• Senescence, regulators of alternative splicing and effects of trametinib treatment in progeroid syndromes 

  Bramwell, LR; Harries, LW (Springer, 26 September 2023)

  Progeroid syndromes such as Hutchinson Gilford Progeroid syndrome (HGPS), Werner syndrome (WS) and Cockayne syndrome (CS), result in severely reduced lifespans and premature ageing. Normal senescent cells show splicing ...

• Search strategy: A systematic review of the prevalence of microsatellite instability/deficient DNA mismatch repair by tumour location in early vs later onset colorectal cancer 

  Ward, R; Chen, G; Cooke, M; et al. (University of Exeter, 25 August 2023)

• P2X7R influences tau aggregate burden in human tauopathies and shows distinct signalling in microglia and astrocytes 

  Beltran-Lobo, P; Hughes, MM; Troakes, C; et al. (Elsevier, 15 September 2023)

  The purinoceptor P2X7R is a promising therapeutic target for tauopathies, including Alzheimer's disease (AD). Pharmacological inhibition or genetic knockdown of P2X7R ameliorates cognitive deficits and reduces pathological ...

• Impact of chemogenetic activation of dorsal vagal complex astrocytes in mice on adaptive glucoregulatory responses 

  MacDonald, AJ; Pye, KR; Beall, C; et al. (Wiley / British Society for Neuroendocrinology, 9 June 2023)

  The dorsal vagal complex (DVC) regulates diverse aspects of physiology including food intake and blood glucose homeostasis. Astrocytes play an active role in regulating DVC function and, by extension, physiological parameters. ...

• Bringing precision medicine to the management of pregnancy in women with glucokinase-MODY: a study of diagnostic accuracy and feasibility of non-invasive prenatal testing. 

  Hughes, AE; Houghton, JAL; Bunce, B; et al. (Springer, 31 August 2023)

  AIMS/HYPOTHESIS: In pregnancies where the mother has glucokinase-MODY (GCK-MODY), fetal growth is determined by fetal genotype. When the fetus inherits a maternal pathogenic GCK variant, normal fetal growth is anticipated, ...

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