An investigation of age-related differential item functioning in the EQ-5D-5L and SF-12v2 using item response theory
dc.contributor.author | Penton, H | |
dc.contributor.author | Dayson, C | |
dc.contributor.author | Hulme, C | |
dc.contributor.author | Young, T | |
dc.date.accessioned | 2022-03-24T10:27:03Z | |
dc.date.issued | 2022-04-27 | |
dc.date.updated | 2022-03-24T09:28:17Z | |
dc.description.abstract | Objective: In economic evaluations, quality of life is measured using patient reported outcome measures (PROMs), such as the EQ-5D-5L. A key assumption for the validity of PROMs data is measurement invariance, which requires that PROM items and response options are interpreted the same across respondents. If measurement invariance is violated, PROMs exhibit differential item functioning (DIF), whereby individuals from different groups with the same underlying health respond differently, potentially biasing scores. One important group of healthcare consumers who have been shown to have different views or priorities over health is older adults. This study investigates age-related DIF in the EQ-5D-5L using item response theory (IRT) and ordinal logistic regression (OLR) approaches. Methods: Multiple group IRT models were used to investigate DIF, by assessing whether older adults aged 65+ and younger adults aged 18-64 with the same underlying health had different IRT parameter estimates and expected item and EQ-5D-5L level sum scores (LSSs). OLR was also used to examine whether DIF resulted in meaningful differences in expected EQ-LSSs. Effect sizes examined whether DIF indicated meaningful score differences. Results: The anxiety/depression item exhibited meaningful DIF in both approaches, with older adults less likely to report problems. Pain/discomfort and mobility exhibited DIF to a lesser extent. Conclusion: When using the EQ-5D-5L to evaluate interventions and make resource allocation decisions, scoring bias due to DIF should be controlled for to prevent inefficient service provision, where the most cost-effective services are not provided, which could be detrimental to patients and the efficiency of health budgets. | en_GB |
dc.description.sponsorship | National Institute for Health Research (NIHR) | en_GB |
dc.identifier.citation | Published online 27 April 2022 | en_GB |
dc.identifier.doi | 10.1016/j.jval.2022.03.009 | |
dc.identifier.uri | http://hdl.handle.net/10871/129143 | |
dc.identifier | ORCID: 0000-0003-2077-0419 (Hulme, Claire) | |
dc.language.iso | en | en_GB |
dc.publisher | Elsevier / International Society for Pharmacoeconomics and Outcomes Research | en_GB |
dc.rights | © 2022, International Society for Pharmacoeconomics and Outcomes Research, Inc. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). | en_GB |
dc.subject | Differential item functioning | en_GB |
dc.subject | response heterogeneity | en_GB |
dc.subject | item response theory | en_GB |
dc.subject | ordinal logistic regression | en_GB |
dc.subject | PROMs | en_GB |
dc.subject | quality of life | en_GB |
dc.subject | EQ-5D | en_GB |
dc.title | An investigation of age-related differential item functioning in the EQ-5D-5L and SF-12v2 using item response theory | en_GB |
dc.type | Article | en_GB |
dc.date.available | 2022-03-24T10:27:03Z | |
dc.identifier.issn | 1524-4733 | |
dc.description | This is the final version. Available on open access from Elsevier via the DOI in this record | en_GB |
dc.identifier.journal | Value in Health | en_GB |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | en_GB |
dcterms.dateAccepted | 2022-03-19 | |
rioxxterms.version | VoR | en_GB |
rioxxterms.licenseref.startdate | 2022-03-19 | |
rioxxterms.type | Journal Article/Review | en_GB |
refterms.dateFCD | 2022-03-24T09:28:20Z | |
refterms.versionFCD | AM | |
refterms.dateFOA | 2022-05-05T14:31:05Z | |
refterms.panel | A | en_GB |
Files in this item
This item appears in the following Collection(s)
Except where otherwise noted, this item's licence is described as © 2022, International Society for Pharmacoeconomics and Outcomes Research, Inc. Published by Elsevier Inc. This is an open access article
under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).