Opioid medication use and blood DNA methylation: epigenome-wide association meta-analysis.
dc.contributor.author | Lee, M | |
dc.contributor.author | Joehanes, R | |
dc.contributor.author | McCartney, DL | |
dc.contributor.author | Kho, M | |
dc.contributor.author | Hüls, A | |
dc.contributor.author | Wyss, AB | |
dc.contributor.author | Liu, C | |
dc.contributor.author | Walker, RM | |
dc.contributor.author | R Kardia, SL | |
dc.contributor.author | Wingo, TS | |
dc.contributor.author | Burkholder, A | |
dc.contributor.author | Ma, J | |
dc.contributor.author | Campbell, A | |
dc.contributor.author | Wingo, AP | |
dc.contributor.author | Huan, T | |
dc.contributor.author | Sikdar, S | |
dc.contributor.author | Keshawarz, A | |
dc.contributor.author | Bennett, DA | |
dc.contributor.author | Smith, JA | |
dc.contributor.author | Evans, KL | |
dc.contributor.author | Levy, D | |
dc.contributor.author | London, SJ | |
dc.date.accessioned | 2023-03-29T10:26:55Z | |
dc.date.issued | 2023-01-26 | |
dc.date.updated | 2023-03-29T09:56:57Z | |
dc.description.abstract | Aim: To identify differential methylation related to prescribed opioid use. Methods: This study examined whether blood DNA methylation, measured using Illumina arrays, differs by recent opioid medication use in four population-based cohorts. We meta-analyzed results (282 users; 10,560 nonusers) using inverse-variance weighting. Results: Differential methylation (false discovery rate <0.05) was observed at six CpGs annotated to the following genes: KIAA0226, CPLX2, TDRP, RNF38, TTC23 and GPR179. Integrative epigenomic analyses linked implicated loci to regulatory elements in blood and/or brain. Additionally, 74 CpGs were differentially methylated in males or females. Methylation at significant CpGs correlated with gene expression in blood and/or brain. Conclusion: This study identified DNA methylation related to opioid medication use in general populations. The results could inform the development of blood methylation biomarkers of opioid use. | en_GB |
dc.description.sponsorship | National Institute of Health | en_GB |
dc.format.extent | 1479-1492 | |
dc.format.medium | Print-Electronic | |
dc.identifier.citation | Vol. 14, No. 23, pp. 1479-1492 | en_GB |
dc.identifier.doi | https://doi.org/10.2217/epi-2022-0353 | |
dc.identifier.grantnumber | Z01-ES043012 | en_GB |
dc.identifier.uri | http://hdl.handle.net/10871/132802 | |
dc.identifier | ORCID: 0000-0002-1060-4479 (Walker, Rosie M) | |
dc.identifier | ScopusID: 23029293000 (Walker, Rosie M) | |
dc.language.iso | en | en_GB |
dc.publisher | Future Medicine | en_GB |
dc.relation.url | https://www.ncbi.nlm.nih.gov/pubmed/36700736 | en_GB |
dc.relation.url | https://doi.org/10.5281/zenodo.7545108 | en_GB |
dc.rights | © 2023 National Institutes of Health. Open access: This work is licensed under the Creative Commons Attribution 4.0 License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ | en_GB |
dc.subject | blood | en_GB |
dc.subject | epigenetics | en_GB |
dc.subject | methylome | en_GB |
dc.subject | prescription opioids | en_GB |
dc.title | Opioid medication use and blood DNA methylation: epigenome-wide association meta-analysis. | en_GB |
dc.type | Article | en_GB |
dc.date.available | 2023-03-29T10:26:55Z | |
dc.identifier.issn | 1750-1911 | |
exeter.place-of-publication | England | |
dc.description | This is the final version. Available from Future Medicine via the DOI in this record. | en_GB |
dc.description | Data sharing statement: Complete meta-analysis results can be found at Zenodo 10.5281/zenodo.7545108. | en_GB |
dc.identifier.eissn | 1750-192X | |
dc.identifier.journal | Epigenomics | en_GB |
dc.relation.ispartof | Epigenomics, 14(23) | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | en_GB |
dcterms.dateAccepted | 2023-01-13 | |
dc.rights.license | CC BY-NC-ND | |
rioxxterms.version | VoR | en_GB |
rioxxterms.licenseref.startdate | 2023-01-26 | |
rioxxterms.type | Journal Article/Review | en_GB |
refterms.dateFCD | 2023-03-29T10:21:58Z | |
refterms.versionFCD | VoR | |
refterms.dateFOA | 2023-03-29T10:26:57Z | |
refterms.panel | A | en_GB |
refterms.dateFirstOnline | 2023-01-26 |
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This work is licensed under the Creative Commons Attribution 4.0 License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/