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dc.contributor.authorTakesono, A
dc.contributor.authorSchirrmacher, P
dc.contributor.authorScott, A
dc.contributor.authorGreen, JM
dc.contributor.authorLee, O
dc.contributor.authorWinter, MJ
dc.contributor.authorKudoh, T
dc.contributor.authorTyler, CR
dc.date.accessioned2022-05-25T09:18:46Z
dc.date.issued2022-01-13
dc.date.updated2022-05-24T15:13:32Z
dc.description.abstractEstrogens are well-known to regulate development of sexual dimorphism of the brain; however, their role in embryonic brain development prior to sex-differentiation is unclear. Using estrogen biosensor zebrafish models, we found that estrogen activity in the embryonic brain occurs from early neurogenesis specifically in a type of glia in the olfactory bulb (OB), which we name estrogen-responsive olfactory bulb (EROB) cells. In response to estrogen, EROB cells overlay the outermost layer of the OB and interact tightly with olfactory sensory neurons at the olfactory glomeruli. Inhibiting estrogen activity using an estrogen receptor antagonist, ICI182,780 (ICI), and/or EROB cell ablation impedes olfactory glomerular development, including the topological organisation of olfactory glomeruli and inhibitory synaptogenesis in the OB. Furthermore, activation of estrogen signalling inhibits both intrinsic and olfaction-dependent neuronal activity in the OB, whereas ICI or EROB cell ablation results in the opposite effect on neuronal excitability. Altering the estrogen signalling disrupts olfaction-mediated behaviour in later larval stage. We propose that estrogens act on glia to regulate development of OB circuits, thereby modulating the local excitability in the OB and olfaction-mediated behaviour.en_GB
dc.description.sponsorshipBiotechnology and Biological Sciences Research Councilen_GB
dc.description.sponsorshipBiotechnology and Biological Sciences Research Councilen_GB
dc.description.sponsorshipUniversity of Exeteren_GB
dc.format.extentdev199860-
dc.format.mediumPrint-Electronic
dc.identifier.citationVol. 149, No.1, article dev199860en_GB
dc.identifier.doihttps://doi.org/10.1242/dev.199860
dc.identifier.grantnumberBB/L020637/1en_GB
dc.identifier.grantnumberBB/P025528/1en_GB
dc.identifier.urihttp://hdl.handle.net/10871/129723
dc.identifierORCID: 0000-0002-1196-0483 (Winter, Matthew J)
dc.identifierScopusID: 7202444342 (Winter, Matthew J)
dc.identifierORCID: 0000-0002-5373-2737 (Kudoh, Tetsuhiro)
dc.identifierORCID: 0000-0003-2353-5748 (Tyler, Charles R)
dc.language.isoenen_GB
dc.publisherThe Company of Biologistsen_GB
dc.relation.urlhttps://www.ncbi.nlm.nih.gov/pubmed/35023540en_GB
dc.rights© 2022. Published by The Company of Biologists Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.en_GB
dc.subjectEmbryogenesisen_GB
dc.subjectEndocrine disrupting chemicalsen_GB
dc.subjectOlfactory glomerular developmenten_GB
dc.subjectOlfactory-mediated behaviouren_GB
dc.subjectRadial glia progenitor cellsen_GB
dc.subjectTransgenic zebrafish embryoen_GB
dc.titleEstrogens regulate early embryonic development of the olfactory sensory system via estrogen-responsive glia.en_GB
dc.typeArticleen_GB
dc.date.available2022-05-25T09:18:46Z
dc.identifier.issn0950-1991
exeter.article-numberARTN dev199860
exeter.place-of-publicationEngland
dc.descriptionThis is the final version. Available from The Company of Biologists via the DOI in this record. en_GB
dc.identifier.eissn1477-9129
dc.identifier.journalDevelopmenten_GB
dc.relation.ispartofDevelopment, 149(1)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0en_GB
dcterms.dateAccepted2021-12-02
dc.rights.licenseCC BY
rioxxterms.versionVoRen_GB
rioxxterms.licenseref.startdate2022-01-13
rioxxterms.typeJournal Article/Reviewen_GB
refterms.dateFCD2022-05-25T09:13:02Z
refterms.versionFCDVoR
refterms.dateFOA2022-05-25T09:18:49Z
refterms.panelAen_GB
refterms.dateFirstOnline2022-01-13


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© 2022. Published by The Company of Biologists Ltd. 
This is an Open Access article distributed under the terms of the Creative Commons Attribution
License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use,
distribution and reproduction in any medium provided that the original work is properly attributed.
Except where otherwise noted, this item's licence is described as © 2022. Published by The Company of Biologists Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.