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Immune cells fold and damage fungal hyphae

dc.contributor.authorBain, JM
dc.contributor.authorAlonso, MF
dc.contributor.authorChilders, DS
dc.contributor.authorWalls, CA
dc.contributor.authorMackenzie, K
dc.contributor.authorPradhan, A
dc.contributor.authorLewis, LE
dc.contributor.authorLouw, J
dc.contributor.authorAvelar, GM
dc.contributor.authorLarcombe, DE
dc.contributor.authorNetea, MG
dc.contributor.authorGow, NAR
dc.contributor.authorBrown, GD
dc.contributor.authorErwig, LP
dc.contributor.authorBrown, AJP
dc.date.accessioned2021-05-20T12:03:52Z
dc.date.issued2021-04-05
dc.description.abstractInnate immunity provides essential protection against life-threatening fungal infections. However, the outcomes of individual skirmishes between immune cells and fungal pathogens are not a foregone conclusion because some pathogens have evolved mechanisms to evade phagocytic recognition, engulfment, and killing. For example, Candida albicans can escape phagocytosis by activating cellular morphogenesis to form lengthy hyphae that are challenging to engulf. Through live imaging of C. albicans-macrophage interactions, we discovered that macrophages can counteract this by folding fungal hyphae. The folding of fungal hyphae is promoted by Dectin-1, β2-integrin, VASP, actin-myosin polymerization, and cell motility. Folding facilitates the complete engulfment of long hyphae in some cases and it inhibits hyphal growth, presumably tipping the balance toward successful fungal clearance.en_GB
dc.description.sponsorshipMedical Research Council (MRC)en_GB
dc.description.sponsorshipWellcome Trusten_GB
dc.description.sponsorshipEuropean Research Council (ERC)en_GB
dc.description.sponsorshipNetherlands Organization for Scientific Researchen_GB
dc.identifier.citationVol. 118 (15), article e2020484118en_GB
dc.identifier.doi10.1073/pnas.2020484118
dc.identifier.grantnumberMR/M026663/1en_GB
dc.identifier.grantnumberMR/M026663/2en_GB
dc.identifier.grantnumberMR/N006364/1en_GB
dc.identifier.grantnumberMR/N006364/2en_GB
dc.identifier.grantnumber097377en_GB
dc.identifier.grantnumber101873en_GB
dc.identifier.grantnumber200208en_GB
dc.identifier.grantnumber102705en_GB
dc.identifier.grantnumber833247en_GB
dc.identifier.urihttp://hdl.handle.net/10871/125767
dc.language.isoenen_GB
dc.publisherNational Academy of Sciencesen_GB
dc.rights© 2021 the Author(s). Published by PNAS. This open access article is distributed under Creative Commons Attribution License 4.0 (CC BY).en_GB
dc.subjectmacrophagesen_GB
dc.subjectfungal hyphaeen_GB
dc.subjectmechanical forceen_GB
dc.subjectpodosomesen_GB
dc.subjectcytoskeletonen_GB
dc.titleImmune cells fold and damage fungal hyphaeen_GB
dc.typeArticleen_GB
dc.date.available2021-05-20T12:03:52Z
dc.identifier.issn0027-8424
dc.descriptionThis is the final version. Available on open access from the Evolutionary Computation Journal via the DOI in this recorden_GB
dc.descriptionData Availability: All study data are included in the article and/or supporting information.en_GB
dc.identifier.journalProceedings of the National Academy of Sciencesen_GB
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en_GB
dcterms.dateAccepted2021-02-20
rioxxterms.versionVoRen_GB
rioxxterms.licenseref.startdate2021-04-05
rioxxterms.typeJournal Article/Reviewen_GB
refterms.dateFCD2021-05-20T12:00:04Z
refterms.versionFCDVoR
refterms.dateFOA2021-05-20T12:04:06Z
refterms.panelAen_GB


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© 2021 the Author(s). Published by PNAS. This open access article is distributed under Creative Commons Attribution License 4.0 (CC BY).
Except where otherwise noted, this item's licence is described as © 2021 the Author(s). Published by PNAS. This open access article is distributed under Creative Commons Attribution License 4.0 (CC BY).