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Relevance of sleep and associated structural changes in GBA1 mouse to human rapid eye movement behavior disorder.

dc.contributor.authorGelegen, C
dc.contributor.authorCash, D
dc.contributor.authorIlic, K
dc.contributor.authorSander, M
dc.contributor.authorKim, E
dc.contributor.authorSimmons, C
dc.contributor.authorBernanos, M
dc.contributor.authorLama, J
dc.contributor.authorRandall, K
dc.contributor.authorBrown, JT
dc.contributor.authorKalanj-Bognar, S
dc.contributor.authorCooke, S
dc.contributor.authorRay Chaudhuri, K
dc.contributor.authorBallard, C
dc.contributor.authorFrancis, P
dc.contributor.authorRosenzweig, I
dc.date.accessioned2022-05-19T11:00:46Z
dc.date.issued2022-05-13
dc.date.updated2022-05-19T10:41:53Z
dc.description.abstractRapid eye movement (REM) sleep behaviour disorder (RBD) is a REM parasomnia that often predicts the later occurrence of alpha-synucleinopathies. Variants in the gene encoding for the lysosomal enzyme glucocerebrosidase, GBA, strongly increase the risk of RBD. In a GBA1-mouse model recently shown to mimic prodromal stages of α-synucleinopathy, we now demonstrate striking REM and NREM electroencephalographic sleep abnormalities accompanied by distinct structural changes in the more widespread sleep neurocircuitry.en_GB
dc.description.sponsorshipWellcome Trusten_GB
dc.description.sponsorshipWellcome Trusten_GB
dc.description.sponsorshipCroatian Science Foundationen_GB
dc.format.extent7973-
dc.identifier.citationVol. 12, article 7973en_GB
dc.identifier.doihttps://doi.org/10.1038/s41598-022-11516-x
dc.identifier.grantnumber103952/Z/14/Zen_GB
dc.identifier.grantnumber212934/Z/18/Zen_GB
dc.identifier.grantnumberIP-2016-06-8636en_GB
dc.identifier.urihttp://hdl.handle.net/10871/129684
dc.identifierORCID: 0000-0001-5269-7661 (Brown, Jonathan T)
dc.identifierScopusID: 56169451300 (Brown, Jonathan T)
dc.language.isoenen_GB
dc.publisherNature Researchen_GB
dc.relation.urlhttps://www.ncbi.nlm.nih.gov/pubmed/35562385en_GB
dc.rights© The Author(s) 2022. Open Access Tis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. Te images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.en_GB
dc.subjectAnimalsen_GB
dc.subjectHumansen_GB
dc.subjectMiceen_GB
dc.subjectProdromal Symptomsen_GB
dc.subjectREM Sleep Behavior Disorderen_GB
dc.subjectSleepen_GB
dc.subjectSleep, REMen_GB
dc.subjectSynucleinopathiesen_GB
dc.titleRelevance of sleep and associated structural changes in GBA1 mouse to human rapid eye movement behavior disorder.en_GB
dc.typeArticleen_GB
dc.date.available2022-05-19T11:00:46Z
dc.identifier.issn2045-2322
exeter.article-number7973
exeter.place-of-publicationEngland
dc.descriptionThis is the final version. Available from Nature Research via the DOI in this record. en_GB
dc.descriptionData availability: All data that support the findings of this study are available upon reasonable request from the corresponding author.en_GB
dc.identifier.journalScientific Reportsen_GB
dc.relation.ispartofSci Rep, 12(1)
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_GB
dcterms.dateAccepted2022-04-22
rioxxterms.versionVoRen_GB
rioxxterms.licenseref.startdate2022-05-13
rioxxterms.typeJournal Article/Reviewen_GB
refterms.dateFCD2022-05-19T10:57:41Z
refterms.versionFCDVoR
refterms.dateFOA2022-05-19T11:01:12Z
refterms.panelAen_GB
refterms.dateFirstOnline2022-05-13


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© The Author(s) 2022. Open Access Tis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. Te images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
Except where otherwise noted, this item's licence is described as © The Author(s) 2022. Open Access Tis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. Te images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.