Genetic determinants of daytime napping and effects on cardiometabolic health
dc.contributor.author | Dashti, HS | |
dc.contributor.author | Daghlas, I | |
dc.contributor.author | Lane, JM | |
dc.contributor.author | Huang, Y | |
dc.contributor.author | Udler, MS | |
dc.contributor.author | Wang, H | |
dc.contributor.author | Ollila, HM | |
dc.contributor.author | Jones, SE | |
dc.contributor.author | Kim, J | |
dc.contributor.author | Wood, AR | |
dc.contributor.author | Agee, M | |
dc.contributor.author | Auton, A | |
dc.contributor.author | Bell, RK | |
dc.contributor.author | Bryc, K | |
dc.contributor.author | Clark, SK | |
dc.contributor.author | Elson, SL | |
dc.contributor.author | Fletez-Brant, K | |
dc.contributor.author | Fontanillas, P | |
dc.contributor.author | Furlotte, NA | |
dc.contributor.author | Gandhi, PM | |
dc.contributor.author | Heilbron, K | |
dc.contributor.author | Hicks, B | |
dc.contributor.author | Hinds, DA | |
dc.contributor.author | Huber, KE | |
dc.contributor.author | Jewett, EM | |
dc.contributor.author | Jiang, Y | |
dc.contributor.author | Kleinman, A | |
dc.contributor.author | Lin, KH | |
dc.contributor.author | Litterman, NK | |
dc.contributor.author | Luff, MK | |
dc.contributor.author | McCreight, JC | |
dc.contributor.author | McIntyre, MH | |
dc.contributor.author | McManus, KF | |
dc.contributor.author | Mountain, JL | |
dc.contributor.author | Mozaffari, SV | |
dc.contributor.author | Nandakumar, P | |
dc.contributor.author | Noblin, ES | |
dc.contributor.author | Northover, CAM | |
dc.contributor.author | O’Connell, J | |
dc.contributor.author | Petrakovitz, AA | |
dc.contributor.author | Pitts, SJ | |
dc.contributor.author | Poznik, GD | |
dc.contributor.author | Sathirapongsasuti, JF | |
dc.contributor.author | Shastri, AJ | |
dc.contributor.author | Shelton, JF | |
dc.contributor.author | Shringarpure, S | |
dc.contributor.author | Tian, C | |
dc.contributor.author | Tung, JY | |
dc.contributor.author | Tunney, RJ | |
dc.contributor.author | Vacic, V | |
dc.contributor.author | Wang, X | |
dc.contributor.author | Zare, AS | |
dc.contributor.author | Weedon, MN | |
dc.contributor.author | Aslibekyan, S | |
dc.contributor.author | Garaulet, M | |
dc.contributor.author | Saxena, R | |
dc.date.accessioned | 2021-09-10T13:50:30Z | |
dc.date.issued | 2021-02-10 | |
dc.description.abstract | Daytime napping is a common, heritable behavior, but its genetic basis and causal relationship with cardiometabolic health remain unclear. Here, we perform a genome-wide association study of self-reported daytime napping in the UK Biobank (n = 452,633) and identify 123 loci of which 61 replicate in the 23andMe research cohort (n = 541,333). Findings include missense variants in established drug targets for sleep disorders (HCRTR1, HCRTR2), genes with roles in arousal (TRPC6, PNOC), and genes suggesting an obesity-hypersomnolence pathway (PNOC, PATJ). Association signals are concordant with accelerometer-measured daytime inactivity duration and 33 loci colocalize with loci for other sleep phenotypes. Cluster analysis identifies three distinct clusters of nap-promoting mechanisms with heterogeneous associations with cardiometabolic outcomes. Mendelian randomization shows potential causal links between more frequent daytime napping and higher blood pressure and waist circumference. | en_GB |
dc.description.sponsorship | National Institute of Health | en_GB |
dc.description.sponsorship | National Institute of Health | en_GB |
dc.description.sponsorship | National Institute of Health | en_GB |
dc.description.sponsorship | National Institute of Health | en_GB |
dc.description.sponsorship | National Institute of Health | en_GB |
dc.description.sponsorship | MGH Research Scholar Fund, Academy of Finland | en_GB |
dc.description.sponsorship | Medical Research Council | en_GB |
dc.description.sponsorship | Spanish Government of Investigation, Development and Innovation | en_GB |
dc.description.sponsorship | Seneca Foundation | en_GB |
dc.description.sponsorship | NIDDK | en_GB |
dc.description.sponsorship | Instrumentarium Science Foundation | en_GB |
dc.description.sponsorship | Yrjö Jahnsson Foundation | en_GB |
dc.identifier.citation | Vol. 12, article 900 | en_GB |
dc.identifier.doi | 10.1038/s41467-020-20585-3 | |
dc.identifier.grantnumber | NIH-F32DK102323 | en_GB |
dc.identifier.grantnumber | NIH-4T32HL007901 | en_GB |
dc.identifier.grantnumber | NIH-R01DK107859 | en_GB |
dc.identifier.grantnumber | NIH-R35HL135818 | en_GB |
dc.identifier.grantnumber | NIH-K23DK114551 | en_GB |
dc.identifier.grantnumber | 309643 | en_GB |
dc.identifier.grantnumber | MR/M005070/1 | en_GB |
dc.identifier.grantnumber | SAF2017-84135-R | en_GB |
dc.identifier.grantnumber | 20795/PI/18 | en_GB |
dc.identifier.grantnumber | R01DK105072 | en_GB |
dc.identifier.uri | http://hdl.handle.net/10871/127053 | |
dc.language.iso | en | en_GB |
dc.publisher | Nature Research | en_GB |
dc.rights | © The Author(s) 2021. Open Access: This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/ licenses/by/4.0/. | en_GB |
dc.subject | Endocrine system and metabolic diseases | en_GB |
dc.subject | Genome-wide association studies | en_GB |
dc.subject | Sleep | en_GB |
dc.title | Genetic determinants of daytime napping and effects on cardiometabolic health | en_GB |
dc.type | Article | en_GB |
dc.date.available | 2021-09-10T13:50:30Z | |
dc.identifier.issn | 2041-1723 | |
dc.description | This is the final version. Available from Nature Research via the DOI in this record. | en_GB |
dc.description | Summary GWAS statistics are publicly available at The Sleep Disorder Knowledge Portal webpage: http://sleepdisordergenetics.org/. | en_GB |
dc.identifier.journal | Nature Communications | en_GB |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | en_GB |
dcterms.dateAccepted | 2020-12-08 | |
exeter.funder | ::Medical Research Council (MRC) | en_GB |
exeter.funder | ::Diabetes UK | en_GB |
rioxxterms.version | VoR | en_GB |
rioxxterms.licenseref.startdate | 2021-02-10 | |
rioxxterms.type | Journal Article/Review | en_GB |
refterms.dateFCD | 2021-09-10T13:42:08Z | |
refterms.versionFCD | VoR | |
refterms.dateFOA | 2021-09-10T13:50:35Z | |
refterms.panel | A | en_GB |
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Commons license, and indicate if changes were made. The images or other third party
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article’s Creative Commons license and your intended use is not permitted by statutory
regulation or exceeds the permitted use, you will need to obtain permission directly from
the copyright holder. To view a copy of this license, visit http://creativecommons.org/
licenses/by/4.0/.