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Genetics of early-life head circumference and genetic correlations with neurological, psychiatric and cognitive outcomes

dc.contributor.authorVogelezang, S
dc.contributor.authorBradfield, JP
dc.contributor.authorVogelezang, S
dc.contributor.authorBradfield, JP
dc.contributor.authorJohansson, S
dc.contributor.authorStergiakouli, E
dc.contributor.authorThiering, E
dc.contributor.authorPennell, CE
dc.contributor.authorAhluwalia, TS
dc.contributor.authorKarhunen, V
dc.contributor.authorScholz, M
dc.contributor.authorLiu, X
dc.contributor.authorIñiguez, C
dc.contributor.authorRaitakari, OT
dc.contributor.authorBacelis, J
dc.contributor.authorSchnurr, TM
dc.contributor.authorLakka, TA
dc.contributor.authorNtalla, I
dc.contributor.authorLind, MV
dc.contributor.authorLauritzen, L
dc.contributor.authorHerrala, S
dc.contributor.authorLin, FTJ
dc.contributor.authorFrithioff-Bøjsøe, C
dc.contributor.authorBeaumont, RN
dc.contributor.authorZafarmand, MH
dc.contributor.authorRzehak, P
dc.contributor.authorBilbao, JR
dc.contributor.authorJunna, N
dc.contributor.authorVonk, JM
dc.contributor.authorRifas-Shiman, SL
dc.contributor.authorJanjanam, VD
dc.contributor.authorKnol, MJ
dc.contributor.authorRamdas, S
dc.contributor.authorBeilin, L
dc.contributor.authorBønnelykke, K
dc.contributor.authorCasas, M
dc.contributor.authorEriksson, JG
dc.contributor.authorEscribano, J
dc.contributor.authorEvans, TE
dc.contributor.authorGehring, U
dc.contributor.authorGeller, F
dc.contributor.authorGrote, V
dc.contributor.authorGruszfeld, D
dc.contributor.authorHakonarson, H
dc.contributor.authorHattersley, AT
dc.contributor.authorHave, CT
dc.contributor.authorGeoffrey Hayes, M
dc.contributor.authorHeinrich, J
dc.contributor.authorHelgeland, Ø
dc.contributor.authorHolloway, J
dc.contributor.authorJoro, R
dc.contributor.authorJuodakis, J
dc.contributor.authorKnight, BA
dc.contributor.authorKoletzko, B
dc.contributor.authorKörner, A
dc.contributor.authorLanghendries, J-P
dc.contributor.authorLeinonen, JT
dc.contributor.authorLindi, V
dc.contributor.authorLund, MAV
dc.contributor.authorLye, S
dc.contributor.authorMelbye, M
dc.contributor.authorMichaelsen, KF
dc.contributor.authorMorgen, CS
dc.contributor.authorNiinikoski, H
dc.contributor.authorPahkala, K
dc.contributor.authorPanoutsopoulou, K
dc.contributor.authorPedersen, O
dc.contributor.authorRivadeneira, F
dc.contributor.authorSanta-Marina, L
dc.contributor.authorSchaik, BDC
dc.contributor.authorScholtens, D
dc.contributor.authorSebert, S
dc.contributor.authorTamayo, I
dc.contributor.authorTimpson, NJ
dc.contributor.authorTorrent, M
dc.contributor.authorUitterlinden, AG
dc.contributor.authorVaudel, M
dc.contributor.authorVerduci, E
dc.contributor.authorVinding, R
dc.contributor.authorVogel, M
dc.contributor.authorZeggini, E
dc.contributor.authorBrown, C
dc.contributor.authorAdams, HHH
dc.contributor.authorKarmaus, W
dc.contributor.authorHivert, M-F
dc.contributor.authorKoppelman, GH
dc.contributor.authorWidén, E
dc.contributor.authorFernandez-Jimenez, N
dc.contributor.authorWaldenberger, M
dc.contributor.authorVrijkotte, TGM
dc.contributor.authorFreathy, RM
dc.contributor.authorHolm, J-C
dc.contributor.authorLowe, WL
dc.contributor.authorGrarup, N
dc.contributor.authorHansen, T
dc.contributor.authorDedoussis, GV
dc.contributor.authorAtalay, M
dc.contributor.authorNohr, EA
dc.contributor.authorJacobsson, B
dc.contributor.authorPitkänen, N
dc.contributor.authorVrijheid, M
dc.contributor.authorFeenstra, B
dc.contributor.authorKiess, W
dc.contributor.authorJarvelin, M-R
dc.contributor.authorBisgaard, H
dc.contributor.authorWang C, C
dc.contributor.authorStandl, M
dc.contributor.authorMcCarthy, MI
dc.contributor.authorPourcain, BS
