dc.contributor.author | Manaia, CM | |
dc.contributor.author | Aga, DS | |
dc.contributor.author | Cytryn, E | |
dc.contributor.author | Gaze, WH | |
dc.contributor.author | Graham, DW | |
dc.contributor.author | Guo, J | |
dc.contributor.author | Leonard, AFC | |
dc.contributor.author | Li, L | |
dc.contributor.author | Murray, AK | |
dc.contributor.author | Nunes, OC | |
dc.contributor.author | Rodriguez-Mozaz, S | |
dc.contributor.author | Topp, E | |
dc.contributor.author | Zhang, T | |
dc.date.accessioned | 2023-03-03T12:51:24Z | |
dc.date.issued | 2022-12-29 | |
dc.date.updated | 2023-03-03T10:58:02Z | |
dc.description.abstract | Antibiotic-resistant bacteria (ARB) and antibiotic resistance genes (ARGs) are important environmental contaminants. Nonetheless, what drives the evolution, spread, and transmission of antibiotic resistance dissemination is still poorly understood. The abundance of ARB and ARGs is often elevated in human-impacted areas, especially in environments receiving fecal wastes, or in the presence of complex mixtures of chemical contaminants, such as pharmaceuticals and personal care products. Self-replication, mutation, horizontal gene transfer, and adaptation to different environmental conditions contribute to the persistence and proliferation of ARB in habitats under strong anthropogenic influence. Our review discusses the interplay between chemical contaminants and ARB and their respective genes, specifically in reference to co-occurrence, potential biostimulation, and selective pressure effects, and gives an overview of mitigation by existing man-made and natural barriers. Evidence and strategies to improve the assessment of human health risks due to environmental antibiotic resistance are also discussed. | en_GB |
dc.description.sponsorship | Portuguese Foundation for Science and Technology (FCT) | en_GB |
dc.description.sponsorship | European Union's Horizon 202 | en_GB |
dc.description.sponsorship | Australian Research Council | en_GB |
dc.description.sponsorship | Australian Research Council | en_GB |
dc.description.sponsorship | Natural Environment Research Council | en_GB |
dc.description.sponsorship | FCT/Ministry of Science, Technology, and Higher Education | en_GB |
dc.description.sponsorship | FCT/Ministry of Science, Technology, and Higher Education | en_GB |
dc.description.sponsorship | FCT/Ministry of Science, Technology, and Higher Education | en_GB |
dc.format.medium | Print-Electronic | |
dc.identifier.citation | Published online 29 December 2022 | en_GB |
dc.identifier.doi | https://doi.org/10.1002/etc.5555 | |
dc.identifier.grantnumber | UIDB/50016/2020 | en_GB |
dc.identifier.grantnumber | 1822 | en_GB |
dc.identifier.grantnumber | DP220101526 | en_GB |
dc.identifier.grantnumber | FT170100196 | en_GB |
dc.identifier.grantnumber | NE/V019279/1 | en_GB |
dc.identifier.grantnumber | UIDP/00511/2020 | en_GB |
dc.identifier.grantnumber | DP220101526 | en_GB |
dc.identifier.grantnumber | FT170100196 | en_GB |
dc.identifier.uri | http://hdl.handle.net/10871/132600 | |
dc.identifier | ORCID: 0000-0002-9345-6204 (Gaze, William H) | |
dc.identifier | ORCID: 0000-0002-8231-602X (Leonard, Anne FC) | |
dc.identifier | ORCID: 0000-0002-1388-754X (Murray, Aimee K) | |
dc.language.iso | en | en_GB |
dc.publisher | Wiley | en_GB |
dc.relation.url | https://www.ncbi.nlm.nih.gov/pubmed/36582150 | en_GB |
dc.rights | © 2022 SETAC | en_GB |
dc.subject | Wastewater | en_GB |
dc.subject | environmental contaminants | en_GB |
dc.subject | horizontal gene transfer | en_GB |
dc.subject | risk assessment | en_GB |
dc.title | The complex interplay between antibiotic resistance and pharmaceutical and personal care products in the environment. | en_GB |
dc.type | Article | en_GB |
dc.date.available | 2023-03-03T12:51:24Z | |
dc.identifier.issn | 0730-7268 | |
exeter.place-of-publication | United States | |
dc.description | This is the final version. Available from Wiley via the DOI in this record. | en_GB |
dc.identifier.eissn | 1552-8618 | |
dc.identifier.journal | Environmental Toxicology and Chemistry | en_GB |
dc.relation.ispartof | Environ Toxicol Chem | |
dc.rights.uri | http://www.rioxx.net/licenses/all-rights-reserved | en_GB |
dcterms.dateAccepted | 2022-12-20 | |
rioxxterms.version | VoR | en_GB |
rioxxterms.licenseref.startdate | 2022-12-29 | |
rioxxterms.type | Journal Article/Review | en_GB |
refterms.dateFCD | 2023-03-03T11:57:42Z | |
refterms.versionFCD | VoR | |
refterms.dateFOA | 2023-03-03T12:52:08Z | |
refterms.panel | A | en_GB |
refterms.dateFirstOnline | 2023-12-29 | |