Are synthetic glucocorticoids in the aquatic environment a risk to fish?
dc.contributor.author | Hamilton, CM | |
dc.contributor.author | Winter, MJ | |
dc.contributor.author | Margiotta-Casaluci, L | |
dc.contributor.author | Owen, SF | |
dc.contributor.author | Tyler, CR | |
dc.date.accessioned | 2022-05-25T09:06:58Z | |
dc.date.issued | 2022-02-28 | |
dc.date.updated | 2022-05-24T15:12:11Z | |
dc.description.abstract | The glucocorticosteroid, or glucocorticoid (GC), system is largely conserved across vertebrates and plays a central role in numerous vital physiological processes including bone development, immunomodulation, and modification of glucose metabolism and the induction of stress-related behaviours. As a result of their wide-ranging actions, synthetic GCs are widely prescribed for numerous human and veterinary therapeutic purposes and consequently have been detected extensively within the aquatic environment. Synthetic GCs designed for humans are pharmacologically active in non-mammalian vertebrates, including fish, however they are generally detected in surface waters at low (ng/L) concentrations. In this review, we assess the potential environmental risk of synthetic GCs to fish by comparing available experimental data and effect levels in fish with those in mammals. We found the majority of compounds were predicted to have insignificant risk to fish, however some compounds were predicted to be of moderate and high risk to fish, although the dataset of compounds used for this analysis was small. Given the common mode of action and high level of inter-species target conservation exhibited amongst the GCs, we also give due consideration to the potential for mixture effects, which may be particularly significant when considering the potential for environmental impact from this class of pharmaceuticals. Finally, we also provide recommendations for further research to more fully understand the potential environmental impact of this relatively understudied group of commonly prescribed human and veterinary drugs. | en_GB |
dc.description.sponsorship | Biotechnology and Biological Sciences Research Council/AstraZeneca | en_GB |
dc.description.sponsorship | Biotechnology and Biological Sciences Research Council | en_GB |
dc.description.sponsorship | University of Exeter | en_GB |
dc.format.extent | 107163- | |
dc.format.medium | Print-Electronic | |
dc.identifier.citation | Vol. 162, article 107163 | en_GB |
dc.identifier.doi | https://doi.org/10.1016/j.envint.2022.107163 | |
dc.identifier.grantnumber | BB/R505353/1 | en_GB |
dc.identifier.grantnumber | (BB/P025528 | en_GB |
dc.identifier.uri | http://hdl.handle.net/10871/129722 | |
dc.identifier | ORCID: 0000-0002-1196-0483 (Winter, Matthew J) | |
dc.identifier | ScopusID: 7202444342 (Winter, Matthew J) | |
dc.identifier | ORCID: 0000-0003-2353-5748 (Tyler, Charles R) | |
dc.language.iso | en | en_GB |
dc.publisher | Elsevier | en_GB |
dc.relation.url | https://www.ncbi.nlm.nih.gov/pubmed/35240385 | en_GB |
dc.rights | © 2022 Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). | en_GB |
dc.subject | Ecotoxicology | en_GB |
dc.subject | Fish | en_GB |
dc.subject | Glucocorticoids | en_GB |
dc.subject | Pharmaceuticals | en_GB |
dc.subject | Read-across | en_GB |
dc.title | Are synthetic glucocorticoids in the aquatic environment a risk to fish? | en_GB |
dc.type | Article | en_GB |
dc.date.available | 2022-05-25T09:06:58Z | |
dc.identifier.issn | 0160-4120 | |
exeter.article-number | 107163 | |
exeter.place-of-publication | Netherlands | |
dc.description | This is the final version. Available from Elsevier via the DOI in this record. | en_GB |
dc.identifier.journal | Environment International | en_GB |
dc.relation.ispartof | Environ Int, 162 | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | en_GB |
dcterms.dateAccepted | 2022-02-22 | |
rioxxterms.version | VoR | en_GB |
rioxxterms.licenseref.startdate | 2022-02-28 | |
rioxxterms.type | Journal Article/Review | en_GB |
refterms.dateFCD | 2022-05-25T09:02:46Z | |
refterms.versionFCD | VoR | |
refterms.dateFOA | 2022-05-25T09:07:01Z | |
refterms.panel | A | en_GB |
refterms.dateFirstOnline | 2022-02-28 |
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Except where otherwise noted, this item's licence is described as © 2022 Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).