dc.contributor.author | Rijlaarsdam, J | |
dc.contributor.author | Cosin-Tomas, M | |
dc.contributor.author | Schellhas, L | |
dc.contributor.author | Abrishamcar, S | |
dc.contributor.author | Malmberg, A | |
dc.contributor.author | Neumann, A | |
dc.contributor.author | Felix, JF | |
dc.contributor.author | Sunyer, J | |
dc.contributor.author | Gutzkow, KB | |
dc.contributor.author | Grazuleviciene, R | |
dc.contributor.author | Wright, J | |
dc.contributor.author | Kampouri, M | |
dc.contributor.author | Zar, HJ | |
dc.contributor.author | Stein, DJ | |
dc.contributor.author | Heinonen, K | |
dc.contributor.author | Räikkönen, K | |
dc.contributor.author | Lahti, J | |
dc.contributor.author | Huels, A | |
dc.contributor.author | Caramaschi, D | |
dc.contributor.author | Alemany, S | |
dc.contributor.author | Cecil, CAM | |
dc.date.accessioned | 2022-10-26T11:58:04Z | |
dc.date.issued | 2022-11-16 | |
dc.date.updated | 2022-10-26T10:18:38Z | |
dc.description.abstract | The general psychopathology factor (GPF) has been proposed as a way to capture variance shared between psychiatric symptoms. Despite a growing body of evidence showing both genetic and environmental influences on GPF, the biological mechanisms underlying these influences remain unclear. In the current study, we conducted epigenome-wide meta-analyses to identify both probe- and region-level associations of DNA methylation (DNAm) with school-age general psychopathology in six cohorts from the Pregnancy And Childhood Epigenetics (PACE) Consortium. DNAm was examined both at birth (cord blood; prospective analysis) and during school-age (peripheral whole blood; cross-sectional analysis) in total samples of N=2,178 and N=2,190, respectively. At school-age, we identified one probe (cg11945228) located in the Bromodomain-containing protein 2 gene (BRD2) that negatively
associated with GPF (p=8.58×10–8). We also identified a significant differentially methylated
region (DMR) at school-age (p=1.63×10–8), implicating the SHC Adaptor Protein 4 (SHC4) gene and the EP300-interacting inhibitor of differentiation 1 (EID1) gene that have been previously implicated in multiple types of psychiatric disorders in adulthood, including obsessive compulsive disorder, schizophrenia, and major depressive disorder. In contrast, no prospective associations were identified with DNAm at birth. Taken together, results of this study revealed some evidence of an association between DNAm at school-age and GPF. Future research with larger samples is needed to further assess DNAm variation associated with GPF | en_GB |
dc.identifier.citation | Published online 16 November 2022 | en_GB |
dc.identifier.doi | 10.1038/s41380-022-01871-6 | |
dc.identifier.uri | http://hdl.handle.net/10871/131443 | |
dc.language.iso | en | en_GB |
dc.publisher | Springer Nature | en_GB |
dc.rights.embargoreason | Under embargo until 16 May 2023 in compliance with publisher policy | en_GB |
dc.rights | © The Author(s), under exclusive licence to Springer Nature Limited 2022 | |
dc.title | DNA methylation and general psychopathology in childhood: An epigenome-wide meta-analysis from the PACE consortium | en_GB |
dc.type | Article | en_GB |
dc.date.available | 2022-10-26T11:58:04Z | |
dc.identifier.issn | 1359-4184 | |
dc.description | This is the author accepted manuscript. The final version is available from Springer Nature via the DOI in this record | en_GB |
dc.description | Data availability: Site-level meta-analytical results will be made publicly available upon acceptance for publication. For access to cohort-level data, requests can be sent directly to individual studies.
Code availability: Analytical codes can be requested from authors. | en_GB |
dc.identifier.eissn | 1476-5578 | |
dc.identifier.journal | Molecular Psychiatry | en_GB |
dc.rights.uri | http://www.rioxx.net/licenses/all-rights-reserved | en_GB |
dcterms.dateAccepted | 2022-10-25 | |
dcterms.dateSubmitted | 2022-06-06 | |
rioxxterms.version | AM | en_GB |
rioxxterms.licenseref.startdate | 2022-10-25 | |
rioxxterms.type | Journal Article/Review | en_GB |
refterms.dateFCD | 2022-10-26T10:18:41Z | |
refterms.versionFCD | AM | |
refterms.panel | A | en_GB |