Introduction: The Community Ageing Research 75+
(CARE75+) study is a longitudinal cohort study collecting
extensive health and social data, with a focus on frailty,
independence and quality of life in older age. CARE75+
was the first international experimental frailty research
cohort designed using trial within cohorts ...
Introduction: The Community Ageing Research 75+
(CARE75+) study is a longitudinal cohort study collecting
extensive health and social data, with a focus on frailty,
independence and quality of life in older age. CARE75+
was the first international experimental frailty research
cohort designed using trial within cohorts (TwiCs)
methodology, aligning epidemiological research with
clinical trial evaluation of interventions to improve
the health and well-being of older people. CARE75+
REMOTE is an extension of CARE75+ using a remote
model that does not require face-to-face interactions for
data collection in the current circumstances of a global
pandemic and will provide an efficient, sustainable data
collection model.
Methods and analysis: Prospective cohort study using
TwiCs. One thousand community-dwelling older people
(≥75 years) will be recruited from UK general practices by
telephone. Exclusions include: nursing home/care home
residents; those with an estimated life expectancy of 3
months or less; and people receiving palliative care.
Data collection Assessments will be conducted by
telephone, web-submission or postal questionnaire:
baseline, 6 months, 12 months, 18 months, 24 months,
30 months and 36 months. Measures include activities
of daily living, mood, health-related quality of life,
comorbidities, medications, frailty, informal care,
healthcare and social care service use. Consent will be
sought for data linkage and invitations to additional studies
(sub-studies).
Ethics and dissemination: CARE75+was approved by
the National Research Ethics Service (NRES) Committee
Yorkshire and the Humber—Bradford Leeds 10 October
2014 (14/YH/1120). CARE75+REMOTE (amendment 13)
was approved on the 18th November 2020. Consent is
sought if an individual is willing to participate and has
capacity to provide informed consent. Consultee assent
is sought if an individual lacks capacity. Results will
be disseminated in peer-reviewed scientific journals
and conferences. Results will be summarised and
disseminated to study participants via newsletters, local
engagement events and on a bespoke website.
Trial registration number ISRCTN16588124.
