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dc.contributor.authorHughes, AE
dc.contributor.authorDe Franco, E
dc.contributor.authorGloba, E
dc.contributor.authorZelinska, N
dc.contributor.authorHilgard, D
dc.contributor.authorSifianou, P
dc.contributor.authorHattersley, AT
dc.contributor.authorFlanagan, SE
dc.date.accessioned2021-06-23T14:23:05Z
dc.date.issued2021-06-04
dc.description.abstractHeterozygous mutations in GCK result in a persistent, mildly raised glucose from birth, but it is usually diagnosed in adulthood as maturity-onset diabetes of the young (MODY), where hyperglycemia is often an incidental finding. The hyperglycemia of GCK-MODY is benign and does not require treatment, but is important to be aware of, particularly in females where it has implications for managing pregnancy. We present three cases of neonatal hyperglycemia resulting from a heterozygous mutation in GCK, illustrating its clinical presentation and evolution in early life. In summary, as with adults, neonatal hyperglycemia is an incidental finding, does not require treatment and has no adverse consequences for health. Neonates and their parents should be referred for genetic testing to confirm the diagnosis, avoid a label of diabetes and enable pregnancy counselling for females found to be affected. This article is protected by copyright. All rights reserved.en_GB
dc.description.sponsorshipRoyal Societyen_GB
dc.description.sponsorshipNational Institute of Health Research (NIHR)en_GB
dc.description.sponsorshipDiabetes UKen_GB
dc.description.sponsorshipWellcome Trusten_GB
dc.identifier.citationPublished 4 June 2021en_GB
dc.identifier.doi10.1111/pedi.13239
dc.identifier.grantnumber105636/Z/14/Zen_GB
dc.identifier.urihttp://hdl.handle.net/10871/126160
dc.language.isoenen_GB
dc.publisherWiley / International Society for Pediatric and Adolescent Diabetesen_GB
dc.relation.urlhttps://www.ncbi.nlm.nih.gov/pubmed/34085361en_GB
dc.rights© 2021 The Authors. Pediatric Diabetes published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.en_GB
dc.subjectGCK-MODYen_GB
dc.subjectGlucokinaseen_GB
dc.subjecthyperglycemiaen_GB
dc.subjectmonogenic diabetes of the youngen_GB
dc.subjectneonatal diabetesen_GB
dc.titleIdentification of GCK-MODY in cases of neonatal hyperglycemia: a case series and review of clinical features.en_GB
dc.typeArticleen_GB
dc.date.available2021-06-23T14:23:05Z
dc.identifier.issn1399-543X
exeter.place-of-publicationDenmarken_GB
dc.descriptionThis is the final version. Available on open access from Wiley via the DOI in this record en_GB
dc.descriptionData availability statement: The data that supports this work is not freely available due to its identifiable nature, but reasonable requests for additional data can be made to the corresponding author.en_GB
dc.identifier.eissn1399-5448
dc.identifier.journalPediatric Diabetesen_GB
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en_GB
dcterms.dateAccepted2021-05-24
rioxxterms.versionVoRen_GB
rioxxterms.licenseref.startdate2021-06-04
rioxxterms.typeJournal Article/Reviewen_GB
refterms.dateFCD2021-06-23T14:11:50Z
refterms.versionFCDVoR
refterms.dateFOA2021-06-23T14:23:18Z
refterms.panelAen_GB


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© 2021 The Authors. Pediatric Diabetes published by John Wiley & Sons Ltd.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Except where otherwise noted, this item's licence is described as © 2021 The Authors. Pediatric Diabetes published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.