Epitranscriptomic regulation of insecticide resistance
dc.contributor.author | Yang, X | |
dc.contributor.author | Wei, X | |
dc.contributor.author | Yang, J | |
dc.contributor.author | Du, T | |
dc.contributor.author | Yin, C | |
dc.contributor.author | Fu, B | |
dc.contributor.author | Huang, M | |
dc.contributor.author | Liang, J | |
dc.contributor.author | Gong, P | |
dc.contributor.author | Liu, S | |
dc.contributor.author | Xie, W | |
dc.contributor.author | Guo, Z | |
dc.contributor.author | Wang, S | |
dc.contributor.author | Wu, Q | |
dc.contributor.author | Nauen, R | |
dc.contributor.author | Zhou, X | |
dc.contributor.author | Bass, C | |
dc.contributor.author | Zhang, Y | |
dc.date.accessioned | 2021-05-17T07:54:01Z | |
dc.date.issued | 2021-05-05 | |
dc.description.abstract | N6-methyladenosine (m6A) is the most prevalent messenger RNA modification in eukaryotes and an important posttranscriptional regulator of gene expression. However, the biological roles of m6A in most insects remain largely unknown. Here, we show that m6A regulates a cytochrome P450 gene (CYP4C64) in the global whitefly pest, Bemisia tabaci, leading to insecticide resistance. Investigation of the regulation of CYP4C64, which confers resistance to the insecticide thiamethoxam, revealed a mutation in the 5′ untranslated region of this gene in resistant B. tabaci strains that introduces a predicted m6A site. We provide several lines of evidence that mRNA methylation of the adenine at this position, in combination with modified expression of m6A writers, acts to increase expression of CYP4C64 and resistance. Collectively, these results provide an example of the epitranscriptomic regulation of the xenobiotic response in insects and implicate the m6A regulatory axis in the development of insecticide resistance. | en_GB |
dc.description.sponsorship | National Key R&D Program of China | en_GB |
dc.description.sponsorship | China Agriculture Research System | en_GB |
dc.description.sponsorship | Beijing Key Laboratory for Pest Control and Sustainable Cultivation of Vegetables | en_GB |
dc.description.sponsorship | Science and Technology Innovation Program of the Chinese Academy of Agricultural Sciences | en_GB |
dc.description.sponsorship | European Union Horizon 2020 | en_GB |
dc.identifier.citation | Vol. 7 (19), article eabe5903 | en_GB |
dc.identifier.doi | 10.1126/sciadv.abe5903 | |
dc.identifier.grantnumber | 2019YFD1002100 | en_GB |
dc.identifier.grantnumber | 2016YFD0200500 | en_GB |
dc.identifier.grantnumber | CARS-24-C-02 | en_GB |
dc.identifier.grantnumber | CAAS-ASTIP-IVFCAAS | en_GB |
dc.identifier.grantnumber | 646625 | en_GB |
dc.identifier.uri | http://hdl.handle.net/10871/125697 | |
dc.language.iso | en | en_GB |
dc.publisher | American Association for the Advancement of Science (AAAS) | en_GB |
dc.rights | © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC). https://creativecommons.org/licenses/by-nc/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license, which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited. | en_GB |
dc.title | Epitranscriptomic regulation of insecticide resistance | en_GB |
dc.type | Article | en_GB |
dc.date.available | 2021-05-17T07:54:01Z | |
dc.identifier.issn | 2375-2548 | |
exeter.article-number | ARTN eabe5903 | en_GB |
dc.description | This is the final version. Available on open access from AAAS via the DOI in this record | en_GB |
dc.description | Data and materials availability: All data needed to evaluate the conclusions in the paper are present in the paper and/or the Supplementary Materials. Additional data related to this paper may be requested from the authors. | en_GB |
dc.identifier.journal | Science Advances | en_GB |
dc.rights.uri | https://creativecommons.org/licenses/by-nc/4.0/ | en_GB |
dcterms.dateAccepted | 2021-03-16 | |
rioxxterms.version | VoR | en_GB |
rioxxterms.licenseref.startdate | 2021-05-05 | |
rioxxterms.type | Journal Article/Review | en_GB |
refterms.dateFCD | 2021-05-17T07:50:52Z | |
refterms.versionFCD | VoR | |
refterms.dateFOA | 2021-05-17T07:54:07Z | |
refterms.panel | A | en_GB |
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Except where otherwise noted, this item's licence is described as © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC). https://creativecommons.org/licenses/by-nc/4.0/
This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license, which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited.