Global patterns in genomic diversity underpinning the evolution of insecticide resistance in the aphid crop pest Myzus persicae
dc.contributor.author | Singh, KS | |
dc.contributor.author | Cordeiro, EMG | |
dc.contributor.author | Troczka, BJ | |
dc.contributor.author | Pym, A | |
dc.contributor.author | Mackisack, J | |
dc.contributor.author | Mathers, TC | |
dc.contributor.author | Duarte, A | |
dc.contributor.author | Legeai, F | |
dc.contributor.author | Robin, S | |
dc.contributor.author | Bielza, P | |
dc.contributor.author | Burrack, HJ | |
dc.contributor.author | Charaabi, K | |
dc.contributor.author | Denholm, I | |
dc.contributor.author | Figueroa, CC | |
dc.contributor.author | Ffrench-Constant, RH | |
dc.contributor.author | Jander, G | |
dc.contributor.author | Margaritopoulos, JT | |
dc.contributor.author | Mazzoni, E | |
dc.contributor.author | Nauen, R | |
dc.contributor.author | Ramírez, CC | |
dc.contributor.author | Ren, G | |
dc.contributor.author | Stepanyan, I | |
dc.contributor.author | Umina, PA | |
dc.contributor.author | Voronova, NV | |
dc.contributor.author | Vontas, J | |
dc.contributor.author | Williamson, MS | |
dc.contributor.author | Wilson, ACC | |
dc.contributor.author | Xi-Wu, G | |
dc.contributor.author | Youn, Y-N | |
dc.contributor.author | Zimmer, CT | |
dc.contributor.author | Simon, J-C | |
dc.contributor.author | Hayward, A | |
dc.contributor.author | Bass, C | |
dc.date.accessioned | 2021-07-12T07:13:54Z | |
dc.date.issued | 2021-07-07 | |
dc.description.abstract | The aphid Myzus persicae is a destructive agricultural pest that displays an exceptional ability to develop resistance to both natural and synthetic insecticides. To investigate the evolution of resistance in this species we generated a chromosome-scale genome assembly and living panel of >110 fully sequenced globally sampled clonal lines. Our analyses reveal a remarkable diversity of resistance mutations segregating in global populations of M. persicae. We show that the emergence and spread of these mechanisms is influenced by host-plant associations, uncovering the widespread co-option of a host-plant adaptation that also offers resistance against synthetic insecticides. We identify both the repeated evolution of independent resistance mutations at the same locus, and multiple instances of the evolution of novel resistance mechanisms against key insecticides. Our findings provide fundamental insights into the genomic responses of global insect populations to strong selective forces, and hold practical relevance for the control of pests and parasites. | en_GB |
dc.description.sponsorship | European Union Horizon 2020 | en_GB |
dc.description.sponsorship | Biotechnology and Biological Sciences Research Council (BBSRC) | en_GB |
dc.description.sponsorship | Defense Advanced Research Projects Agency (DARPA) | en_GB |
dc.description.sponsorship | National Science Foundation (NSF) | en_GB |
dc.identifier.citation | Vol. 4, article 847 | en_GB |
dc.identifier.doi | 10.1038/s42003-021-02373-x | |
dc.identifier.grantnumber | 646625 | en_GB |
dc.identifier.grantnumber | BB/S006060/1 | en_GB |
dc.identifier.grantnumber | HR0011-17-2-0053 | en_GB |
dc.identifier.grantnumber | IOS-1354154 | en_GB |
dc.identifier.grantnumber | BB/N020146/1 | en_GB |
dc.identifier.grantnumber | BB/R01227X/1 | en_GB |
dc.identifier.uri | http://hdl.handle.net/10871/126369 | |
dc.language.iso | en | en_GB |
dc.publisher | Nature Research | en_GB |
dc.relation.url | https://www.ncbi.nlm.nih.gov/pubmed/34234279 | en_GB |
dc.relation.url | https://bipaa.genouest.org/is/aphidbase/108 | en_GB |
dc.relation.url | https://doi.org/10.5061/dryad.vhhmgqnt7 | en_GB |
dc.rights | © The Author(s) 2021. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. | en_GB |
dc.title | Global patterns in genomic diversity underpinning the evolution of insecticide resistance in the aphid crop pest Myzus persicae | en_GB |
dc.type | Article | en_GB |
dc.date.available | 2021-07-12T07:13:54Z | |
exeter.place-of-publication | England | en_GB |
dc.description | This is the final version. Available on open access from Nature Research via the DOI in this record | en_GB |
dc.description | Data availability: The sequence data generated in this study has been deposited with NCBI under the Bio Project ID: PRJNA574571107. For individual accession numbers associated with each clone see Supplementary Data 1. The genome assembly of M. persicae clone G006 is also available at AphidBase https://bipaa.genouest.org/is/aphidbase/108. Source data for figures are available in Supplementary Data 1 and on Dryad https://doi.org/10.5061/dryad.vhhmgqnt7. All other data generated during the current study is available from the corresponding author on reasonable request. | en_GB |
dc.identifier.eissn | 2399-3642 | |
dc.identifier.journal | Communications Biology | en_GB |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | en_GB |
dcterms.dateAccepted | 2021-06-17 | |
rioxxterms.version | VoR | en_GB |
rioxxterms.licenseref.startdate | 2021-07-07 | |
rioxxterms.type | Journal Article/Review | en_GB |
refterms.dateFCD | 2021-07-12T07:11:18Z | |
refterms.versionFCD | VoR | |
refterms.dateFOA | 2021-07-12T07:17:30Z | |
refterms.panel | A | en_GB |
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Except where otherwise noted, this item's licence is described as © The Author(s) 2021. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.