Clinical and Biomedical Sciences
Recent Submissions
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Are the cardiovascular properties of GLP-1 receptor agonists differentially modulated by sulfonylureas? Insights from post-hoc analysis of EXSCEL.
(Elsevier, 25 April 2024)AIMS: To examine whether the cardiovascular effects of glucagon-like peptide-1 (GLP-1) receptor agonists are attenuated by concurrent sulfonylurea (SU) therapy in a post-hoc analysis of the Exenatide Study of Cardiovascular ... -
Regulation of STAT1 signalling in human pancreatic β-cells by the lysine deacetylase, HDAC6; a new therapeutic opportunity in type 1 diabetes?
(American Diabetes Association, 14 June 2024)Type 1 diabetes arises from the selective destruction of pancreatic β-cells by autoimmune mechanisms and intracellular pathways driven by Janus (JAK)-kinase mediated STAT isoforms (especially STAT1 & STAT2) are implicated ... -
Image analysis using the Fluorescence Imaging of Nuclear Staining (FINS) algorithm.
(Springer, 17 June 2024)Finding appropriate image analysis techniques for a particular purpose can be difficult. In the context of the analysis of immunocytochemistry images, where the key information lies in the number of nuclei containing ... -
Repurposing drugs for senotherapeutic effect: Potential senomorphic effects of female synthetic hormones
(MDPI, 15 March 2024)Repurposing previously approved drugs may fast track the route to the clinic for potential senotherapeutics and improves the inefficiency of the clinical drug development pipeline. We performed a repurposing screen of 240 ... -
Multi-ancestry genome-wide association study of major depression aids locus discovery, fine mapping, gene prioritization and causal inference.
(Nature Research, 4 January 2024)Most genome-wide association studies (GWAS) of major depression (MD) have been conducted in samples of European ancestry. Here we report a multi-ancestry GWAS of MD, adding data from 21 cohorts with 88,316 MD cases and ...