Omics Approaches for Understanding Biogenesis, Composition and Functions of Fungal Extracellular Vesicles
dc.contributor.author | Zamith-Miranda, D | |
dc.contributor.author | Peres da Silva, R | |
dc.contributor.author | Couvillion, SP | |
dc.contributor.author | Bredeweg, EL | |
dc.contributor.author | Burnet, MC | |
dc.contributor.author | Coelho, C | |
dc.contributor.author | Camacho, E | |
dc.contributor.author | Nimrichter, L | |
dc.contributor.author | Puccia, R | |
dc.contributor.author | Almeida, IC | |
dc.contributor.author | Casadevall, A | |
dc.contributor.author | Rodrigues, ML | |
dc.contributor.author | Alves, LR | |
dc.contributor.author | Nosanchuk, JD | |
dc.contributor.author | Nakayasu, ES | |
dc.date.accessioned | 2021-05-18T07:45:28Z | |
dc.date.issued | 2021-05-03 | |
dc.description.abstract | Extracellular vesicles (EVs) are lipid bilayer structures released by organisms from all kingdoms of life. The diverse biogenesis pathways of EVs result in a wide variety of physical properties and functions across different organisms. Fungal EVs were first described in 2007 and different omics approaches have been fundamental to understand their composition, biogenesis, and function. In this review, we discuss the role of omics in elucidating fungal EVs biology. Transcriptomics, proteomics, metabolomics, and lipidomics have each enabled the molecular characterization of fungal EVs, providing evidence that these structures serve a wide array of functions, ranging from key carriers of cell wall biosynthetic machinery to virulence factors. Omics in combination with genetic approaches have been instrumental in determining both biogenesis and cargo loading into EVs. We also discuss how omics technologies are being employed to elucidate the role of EVs in antifungal resistance, disease biomarkers, and their potential use as vaccines. Finally, we review recent advances in analytical technology and multi-omic integration tools, which will help to address key knowledge gaps in EVs biology and translate basic research information into urgently needed clinical applications such as diagnostics, and immuno- and chemotherapies to fungal infections. | en_GB |
dc.description.sponsorship | NIH | en_GB |
dc.description.sponsorship | Pacific Northwest National Laboratory (PNNL) | en_GB |
dc.description.sponsorship | CNPq/Science Without Borders Science Program, Brazil | en_GB |
dc.description.sponsorship | Johns Hopkins Malaria Research Institute | en_GB |
dc.description.sponsorship | FAPESP | en_GB |
dc.description.sponsorship | CAPES | en_GB |
dc.description.sponsorship | CNPq | en_GB |
dc.description.sponsorship | Medical Research Council (MRC) | en_GB |
dc.identifier.citation | Vol. 12, article 648524 | en_GB |
dc.identifier.doi | 10.3389/fgene.2021.648524 | |
dc.identifier.grantnumber | R21 AI124797 | en_GB |
dc.identifier.grantnumber | AI052733 | en_GB |
dc.identifier.grantnumber | AI15207 | en_GB |
dc.identifier.grantnumber | HL059842 | en_GB |
dc.identifier.grantnumber | 5U54MD007592 | en_GB |
dc.identifier.grantnumber | Casadevall_123 | en_GB |
dc.identifier.grantnumber | MR/N006364/2 | en_GB |
dc.identifier.uri | http://hdl.handle.net/10871/125729 | |
dc.language.iso | en | en_GB |
dc.publisher | Frontiers Media | en_GB |
dc.rights | © 2021 Zamith-Miranda, Peres da Silva, Couvillion, Bredeweg, Burnet, Coelho, Camacho, Nimrichter, Puccia, Almeida, Casadevall, Rodrigues, Alves, Nosanchuk and Nakayasu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. | en_GB |
dc.subject | extracellular vesicles | en_GB |
dc.subject | fungi | en_GB |
dc.subject | virulence | en_GB |
dc.subject | systems biology | en_GB |
dc.subject | proteomics | en_GB |
dc.subject | metabolomics | en_GB |
dc.subject | lipidomics | en_GB |
dc.subject | transcriptomics | en_GB |
dc.title | Omics Approaches for Understanding Biogenesis, Composition and Functions of Fungal Extracellular Vesicles | en_GB |
dc.type | Article | en_GB |
dc.date.available | 2021-05-18T07:45:28Z | |
dc.description | This is the final version. Available on open access from Frontiers Media via the DOI in this record | en_GB |
dc.identifier.eissn | 1664-8021 | |
dc.identifier.journal | Frontiers in Genetics | en_GB |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | en_GB |
dcterms.dateAccepted | 2021-04-06 | |
rioxxterms.version | VoR | en_GB |
rioxxterms.licenseref.startdate | 2021-05-03 | |
rioxxterms.type | Journal Article/Review | en_GB |
refterms.dateFCD | 2021-05-18T07:40:37Z | |
refterms.versionFCD | VoR | |
refterms.dateFOA | 2021-05-18T07:45:57Z | |
refterms.panel | A | en_GB |
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Except where otherwise noted, this item's licence is described as © 2021 Zamith-Miranda, Peres da Silva, Couvillion, Bredeweg, Burnet, Coelho, Camacho, Nimrichter, Puccia, Almeida, Casadevall, Rodrigues, Alves, Nosanchuk and Nakayasu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.