Complexity reduction and opportunities in the design, integration and intensification of biocatalytic processes for metabolite synthesis
dc.contributor.author | Wohlgemuth, R | |
dc.contributor.author | Littlechild, J | |
dc.date.accessioned | 2022-08-23T14:13:42Z | |
dc.date.issued | 2022-07-22 | |
dc.date.updated | 2022-07-29T23:37:10Z | |
dc.description.abstract | The biosynthesis of metabolites from available starting materials is becoming an ever important area due to the increasing demands within the life science research area. Access to metabolites is making essential contributions to analytical, diagnostic, therapeutic and different industrial applications. These molecules can be synthesized by the enzymes of biological systems under sustainable process conditions. The facile synthetic access to the metabolite and metabolite-like molecular space is of fundamental importance. The increasing knowledge within molecular biology, enzyme discovery and production together with their biochemical and structural properties offers excellent opportunities for using modular cell-free biocatalytic systems. This reduces the complexity of synthesizing metabolites using biological whole-cell approaches or by classical chemical synthesis. A systems biocatalysis approach can provide a wealth of optimized enzymes for the biosynthesis of already identified and new metabolite molecules. | en_GB |
dc.format.extent | 958606- | |
dc.identifier.citation | Vol. 10, article 958606 | en_GB |
dc.identifier.doi | https://doi.org/10.3389/fbioe.2022.958606 | |
dc.identifier.uri | http://hdl.handle.net/10871/130495 | |
dc.identifier | ORCID: 0000-0002-7649-3986 (Littlechild, Jennifer) | |
dc.language.iso | en | en_GB |
dc.publisher | Frontiers Media | en_GB |
dc.rights | © 2022 Wohlgemuth and Littlechild. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. | en_GB |
dc.subject | cell-free biocatalysis | en_GB |
dc.subject | enzyme development | en_GB |
dc.subject | enzyme function | en_GB |
dc.subject | reaction engineering | en_GB |
dc.subject | biocatalytic process design | en_GB |
dc.subject | metabolite synthesis | en_GB |
dc.subject | bioprocess navigation | en_GB |
dc.title | Complexity reduction and opportunities in the design, integration and intensification of biocatalytic processes for metabolite synthesis | en_GB |
dc.type | Article | en_GB |
dc.date.available | 2022-08-23T14:13:42Z | |
dc.identifier.issn | 2296-4185 | |
dc.description | This is the final version. Available on open access from Frontiers Media via the DOI in this record | en_GB |
dc.identifier.eissn | 2296-4185 | |
dc.identifier.journal | Frontiers in Bioengineering and Biotechnology | en_GB |
dc.relation.ispartof | Frontiers in Bioengineering and Biotechnology, 10 | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | en_GB |
dcterms.dateAccepted | 2022-06-28 | |
rioxxterms.version | VoR | en_GB |
rioxxterms.licenseref.startdate | 2022-07-22 | |
rioxxterms.type | Journal Article/Review | en_GB |
refterms.dateFCD | 2022-08-01T08:33:50Z | |
refterms.versionFCD | VoR | |
refterms.dateFOA | 2022-08-23T14:13:51Z | |
refterms.panel | A | en_GB |
refterms.dateFirstOnline | 2022-07-22 |
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Except where otherwise noted, this item's licence is described as © 2022 Wohlgemuth and Littlechild. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.