Assessing ethnic inequalities in diagnostic interval of common cancers: A population-based UK cohort study
dc.contributor.author | Martins, T | |
dc.contributor.author | Abel, G | |
dc.contributor.author | Ukoumunne, OC | |
dc.contributor.author | Price, S | |
dc.contributor.author | Lyratzopoulos, G | |
dc.contributor.author | Chinegwundoh, F | |
dc.contributor.author | Hamilton, W | |
dc.date.accessioned | 2022-07-08T12:52:35Z | |
dc.date.issued | 2022-06-23 | |
dc.date.updated | 2022-07-08T12:20:52Z | |
dc.description.abstract | Background: This study investigated ethnic differences in diagnostic interval (DI)—the period between initial primary care presentation and diagnosis. Methods: We analysed the primary care-linked data of patients who reported features of seven cancers (breast, lung, prostate, colorectal, oesophagogastric, myeloma, and ovarian) one year before diagnosis. Accelerated failure time (AFT) models investigated the association between DI and ethnicity, adjusting for age, sex, deprivation, and morbidity. Results: Of 126,627 eligible participants, 92.1% were White, 1.99% Black, 1.71% Asian, 1.83% Mixed, and 2.36% were of Other ethnic backgrounds. Considering all cancer sites combined, the median (interquartile range) DI was 55 (20–175) days, longest in lung [127, (42–265) days], and shortest in breast cancer [13 (13, 8–18) days]. DI for the Black and Asian groups was 10% (AFT ratio, 95%CI 1.10, 1.05–1.14) and 16% (1.16, 1.10–1.22), respectively, longer than for the White group. Sitespecific analyses revealed evidence of longer DI in Asian and Black patients with prostate, colorectal, and oesophagogastric cancer, plus Black patients with breast cancer and myeloma, and the Mixed group with lung cancer compared with White patients. DI was shorter for the Other group with lung, prostate, myeloma, and oesophagogastric cancer than the White group. Conclusion: We found limited and inconsistent evidence of ethnic differences in DI among patients who reported cancer features in primary care before diagnosis. Our findings suggest that inequalities in diagnostic intervals, where present, are unlikely to be the sole explanation for ethnic variations in cancer outcomes | en_GB |
dc.description.sponsorship | Cancer Research UK | en_GB |
dc.description.sponsorship | Cancer Research UK | en_GB |
dc.description.sponsorship | National Institute for Health Research | en_GB |
dc.description.sponsorship | National Institute for Health Research | en_GB |
dc.identifier.citation | Vol. 14, No. 13, article 3085 | en_GB |
dc.identifier.doi | https://doi.org/10.3390/cancers14133085 | |
dc.identifier.grantnumber | C56361/A26124 | en_GB |
dc.identifier.grantnumber | C18081/A18180 | en_GB |
dc.identifier.grantnumber | PRU-1217-21601 | en_GB |
dc.identifier.uri | http://hdl.handle.net/10871/130196 | |
dc.identifier | ORCID: 0000-0001-5226-4073 (Martins, Tanimola) | |
dc.language.iso | en | en_GB |
dc.publisher | MDPI | en_GB |
dc.rights | © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). | en_GB |
dc.subject | primary care | en_GB |
dc.subject | diagnostic interval | en_GB |
dc.subject | ethnic inequalities | en_GB |
dc.subject | early detection | en_GB |
dc.subject | diagnostic pathway | en_GB |
dc.subject | symptomatic cancer | en_GB |
dc.title | Assessing ethnic inequalities in diagnostic interval of common cancers: A population-based UK cohort study | en_GB |
dc.type | Article | en_GB |
dc.date.available | 2022-07-08T12:52:35Z | |
dc.identifier.issn | 2072-6694 | |
dc.description | This is the final version. Available from MDPI via the DOI in this record. | en_GB |
dc.description | Data Availability Statement: This study used CPRD-linked data, access to which is subject to protocol approval by an Independent Scientific Advisory Committee, and under which conditions data cannot be shared directly | en_GB |
dc.identifier.journal | Cancers | en_GB |
dc.relation.ispartof | Cancers | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | en_GB |
dcterms.dateAccepted | 2022-06-20 | |
rioxxterms.version | VoR | en_GB |
rioxxterms.licenseref.startdate | 2022-06-20 | |
rioxxterms.type | Journal Article/Review | en_GB |
refterms.dateFCD | 2022-07-08T12:20:53Z | |
refterms.versionFCD | AM | |
refterms.dateFOA | 2022-07-08T12:52:41Z | |
refterms.panel | A | en_GB |
refterms.dateFirstOnline | 2022-06-23 |
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Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).