionThis is the final version. Available from American Association for the Advancement of Science via the DOI in this record. en_GB
dc.descriptionThe RNA and DNA sequence data generated in this study have been deposited with NCBI under accession number PRJNA574571. The sequence of RPS11/ADAMTS9 has been deposited under NCBI accession number MF1555663, and the accession numbers of other genes characterized in this study can be found in data file S1. All other data needed to evaluate the conclusions in the paper are present in the paper and/or the Supplementary Materials. Additional data related to this paper may be requested from the authors.en_GB
dc.identifier.journalScience Advancesen_GB
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_GB
dcterms.dateAccepted2020-02-18
rioxxterms.versionVoRen_GB
rioxxterms.licenseref.startdate2020-02-18
rioxxterms.typeJournal Article/Reviewen_GB
refterms.dateFCD2021-04-22T09:27:55Z
refterms.versionFCDVoR
refterms.dateFOA2021-04-22T09:37:07Z
refterms.panelAen_GB
refterms.depositExceptionpublishedGoldOA


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© 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY). This is an open-access article distributed under the terms of the Creative Commons Attribution license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Except where otherwise noted, this item's licence is described as © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY). This is an open-access article distributed under the terms of the Creative Commons Attribution license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.