Interclass Difference in Pneumonia Risk in COPD Patients Initiating Fixed Dose Inhaled Treatment Containing Extrafine Particle Beclometasone versus Fine Particle Fluticasone
dc.contributor.author | Price, DB | |
dc.contributor.author | Henley, W | |
dc.contributor.author | Cançado, JED | |
dc.contributor.author | Fabbri, LM | |
dc.contributor.author | Kerstjens, HAM | |
dc.contributor.author | Papi, A | |
dc.contributor.author | Roche, N | |
dc.contributor.author | Şen, E | |
dc.contributor.author | Singh, D | |
dc.contributor.author | Vogelmeier, CF | |
dc.contributor.author | Barille, S | |
dc.contributor.author | Nudo, E | |
dc.contributor.author | Carter, V | |
dc.contributor.author | Skinner, D | |
dc.contributor.author | Vella, R | |
dc.contributor.author | Georges, G | |
dc.date.accessioned | 2022-03-24T10:14:19Z | |
dc.date.issued | 2022-02-15 | |
dc.date.updated | 2022-03-24T09:07:56Z | |
dc.description.abstract | Background: Inhaled corticosteroids (ICS) afford therapeutic benefits in some COPD patients, but their widespread use is cautioned due to an increased risk of developing pneumonia. Subclass variations exist, and the risk profile differs for individual ICS. Formulation particle size has been identified as a potential effect modifier. The present study compared the risk of pneumonia among new COPD users of fixed-dose combination inhalers containing fine-particle fluticasone (fp-FDC-F) versus extrafine particle beclometasone (ef-FDC-BDP). Methods: A propensity matched historical cohort study was conducted using data from the Optimum Patient Care Research Database. COPD patients aged ≥40 years with ≥1 year of continuous medical data who initiated fp-FDC-F or ef-FDC-BDP were compared. The primary outcome was time to pneumonia event, as treated, using either sensitive (physician diagnosed) or specific (physician diagnosed and x-ray or hospital admission confirmed) definitions. Results: A total of 13,316 patients were matched. Initiation of fp-FDC-F (mean dosage furoate 99 µg; propionate 710 µg) was associated with an increased risk of pneumonia versus ef-FDC-BDP (mean beclometasone dose 395 µg), irrespective of definition (sensitive HR 1.38 95% CI 1.14-1.68; specific HR 1.31 95% CI 1.05-1.62). Conclusion: In the current investigation, we found that in comparison to extrafine beclomethasone, commencing a formulation containing fluticasone is associated with an increased risk of developing pneumonia. These observations support the idea that not all ICS are equal in their adverse effects and subclass variations exist and should be carefully considered in the treatment choice. | en_GB |
dc.description.sponsorship | Chiesi Farmaceutici S.p.A. | en_GB |
dc.format.extent | 355-370 | |
dc.identifier.citation | Vol. 17, pp. 355-370 | en_GB |
dc.identifier.doi | https://doi.org/10.2147/COPD.S342357 | |
dc.identifier.uri | http://hdl.handle.net/10871/129142 | |
dc.identifier | ORCID: 0000-0001-6273-2619 (Henley, William) | |
dc.language.iso | en | en_GB |
dc.publisher | Dove Press | en_GB |
dc.relation.url | https://www.ncbi.nlm.nih.gov/pubmed/35210765 | en_GB |
dc.rights | ©2022 Price et al. This work is published and licensed by Dove Medical Press Limited. Open access. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution–Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). | en_GB |
dc.subject | COPD | en_GB |
dc.subject | extrafine beclomethasone | en_GB |
dc.subject | fluticasone | en_GB |
dc.subject | inhaled corticosteroids | en_GB |
dc.subject | pneumonia | en_GB |
dc.title | Interclass Difference in Pneumonia Risk in COPD Patients Initiating Fixed Dose Inhaled Treatment Containing Extrafine Particle Beclometasone versus Fine Particle Fluticasone | en_GB |
dc.type | Article | en_GB |
dc.date.available | 2022-03-24T10:14:19Z | |
dc.identifier.issn | 1176-9106 | |
exeter.place-of-publication | New Zealand | |
dc.description | This is the final version. Available on open access from Dove Press via the DOI in this record | en_GB |
dc.identifier.eissn | 1178-2005 | |
dc.identifier.journal | International Journal of Chronic Obstructive Pulmonary Disease | en_GB |
dc.relation.ispartof | Int J Chron Obstruct Pulmon Dis, 17 | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc/3.0/ | en_GB |
dcterms.dateAccepted | 2022-01-24 | |
rioxxterms.version | VoR | en_GB |
rioxxterms.licenseref.startdate | 2022-02-15 | |
rioxxterms.type | Journal Article/Review | en_GB |
refterms.dateFCD | 2022-03-24T10:11:13Z | |
refterms.versionFCD | VoR | |
refterms.dateFOA | 2022-03-24T10:14:49Z | |
refterms.panel | A | en_GB |
refterms.dateFirstOnline | 2022-02-15 |
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Except where otherwise noted, this item's licence is described as ©2022 Price et al. This work is published and licensed by Dove Medical Press Limited. Open access. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution–Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).