Clinical and Biomedical Sciences
Recent Submissions
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Raman spectroscopy of ovarian and peritoneal tissue in the assessment of ovarian cancer
(Royal Society of Chemistry (RSC), 27 February 2025)During post chemotherapy surgery for ovarian cancer, it is important to ensure that any residual disease is carefully assessed and removed. The assessment remains subjective, despite clear evidence of the benefits of ... -
Optimal exercise modalities and doses for therapeutic management of osteoarthritis of the knee
(Frontiers Media, 4 February 2025)Osteoarthritis (OA) is a progressive osteoarticular disease affecting the whole joint. In the United Kingdom, OA is the most prevalent joint disease, with knee osteoarthritis (KOA) being the most common type of OA. Key ... -
Treatment outcomes with oral anti‐hyperglycaemic therapies in people with diabetes secondary to a pancreatic condition (type 3c diabetes): A population‐based cohort study
(Wiley, 6 January 2025)Aims: To assess outcomes of oral anti-hyperglycaemic therapies in people with diabetes secondary to a pancreatic condition (type 3c), where specific treatment guidance is limited. Materials and Methods: Using hospital-linked ... -
A five-drug class model using routinely available clinical features to optimise prescribing in type 2 diabetes: a prediction model development and validation study
(Elsevier, 25 February 2025)Background: Data to support individualised choice of optimal glucose-lowering therapy are scarce for people with type 2 diabetes. We aimed to establish whether routinely available clinical features can be used to predict ... -
An axonal brake on striatal dopamine output by cholinergic interneurons
(Nature Research, 13 March 2025)Depolarization of axons is necessary for somatic action potentials to trigger axonal neurotransmitter release. Here we show that striatal cholinergic interneurons (ChIs) and nicotinic receptors (nAChRs) on mouse dopamine ...