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An enduring in vitro wound healing phase recipient by bioactive glass-graphene oxide nanocomposites

dc.contributor.authorNandhakumar, M
dc.contributor.authorThangaian, DT
dc.contributor.authorSundaram, S
dc.contributor.authorRoy, A
dc.contributor.authorSubramanian, B
dc.date.accessioned2022-09-20T09:14:42Z
dc.date.issued2022-09-28
dc.date.updated2022-09-19T09:13:13Z
dc.description.abstractBioactive glass (BG) is an interesting topic in soft tissue engineering because of its biocompatibility and bonding potential to increase fibroblast cell proliferation, synthesis of growth factors, and stimulate granulation tissue development. The proposed BG with and without sodium (Na) was prepared using the sol-gel method for wound healing studies. The BG/graphene oxide (GO) and BG (Na-free)/GO nanocomposites were investigated against fibroblast L929 cells in vitro; the 45S5 BG nanocomposites exhibited desired cell viability (80%), cell proliferation (30%), cell migration (25%), metabolic activity, and wound contraction due to extracellular matrix (ECM) production and enhanced protein release by fibroblast cells. Additionally, the antioxidant assays for BG, BG (Na-free), GO, and BG/GO, BG (Na-free)/GO were evaluated for effective wound healing properties. The results showed decreased inflammation sites in the wound area, which was assessed by the (2,2-diphenyl-1picryl-hydrazyl-hydrate) (DPPH) assay with 80% radical scavenging activity, confirming their anti-inflammatory and improved wound healing properties.en_GB
dc.description.sponsorshipDBT-RA Program in Biotechnology and Life Sciencesen_GB
dc.identifier.citationVol. 12, article 16162en_GB
dc.identifier.doihttps://doi.org/10.1038/s41598-022-20575-z
dc.identifier.urihttp://hdl.handle.net/10871/130889
dc.identifierORCID: 0000-0002-2097-9442 (Roy, Anurag)
dc.language.isoenen_GB
dc.publisherNature Researchen_GB
dc.rights© The Author(s) 2022. Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
dc.titleAn enduring in vitro wound healing phase recipient by bioactive glass-graphene oxide nanocompositesen_GB
dc.typeArticleen_GB
dc.date.available2022-09-20T09:14:42Z
dc.identifier.issn2045-2322
exeter.article-number16162
dc.descriptionThis is the final version. Available on open access from Nature Research via the DOI in this recorden_GB
dc.descriptionData Availability Statement: All data generated or analyzed during this study are included in this published article (and its Supplementary Information files). Competing interests The authors declare no competing interest.en_GB
dc.identifier.journalScientific Reportsen_GB
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en_GB
dcterms.dateAccepted2022-09-15
dcterms.dateSubmitted2022-07-02
rioxxterms.versionVoRen_GB
rioxxterms.licenseref.startdate2022-09-15
rioxxterms.typeJournal Article/Reviewen_GB
refterms.dateFCD2022-09-19T09:13:16Z
refterms.versionFCDAM
refterms.dateFOA2022-10-06T14:31:39Z
refterms.panelBen_GB


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© The Author(s) 2022. Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
Except where otherwise noted, this item's licence is described as © The Author(s) 2022. Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.