An appraisal of trials investigating the effects on macular pigment optical density of lutein and zeaxanthin dietary interventions: a narrative review
Fitzpatrick, N; Chachay, V; Bowtell, J; et al.Jackman, S; Capra, S; Shore, A; Briskey, D
Date: 2 August 2021
Journal
Nutrition Reviews
Publisher
Oxford University Press / International Life Sciences Institute
Publisher DOI
Abstract
Lutein and zeaxanthin (L/Z), xanthophylls obtained from the diet, are deposited in
the macula of the eye. The macular concentration of L/Z is quantifiable as macular pigment
optical density (MPOD). The aim of this review was to critically appraise the effect on MPOD
of increasing L/Z intake by dietary intervention in adults. ...
Lutein and zeaxanthin (L/Z), xanthophylls obtained from the diet, are deposited in
the macula of the eye. The macular concentration of L/Z is quantifiable as macular pigment
optical density (MPOD). The aim of this review was to critically appraise the effect on MPOD
of increasing L/Z intake by dietary intervention in adults. Pubmed, Cochrane Library, Web of
Science, and Cinahl were searched up to April 2020. Ten studies investigating populations with
and without age-related macular degeneration were included. MPOD increased significantly in
two of the eight controlled studies. Studies varied largely in the prescribed dietary L/Z dosage,
duration, and participant characteristics. No relationships between types of dietary L/Z
interventions and MPOD response could be determined. Limited monitoring of habitual dietary
L/Z intake was identified as a major limitation of all ten studies. Habitual dietary L/Z intake
should be closely monitored in future studies to account for their effects on MPOD response
to dietary L/Z interventions.
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