The value of insulin degludec in frail older adults with type 2 diabetes
dc.contributor.author | Strain, WD | |
dc.contributor.author | Morgan, AR | |
dc.contributor.author | Evans, M | |
dc.date.accessioned | 2021-09-29T14:33:42Z | |
dc.date.issued | 2021-10-04 | |
dc.description.abstract | Insulin represents a mainstay of glucose lowering therapy for many adults with type 2 diabetes mellitus (T2DM). Insulin treatments prescribed as standard care for the majority of people with T2DM, such as basal human insulin, may not be optimal in the treatment of frail older adults due to the increased demand on health care staff to administer multiple daily injections and monitor the patient. When choosing an insulin regimen for a frail older person with T2DM, predictability of glucose lowering effect, risk of hypoglycaemia, ease of administration, and simplicity and flexibility of dosing are major determining factors. Multiple daily injections may be too complex for older frail adults, whilst providing an unnecessary degree of tight glycaemic control, and low doses of once-daily basal insulin analogues such as insulin degludec may be a reasonable option as cognitive decline or functional disability increases. Although insulin degludec has a substantially higher acquisition cost than routinely used basal human insulin, it has a longer, more predictable pharmacological profile, and is more amenable to once daily administration, translating into a reduced burden of care and potential cost savings for insulin treated frail older adults. Insulin acquisition cost represents only a small proportion of the total cost of treatment, and it is important to consider the value perspective of insulin therapy in frail older adults from all stakeholders in the healthcare system | en_GB |
dc.description.sponsorship | Novo Nordisk | en_GB |
dc.identifier.citation | Published online 4 October 2021 | en_GB |
dc.identifier.doi | 10.1007/s13300-021-01162-3 | |
dc.identifier.uri | http://hdl.handle.net/10871/127279 | |
dc.language.iso | en | en_GB |
dc.publisher | Springer | en_GB |
dc.rights | © The Author(s) 2021. Open Access. This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc/4.0/. | |
dc.subject | Frail Elderly | en_GB |
dc.subject | Health Care Costs | en_GB |
dc.subject | Human insulin | en_GB |
dc.subject | Insulin analogue | en_GB |
dc.subject | Insulin degludec | en_GB |
dc.subject | Type 2 diabetes mellitus | en_GB |
dc.title | The value of insulin degludec in frail older adults with type 2 diabetes | en_GB |
dc.type | Article | en_GB |
dc.date.available | 2021-09-29T14:33:42Z | |
dc.identifier.issn | 1869-6953 | |
dc.description | This is the final version. Available on open access from Springer via the DOI in this record | en_GB |
dc.description | Data availability: Data sharing is not applicable to this article as no datasets were generated or analysed during the current study. | en_GB |
dc.identifier.eissn | 1869-6961 | |
dc.identifier.journal | Diabetes Therapy | en_GB |
dc.rights.uri | https://creativecommons.org/licenses/by-nc/4.0/ | en_GB |
dcterms.dateAccepted | 2021-09-21 | |
rioxxterms.version | VoR | en_GB |
rioxxterms.licenseref.startdate | 2021-09-21 | |
rioxxterms.type | Journal Article/Review | en_GB |
refterms.dateFCD | 2021-09-29T13:37:38Z | |
refterms.versionFCD | AM | |
refterms.dateFOA | 2021-10-14T14:43:41Z | |
refterms.panel | A | en_GB |
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Except where otherwise noted, this item's licence is described as © The Author(s) 2021. Open Access. This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc/4.0/.