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dc.contributor.authorWhiting, JR
dc.contributor.authorParis, JR
dc.contributor.authorvan der Zee, MJ
dc.contributor.authorParsons, PJ
dc.contributor.authorWeigel, D
dc.contributor.authorFraser, BA
dc.date.accessioned2021-05-26T09:37:58Z
dc.date.issued2021-05-24
dc.description.abstractStudies of convergence in wild populations have been instrumental in understanding adaptation by providing strong evidence for natural selection. At the genetic level, we are beginning to appreciate that the re-use of the same genes in adaptation occurs through different mechanisms and can be constrained by underlying trait architectures and demographic characteristics of natural populations. Here, we explore these processes in naturally adapted high- (HP) and low-predation (LP) populations of the Trinidadian guppy, Poecilia reticulata. As a model for phenotypic change this system provided some of the earliest evidence of rapid and repeatable evolution in vertebrates; the genetic basis of which has yet to be studied at the whole-genome level. We collected whole-genome sequencing data from ten populations (176 individuals) representing five independent HP-LP river pairs across the three main drainages in Northern Trinidad. We evaluate population structure, uncovering several LP bottlenecks and variable between-river introgression that can lead to constraints on the sharing of adaptive variation between populations. Consequently, we found limited selection on common genes or loci across all drainages. Using a pathway type analysis, however, we find evidence of repeated selection on different genes involved in cadherin signaling. Finally, we found a large repeatedly selected haplotype on chromosome 20 in three rivers from the same drainage. Taken together, despite limited sharing of adaptive variation among rivers, we found evidence of convergent evolution associated with HP-LP environments in pathways across divergent drainages and at a previously unreported candidate haplotype within a drainage.en_GB
dc.description.sponsorshipH2020 European Research Councilen_GB
dc.description.sponsorshipNatural Environment Research Councilen_GB
dc.identifier.citationVol. 17, No. 5, article e1009566en_GB
dc.identifier.doi10.1371/journal.pgen.1009566
dc.identifier.grantnumberGUPPYCon 758382en_GB
dc.identifier.grantnumberNE/P013074/1en_GB
dc.identifier.urihttp://hdl.handle.net/10871/125835
dc.language.isoenen_GB
dc.publisherPublic Library of Scienceen_GB
dc.rightsCopyright: © 2021 Whiting et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en_GB
dc.titleDrainage-structuring of ancestral variation and a common functional pathway shape limited genomic convergence in natural high- and low-predation guppiesen_GB
dc.typeArticleen_GB
dc.date.available2021-05-26T09:37:58Z
dc.identifier.issn1553-7390
dc.descriptionThis is the final version. Available from Public Library of Science via the DOI in this record. en_GB
dc.descriptionData Availability: Raw sequencing reads are available on ENA: PRJEB43917 (Aripo, Madamas, Tacarigua) and PRJEB10680 (Guanapo and Oropouche). Final VCF data are available on FigShare, doi: 10.6084/m9.figshare.14315771. Other data and scripts used to analyse data are available on github: github.com/JimWhiting91/guppy_convergence. This repository is archived with Zenodo, doi: 10.5281/zenodo.4740381.en_GB
dc.identifier.eissn1553-7404
dc.identifier.journalPLOS Geneticsen_GB
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en_GB
dcterms.dateAccepted2021-04-27
exeter.funder::European Commissionen_GB
rioxxterms.versionVoRen_GB
rioxxterms.typeJournal Article/Reviewen_GB
refterms.dateFCD2021-05-26T09:28:22Z
refterms.versionFCDVoR
refterms.dateFOA2021-05-26T09:38:10Z
refterms.panelAen_GB


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Copyright: © 2021 Whiting et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Except where otherwise noted, this item's licence is described as Copyright: © 2021 Whiting et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.