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dc.contributor.authorBosze, B
dc.contributor.authorOno, Y
dc.contributor.authorMattes, B
dc.contributor.authorSinner, C
dc.contributor.authorGourain, V
dc.contributor.authorThumberger, T
dc.contributor.authorTlili, S
dc.contributor.authorWittbrodt, J
dc.contributor.authorSaunders, TE
dc.contributor.authorSträhle, U
dc.contributor.authorSchug, A
dc.contributor.authorScholpp, S
dc.date.accessioned2022-10-13T10:33:54Z
dc.date.issued2020-06-01
dc.date.updated2022-10-13T09:26:11Z
dc.description.abstractThe notochord defines the axial structure of all vertebrates during development. Notogenesis is a result of major cell reorganization in the mesoderm, the convergence and the extension of the axial cells. However, it is currently not fully understood how these processes act together in a coordinated way during notochord formation. The prechordal plate is an actively migrating cell population in the central mesoderm anterior to the trailing notochordal plate cells. We show that prechordal plate cells express Protocadherin 18a (Pcdh18a), a member of the cadherin superfamily. We find that Pcdh18a-mediated recycling of E-cadherin adhesion complexes transforms prechordal plate cells into a cohesive and fast migrating cell group. In turn, the prechordal plate cells subsequently instruct the trailing mesoderm. We simulated cell migration during early mesoderm formation using a lattice-based mathematical framework and predicted that the requirement for an anterior, local motile cell cluster could guide the intercalation and extension of the posterior, axial cells. Indeed, a grafting experiment validated the prediction and local Pcdh18a expression induced an ectopic prechordal plate-like cell group migrating towards the animal pole. Our findings indicate that the Pcdh18a is important for prechordal plate formation, which influences the trailing mesodermal cell sheet by orchestrating the morphogenesis of the notochord.en_GB
dc.format.extent463-480
dc.format.mediumPrint-Electronic
dc.identifier.citationVol. 154, pp. 463-480en_GB
dc.identifier.doihttps://doi.org/10.1007/s00418-020-01887-5
dc.identifier.urihttp://hdl.handle.net/10871/131248
dc.identifierORCID: 0000-0002-7257-0120 (Ono, Yosuke)
dc.identifierScopusID: 12041146800 (Ono, Yosuke)
dc.identifierORCID: 0000-0002-4903-9657 (Scholpp, Steffen)
dc.identifierScopusID: 6508312503 (Scholpp, Steffen)
dc.identifierResearcherID: E-4472-2018 | H-2060-2013 (Scholpp, Steffen)
dc.language.isoenen_GB
dc.publisherSpringeren_GB
dc.relation.urlhttps://www.ncbi.nlm.nih.gov/pubmed/32488346en_GB
dc.rights© The Author(s) 2020. Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/en_GB
dc.titlePcdh18a regulates endocytosis of E-cadherin during axial mesoderm development in zebrafishen_GB
dc.typeArticleen_GB
dc.date.available2022-10-13T10:33:54Z
dc.identifier.issn0948-6143
exeter.place-of-publicationGermany
dc.descriptionThis is the final version. Available on open access from Springer via the DOI in this recorden_GB
dc.identifier.eissn1432-119X
dc.identifier.journalHistochemistry and Cell Biologyen_GB
dc.relation.ispartofHistochem Cell Biol, 154(5)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en_GB
dcterms.dateAccepted2020-05-14
dc.rights.licenseCC BY
rioxxterms.versionVoRen_GB
rioxxterms.licenseref.startdate2020-06-01
rioxxterms.typeJournal Article/Reviewen_GB
refterms.dateFCD2022-10-13T10:31:51Z
refterms.versionFCDVoR
refterms.dateFOA2022-10-13T10:34:02Z
refterms.panelAen_GB
refterms.dateFirstOnline2020-06-01


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© The Author(s) 2020. Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/
Except where otherwise noted, this item's licence is described as © The Author(s) 2020. Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/