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dc.contributor.authorWadey, CA
dc.contributor.authorBarker, AR
dc.contributor.authorStuart, G
dc.contributor.authorTran, DL
dc.contributor.authorLaohachai, K
dc.contributor.authorAyer, J
dc.contributor.authorCordina, R
dc.contributor.authorWilliams, CA
dc.date.accessioned2023-01-12T13:23:07Z
dc.date.issued2022-12-14
dc.date.updated2023-01-12T12:07:13Z
dc.description.abstractBACKGROUND: Peak oxygen consumption (peak ̇ VO2) is traditionally divided (“ratio- scaled”) by body mass (BM) for clinical interpretation. Yet, it is unknown whether ratio- scaling to BM can produce a valid size- independent expression of peak VO2 in people with a Fontan circulation. Furthermore, people with a Fontan circulation have deficits in lean mass, and it is unexplored whether using different measures of body composition may improve scaling validity. The objective was to assess the validity of different scaling denominators (BM, stature, body surface area, fat- free mass, lean mass, and appendicular lean mass using ratio and allometric scaling). ̇ METHODS AND RESULTS: Eighty- nine participants (age: 23.3±6.7 years; 53% female) with a Fontan circulation had their cardiorespiratory fitness and body composition measured by cardiopulmonary exercise testing and dual- energy x- ray absorptiometry. Ratio and allometric (log- linear regression) scaling was performed and Pearson correlations assessed scaling validity. Scaling denominators BM (r=−0.25, P=0.02), stature (r=0.46, P<0.001), and body surface area (0.23, P=0.03) were significantly correlated with their respective ratio- scaled expressions of peak ̇ VO2, but fat- free mass, lean mass, or appendicular Downloaded from http://ahajournals.org by on December 14, 2022 lean mass were not (r≤0.11; R2=1%). Allometrically expressed peak denominator (r=≤0.23; R2=≤4%). ̇ ̇ VO2 resulted in no significant correlation with any scaling CONCLUSIONS: The traditional and accepted method of ratio- scaling to BM is invalid because it fails to create a size- independent expression of peak VO2 in people with a Fontan circulation. However, ratio- scaling to measures of body composition (fat- free mass, lean mass, and appendicular lean mass) and allometric techniques can produce size- independent expressions of peak ̇ VO2 in people with a Fontan circulation.en_GB
dc.description.sponsorshipCanon Medical Systems UK Ltd.en_GB
dc.description.sponsorshipUniversity of Exeteren_GB
dc.description.sponsorshipMedical Research Future Funden_GB
dc.format.extente026181-
dc.format.mediumPrint-Electronic
dc.identifier.citationVol. 11(24), article e026181en_GB
dc.identifier.doihttps://doi.org/10.1161/JAHA.122.026181
dc.identifier.grantnumberARGCHDG000016en_GB
dc.identifier.urihttp://hdl.handle.net/10871/132224
dc.identifierORCID: 0000-0003-3275-7975 (Wadey, Curtis A)
dc.identifierORCID: 0000-0001-8610-5417 (Barker, Alan R)
dc.identifierScopusID: 14008425100 | 57369449900 (Barker, Alan R)
dc.identifierResearcherID: AAF-7777-2020 (Barker, Alan R)
dc.identifierORCID: 0000-0002-1740-6248 (Williams, Craig A)
dc.identifierScopusID: 57201609242 (Williams, Craig A)
dc.identifierResearcherID: AAQ-8954-2020 (Williams, Craig A)
dc.language.isoenen_GB
dc.publisherWiley / American Heart Associationen_GB
dc.relation.urlhttps://www.ncbi.nlm.nih.gov/pubmed/36515232en_GB
dc.rights© 2022 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.en_GB
dc.subjectCPETen_GB
dc.subjectallometryen_GB
dc.subjectcardiorespiratory fitnessen_GB
dc.subjectcongenital heart diseaseen_GB
dc.titleScaling Peak Oxygen Consumption for Body Size and Composition in People With a Fontan Circulationen_GB
dc.typeArticleen_GB
dc.date.available2023-01-12T13:23:07Z
dc.identifier.issn2047-9980
exeter.place-of-publicationEngland
dc.descriptionThis is the final version. Available on open access from Wiley via the DOI in this recorden_GB
dc.identifier.eissn2047-9980
dc.identifier.journalJournal of the American Heart Associationen_GB
dc.relation.ispartofJ Am Heart Assoc, 11(24)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en_GB
dcterms.dateAccepted2022-10-31
rioxxterms.versionVoRen_GB
rioxxterms.licenseref.startdate2022-12-14
rioxxterms.typeJournal Article/Reviewen_GB
refterms.dateFCD2023-01-12T13:19:46Z
refterms.versionFCDVoR
refterms.dateFOA2023-01-12T13:23:15Z
refterms.panelAen_GB


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© 2022 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Except where otherwise noted, this item's licence is described as © 2022 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.