Effectiveness and cost-effectiveness of universal school-based mindfulness training compared with normal school provision in reducing risk of mental health problems and promoting well-being in adolescence: the MYRIAD cluster randomised controlled trial
dc.contributor.author | Kuyken, W | |
dc.contributor.author | Ball, S | |
dc.contributor.author | Crane, C | |
dc.contributor.author | Ganguli, P | |
dc.contributor.author | Jones, B | |
dc.contributor.author | Montero-Marin, J | |
dc.contributor.author | Nuthall, E | |
dc.contributor.author | Raja, A | |
dc.contributor.author | Taylor, L | |
dc.contributor.author | Tudor, K | |
dc.contributor.author | Viner, RM | |
dc.contributor.author | Allwood, M | |
dc.contributor.author | Aukland, L | |
dc.contributor.author | Dunning, D | |
dc.contributor.author | Casey, T | |
dc.contributor.author | Dalrymple, N | |
dc.contributor.author | De Wilde, K | |
dc.contributor.author | Farley, E-R | |
dc.contributor.author | Harper, J | |
dc.contributor.author | Kappelmann, N | |
dc.contributor.author | Kempnich, M | |
dc.contributor.author | Lord, L | |
dc.contributor.author | Medlicott, E | |
dc.contributor.author | Palmer, L | |
dc.contributor.author | Petit, A | |
dc.contributor.author | Philips, A | |
dc.contributor.author | Pryor-Nitsch, I | |
dc.contributor.author | Radley, L | |
dc.contributor.author | Sonley, A | |
dc.contributor.author | Shackleford, J | |
dc.contributor.author | Tickell, A | |
dc.contributor.author | Blakemore, S-J | |
dc.contributor.author | Ukoumunne, OC | |
dc.contributor.author | Greenberg, MT | |
dc.contributor.author | Ford, T | |
dc.contributor.author | Dalgleish, T | |
dc.contributor.author | Byford, S | |
dc.contributor.author | Williams, JMG | |
dc.date.accessioned | 2022-03-18T14:14:20Z | |
dc.date.issued | 2022-07-21 | |
dc.date.updated | 2022-03-07T11:25:30Z | |
dc.description.abstract | Background Systematic reviews suggest school-based mindfulness training (SBMT) shows promise in promoting student mental health. Objective The MYRIAD trial evaluated the effectiveness and cost-effectiveness of SBMT compared with teaching-as-usual (TAU). Methods MYRIAD was a parallel group, cluster-randomised controlled trial. Eighty-five eligible schools consented and were randomised 1:1 to TAU (43 schools, 4232 students) or SBMT (42 schools, 4144 students), stratified by school size, quality, type, deprivation, and region. Schools and students (mean (SD); range age=12.2, (0.6); 11-14) were broadly UK population-representative. Forty-three schools (n=3678 pupils; 86.9%) delivering SBMT, and 41 schools (n=3572; 86.2%) delivering TAU, provided primary end-point data. SBMT comprised ten lessons of psycho-education and mindfulness practices. TAU comprised standard social-emotional teaching. Participant-level risk-for-depression, social-emotionalbehavioural functioning, and well-being at one-year follow-up were the co-primary outcomes. Secondary and economic outcomes were included. 3 Findings: Analysis of 84 schools (N=8,376 participants) found no evidence that SBMT was superior to TAU at one-year. Standardised mean differences (intervention minus control) were: 0.005 (95%CI: -0.05–0.06) for risk-for-depression; 0.02 (-0.02–0.07) for socialemotional-behavioural functioning; and 0.02 (-0.03–0.07) for well-being. SBMT had a high probability of cost-effectiveness (83%) at a willingness-to-pay threshold of £20,000 per QALY. No intervention-related adverse events were observed. Conclusions: Findings do not support the superiority of SBMT over TAU in promoting mental health in adolescence. Clinical implications: There is need to ask what works, for whom and how, as well as considering key contextual and implementation factors. Trial registration: Current Controlled Trials ISRCTN86619085. | en_GB |
dc.description.sponsorship | Wellcome Trust | en_GB |
dc.identifier.citation | Vol. 25, pp. 99-109 | en_GB |
dc.identifier.doi | 10.1136/ebmental-2021-300396 | |
dc.identifier.grantnumber | WT104908/Z/14/Z | en_GB |
dc.identifier.grantnumber | WT107496/Z/15/Z | en_GB |
dc.identifier.uri | http://hdl.handle.net/10871/129085 | |
dc.identifier | ORCID: 0000-0002-0551-9157 (Ukoumunne, Obi) | |
dc.language.iso | en | en_GB |
dc.publisher | BMJ Publishing Group / Royal College of Psychiatrists / The British Psychological Society | en_GB |
dc.rights | © Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY. Published by BMJ. This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/ | en_GB |
dc.title | Effectiveness and cost-effectiveness of universal school-based mindfulness training compared with normal school provision in reducing risk of mental health problems and promoting well-being in adolescence: the MYRIAD cluster randomised controlled trial | en_GB |
dc.type | Article | en_GB |
dc.date.available | 2022-03-18T14:14:20Z | |
dc.identifier.issn | 1468-960X | |
dc.description | This is the final version. Available on open access from the BMJ Publishing Group via the DOI in this record | en_GB |
dc.description | Data Sharing Statement: the baseline data and codebook from the MYRIAD trial is available from Prof. Kuyken (willem.kuyken@psych.ox.ac.uk) upon request (release of data is subject to an approved proposal and a signed data access agreement) | en_GB |
dc.identifier.journal | Evidence-Based Mental Health | en_GB |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | en_GB |
dcterms.dateAccepted | 2022-03-03 | |
rioxxterms.version | VoR | en_GB |
rioxxterms.licenseref.startdate | 2022-03-03 | |
rioxxterms.type | Journal Article/Review | en_GB |
refterms.dateFCD | 2022-03-07T11:25:34Z | |
refterms.versionFCD | AM | |
refterms.dateFOA | 2022-03-18T14:14:25Z | |
refterms.panel | A | en_GB |
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This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/