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Coevolution between bacterial CRISPR-Cas systems and their bacteriophages

dc.contributor.authorWatson, BNJ
dc.contributor.authorSteens, JA
dc.contributor.authorStaals, RHJ
dc.contributor.authorWestra, ER
dc.contributor.authorvan Houte, S
dc.date.accessioned2021-07-07T08:56:08Z
dc.date.issued2021-05-12
dc.description.abstractCRISPR-Cas systems provide bacteria and archaea with adaptive, heritable immunity against their viruses (bacteriophages and phages) and other parasitic genetic elements. CRISPR-Cas systems are highly diverse, and we are only beginning to understand their relative importance in phage defense. In this review, we will discuss when and why CRISPR-Cas immunity against phages evolves, and how this, in turn, selects for the evolution of immune evasion by phages. Finally, we will discuss our current understanding of if, and when, we observe coevolution between CRISPR-Cas systems and phages, and how this may be influenced by the mechanism of CRISPR-Cas immunity.en_GB
dc.description.sponsorshipVENIen_GB
dc.description.sponsorshipBiotechnology and Biological Sciences Research Councilen_GB
dc.description.sponsorshipBiotechnology and Biological Sciences Research Councilen_GB
dc.identifier.citationVol. 29 (5), pp. 715 - 725en_GB
dc.identifier.doi10.1016/j.chom.2021.03.018
dc.identifier.grantnumber016.Veni.171.047en_GB
dc.identifier.grantnumberBB/S017674/1en_GB
dc.identifier.grantnumberBB/R010781/10en_GB
dc.identifier.urihttp://hdl.handle.net/10871/126331
dc.language.isoenen_GB
dc.publisherCell Pressen_GB
dc.rights.embargoreasonUnder embargo until 12 May 2022 in compliance with publisher policyen_GB
dc.rights© 2021 Elsevier Inc.. This version is made available under the CC-BY-NC-ND 4.0 license: https://creativecommons.org/licenses/by-nc-nd/4.0/  en_GB
dc.subjectCRISPR-Casen_GB
dc.subjectbacteriophagesen_GB
dc.subjectcoevolutionen_GB
dc.subjectecologyen_GB
dc.subjectevolutionen_GB
dc.titleCoevolution between bacterial CRISPR-Cas systems and their bacteriophagesen_GB
dc.typeArticleen_GB
dc.date.available2021-07-07T08:56:08Z
dc.identifier.issn1931-3128
dc.descriptionThis is the author accepted manuscript. The final version is available from Cell Press via the DOI in this record en_GB
dc.identifier.eissn1934-6069
dc.identifier.journalCell Host and Microbeen_GB
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/  en_GB
rioxxterms.funderNatural Environment Research Councilen_GB
rioxxterms.funderNatural Environment Research Councilen_GB
rioxxterms.funderEuropean Research Councilen_GB
rioxxterms.identifier.projectNE/S001921/1en_GB
rioxxterms.identifier.projectNE/M018350/1en_GB
rioxxterms.identifier.projectERC-STG-2016-714478—EVOIMMECHen_GB
rioxxterms.versionAMen_GB
rioxxterms.licenseref.startdate2021-05-12
rioxxterms.typeJournal Article/Reviewen_GB
refterms.dateFCD2021-07-07T06:59:35Z
refterms.versionFCDAM
refterms.dateFOA2022-05-11T23:00:00Z
refterms.panelAen_GB
rioxxterms.funder.projectdbbc8c72-9b67-4440-a4b4-bb5b8bcf394aen_GB
rioxxterms.funder.projectebf7243b-791d-4b55-acba-3bfbfb4acfcaen_GB
rioxxterms.funder.project274d6f03-d6e0-424d-ad6c-f0bf754976f0en_GB


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© 2021 Elsevier Inc.. This version is made available under the CC-BY-NC-ND 4.0 license: https://creativecommons.org/licenses/by-nc-nd/4.0/  
Except where otherwise noted, this item's licence is described as © 2021 Elsevier Inc.. This version is made available under the CC-BY-NC-ND 4.0 license: https://creativecommons.org/licenses/by-nc-nd/4.0/