dc.contributor.authorNjølstad, PR
dc.contributor.authorGrant, SFA
dc.contributor.authorFelix, JF
dc.contributor.authorJaddoe, VWV
dc.date.accessioned2022-06-08T11:02:30Z
dc.date.issued2022-06-04
dc.date.updated2022-06-08T10:15:49Z
dc.description.abstractAbstract Background: Head circumference is associated with intelligence and tracks from childhood into adulthood. Methods: We performed a genome-wide association study meta-analysis and follow-up of head circumference in a total of 29,192 participants between 6 and 30 months of age. Results: Seven loci reached genome-wide signifcance in the combined discovery and replication analysis of which three loci near ARFGEF2, MYCL1, and TOP1, were novel. We observed positive genetic correlations for early-life head circumference with adult intracranial volume, years of schooling, childhood and adult intelligence, but not with adult psychiatric, neurological, or personality-related phenotypes. Conclusions: The results of this study indicate that the biological processes underlying early-life head circumference overlap largely with those of adult head circumference. The associations of early-life head circumference with cognitive outcomes across the life course are partly explained by genetics.en_GB
dc.description.sponsorshipWellcome Trusten_GB
dc.description.sponsorshipSimons Foundationen_GB
dc.description.sponsorshipWellcome Trusten_GB
dc.description.sponsorshipMRC & WTen_GB
dc.description.sponsorshipUniversity of Southern Denmarken_GB
dc.description.sponsorshipMax Planck core societyen_GB
dc.identifier.citationVol. 15, article 124en_GB
dc.identifier.doihttps://doi.org/10.1186/s12920-022-01281-1
dc.identifier.grantnumber098051en_GB
dc.identifier.grantnumber514787en_GB
dc.identifier.grantnumber202802/Z/16/Zen_GB
dc.identifier.grantnumber102215/2/13/2en_GB
dc.identifier.urihttp://hdl.handle.net/10871/129879
dc.identifierORCID: 0000-0003-4152-2238 (Freathy, Rachel M)
dc.language.isoenen_GB
dc.publisherBMCen_GB
dc.relation.urlhttps://egg-consortium.org/en_GB
dc.rights© The Author(s) 2022. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativeco mmons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the dataen_GB
dc.subjectHead circumferenceen_GB
dc.subjectGenome-wide association studyen_GB
dc.subjectGenetic correlationsen_GB
dc.subjectInfancyen_GB
dc.titleGenetics of early-life head circumference and genetic correlations with neurological, psychiatric and cognitive outcomesen_GB
dc.typeArticleen_GB
dc.date.available2022-06-08T11:02:30Z
exeter.article-number124
dc.descriptionThis is the final version. Available from BMC via the DOI in this record. en_GB
dc.descriptionAvailability of data and materials GWAS summary data will be deposited at the EGG website (https://egg-consortium.org/) at publication. Individual study data are available from the corresponding author on reasonable request.en_GB
dc.identifier.eissn1755-8794
dc.identifier.journalBMC Medical Genomicsen_GB
dc.relation.ispartofBMC Medical Genomics, 15(1)
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_GB
dcterms.dateAccepted2022-05-30
rioxxterms.versionVoRen_GB
rioxxterms.licenseref.startdate2022-06-04
rioxxterms.typeJournal Article/Reviewen_GB
refterms.dateFCD2022-06-08T10:55:37Z
refterms.versionFCDVoR
refterms.dateFOA2022-06-08T11:02:40Z
refterms.panelAen_GB
refterms.dateFirstOnline2022-06-04


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© The Author(s) 2022. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativeco mmons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data
Except where otherwise noted, this item's licence is described as © The Author(s) 2022. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativeco mmons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data