Neuropsychological Impairments and their cognitive architecture in Mild Cognitive Impairment (MCI) with Lewy Bodies and MCI-Alzheimer’s Disease
dc.contributor.author | Ciafone, J | |
dc.contributor.author | Thomas, A | |
dc.contributor.author | Durcan, R | |
dc.contributor.author | Donaghy, PC | |
dc.contributor.author | Hamilton, CA | |
dc.contributor.author | Lawley, S | |
dc.contributor.author | Roberts, G | |
dc.contributor.author | Colloby, S | |
dc.contributor.author | Firbank, MJ | |
dc.contributor.author | Allan, L | |
dc.contributor.author | Petrides, G | |
dc.contributor.author | Taylor, J-P | |
dc.contributor.author | O'Brien, J | |
dc.contributor.author | Gallagher, P | |
dc.date.accessioned | 2021-08-31T12:38:26Z | |
dc.date.issued | 2021-10-20 | |
dc.description.abstract | Objective: The present study aimed to clarify the neuropsychological profile of the emergent diagnostic category of Mild Cognitive Impairment with Lewy bodies (MCI-LB) and determine whether domain-specific impairments such as in memory were related to deficits in domain-general cognitive processes (executive function or processing speed). Method: Patients (n=83) and healthy age- and sex-matched controls (n=34) underwent clinical and imaging assessments. Probable MCI-LB (n=44) and MCI-AD (n=39) were diagnosed following National Institute on Aging-Alzheimer’s Association (NIA-AA) and DLB consortium criteria. Neuropsychological measures included cognitive and psychomotor speed, executive function, working memory, and verbal and visuospatial recall. Results: MCI-LB scored significantly lower than MCI-AD on processing speed (Trail Making Test B: p=0.03, g=0.45; Digit Symbol Substitution Test [DSST]: p=0.04, g=0.47; DSST Error Check: p<0.001, g=0.68) and executive function (Trail Making Test Ratio [A/B]: p=0.04, g=0.52) tasks. MCI-AD performed worse than MCI-LB on memory tasks, specifically visuospatial (Modified Taylor Complex Figure: p=0.01, g=0.46) and verbal (Rey Auditory Verbal Learning Test: p=0.04, g=0.42) delayed recall measures. Stepwise discriminant analysis correctly classified the subtype in 65.1% of MCI patients (72.7% specificity, 56.4% sensitivity). Processing speed accounted for more group-associated variance in visuospatial and verbal memory in both MCI subtypes than executive function, while no significant relationships between measures were observed in controls (all ps>.05) Conclusions: MCI-LB was characterised by executive dysfunction and slowed processing speed but did not show the visuospatial dysfunction expected, whilst MCI-AD displayed an amnestic profile. However, there was considerable neuropsychological profile overlap and processing speed mediated performance in both MCI subtypes. | en_GB |
dc.description.sponsorship | Alzheimer’s Research UK | en_GB |
dc.description.sponsorship | Medical Research Council (MRC) | en_GB |
dc.description.sponsorship | GE Healthcare | en_GB |
dc.description.sponsorship | Alzheimer’s Society | en_GB |
dc.description.sponsorship | National Institute for Health Research (NIHR) | en_GB |
dc.identifier.citation | Published online 20 October 2021 | en_GB |
dc.identifier.doi | 10.1017/S1355617721001181 | |
dc.identifier.grantnumber | ARUK-PG2015-13 | en_GB |
dc.identifier.uri | http://hdl.handle.net/10871/126941 | |
dc.language.iso | en | en_GB |
dc.publisher | Cambridge University Press / International Neuropsychological Society | en_GB |
dc.rights | © INS. Published by Cambridge University Press, 2021. This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited. | en_GB |
dc.subject | Cognitive Dysfunction | en_GB |
dc.subject | Cognition | en_GB |
dc.subject | Learning | en_GB |
dc.subject | Executive Function | en_GB |
dc.subject | Lewy Body Disease | en_GB |
dc.subject | Dementia | en_GB |
dc.title | Neuropsychological Impairments and their cognitive architecture in Mild Cognitive Impairment (MCI) with Lewy Bodies and MCI-Alzheimer’s Disease | en_GB |
dc.type | Article | en_GB |
dc.date.available | 2021-08-31T12:38:26Z | |
dc.identifier.issn | 1355-6177 | |
dc.description | This is the final version. Available on open access from Cambridge University Press via the DOI in this record | en_GB |
dc.identifier.journal | Journal of the International Neuropsychological Society | en_GB |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | en_GB |
dcterms.dateAccepted | 2021-08-13 | |
rioxxterms.version | VoR | en_GB |
rioxxterms.licenseref.startdate | 2021-08-13 | |
rioxxterms.type | Journal Article/Review | en_GB |
refterms.dateFCD | 2021-08-31T10:13:26Z | |
refterms.versionFCD | AM | |
refterms.dateFOA | 2021-10-29T14:35:40Z | |
refterms.panel | A | en_GB |
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Except where otherwise noted, this item's licence is described as © INS. Published by Cambridge University Press, 2021. This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.