Clinical and Biomedical Sciences
Recent Submissions
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Tissue Resident and Infiltrating Immune Cells: Their Influence on the Demise of Beta Cells in Type 1 Diabetes
(MDPI, 19 March 2025)Type 1 diabetes (T1D) is an organ-specific autoimmune disease that results in the selective loss of pancreatic beta cells and an eventual deficit in insulin production to maintain glucose homeostasis. It is now increasingly ... -
Evaluating prediction of short-term tolerability of five type 2 diabetes drug classes using routine clinical features: UK population-based study
(Wiley, 16 May 2025)Aims A precision medicine approach in type 2 diabetes (T2D) needs to consider potential treatment risks alongside established benefits for glycaemic and cardiometabolic outcomes. Considering five major T2D drug classes, ... -
Setd1a loss-of-function disrupts epigenetic regulation of ribosomal genes via altered DNA methylation
(Oxford University Press, 2025)Background and Hypothesis SETD1A, a histone methyltransferase, is implicated in schizophrenia through rare loss-of-function mutations. While SETD1A regulates gene expression via histone H3K4 methylation, its influence on ... -
Framing systematic reviews commissioned by policymakers as a hermeneutic process: A methodological commentary
(SAGE Publications, 31 March 2025)Policymakers increasingly seek to use systematic reviews to inform policy decisions in a wide variety of policy areas. The use of rigorous methods for assessing the available evidence makes systematic reviews a key tool ... -
Raman spectroscopy of ovarian and peritoneal tissue in the assessment of ovarian cancer
(Royal Society of Chemistry (RSC), 27 February 2025)During post chemotherapy surgery for ovarian cancer, it is important to ensure that any residual disease is carefully assessed and removed. The assessment remains subjective, despite clear evidence of the benefits of ...