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Opioid medication use and blood DNA methylation: epigenome-wide association meta-analysis.

dc.contributor.authorLee, M
dc.contributor.authorJoehanes, R
dc.contributor.authorMcCartney, DL
dc.contributor.authorKho, M
dc.contributor.authorHüls, A
dc.contributor.authorWyss, AB
dc.contributor.authorLiu, C
dc.contributor.authorWalker, RM
dc.contributor.authorR Kardia, SL
dc.contributor.authorWingo, TS
dc.contributor.authorBurkholder, A
dc.contributor.authorMa, J
dc.contributor.authorCampbell, A
dc.contributor.authorWingo, AP
dc.contributor.authorHuan, T
dc.contributor.authorSikdar, S
dc.contributor.authorKeshawarz, A
dc.contributor.authorBennett, DA
dc.contributor.authorSmith, JA
dc.contributor.authorEvans, KL
dc.contributor.authorLevy, D
dc.contributor.authorLondon, SJ
dc.date.accessioned2023-03-29T10:26:55Z
dc.date.issued2023-01-26
dc.date.updated2023-03-29T09:56:57Z
dc.description.abstractAim: To identify differential methylation related to prescribed opioid use. Methods: This study examined whether blood DNA methylation, measured using Illumina arrays, differs by recent opioid medication use in four population-based cohorts. We meta-analyzed results (282 users; 10,560 nonusers) using inverse-variance weighting. Results: Differential methylation (false discovery rate <0.05) was observed at six CpGs annotated to the following genes: KIAA0226, CPLX2, TDRP, RNF38, TTC23 and GPR179. Integrative epigenomic analyses linked implicated loci to regulatory elements in blood and/or brain. Additionally, 74 CpGs were differentially methylated in males or females. Methylation at significant CpGs correlated with gene expression in blood and/or brain. Conclusion: This study identified DNA methylation related to opioid medication use in general populations. The results could inform the development of blood methylation biomarkers of opioid use.en_GB
dc.description.sponsorshipNational Institute of Healthen_GB
dc.format.extent1479-1492
dc.format.mediumPrint-Electronic
dc.identifier.citationVol. 14, No. 23, pp. 1479-1492en_GB
dc.identifier.doihttps://doi.org/10.2217/epi-2022-0353
dc.identifier.grantnumberZ01-ES043012en_GB
dc.identifier.urihttp://hdl.handle.net/10871/132802
dc.identifierORCID: 0000-0002-1060-4479 (Walker, Rosie M)
dc.identifierScopusID: 23029293000 (Walker, Rosie M)
dc.language.isoenen_GB
dc.publisherFuture Medicineen_GB
dc.relation.urlhttps://www.ncbi.nlm.nih.gov/pubmed/36700736en_GB
dc.relation.urlhttps://doi.org/10.5281/zenodo.7545108en_GB
dc.rights© 2023 National Institutes of Health. Open access: This work is licensed under the Creative Commons Attribution 4.0 License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/en_GB
dc.subjectblooden_GB
dc.subjectepigeneticsen_GB
dc.subjectmethylomeen_GB
dc.subjectprescription opioidsen_GB
dc.titleOpioid medication use and blood DNA methylation: epigenome-wide association meta-analysis.en_GB
dc.typeArticleen_GB
dc.date.available2023-03-29T10:26:55Z
dc.identifier.issn1750-1911
exeter.place-of-publicationEngland
dc.descriptionThis is the final version. Available from Future Medicine via the DOI in this record. en_GB
dc.descriptionData sharing statement: Complete meta-analysis results can be found at Zenodo 10.5281/zenodo.7545108.en_GB
dc.identifier.eissn1750-192X
dc.identifier.journalEpigenomicsen_GB
dc.relation.ispartofEpigenomics, 14(23)
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_GB
dcterms.dateAccepted2023-01-13
dc.rights.licenseCC BY-NC-ND
rioxxterms.versionVoRen_GB
rioxxterms.licenseref.startdate2023-01-26
rioxxterms.typeJournal Article/Reviewen_GB
refterms.dateFCD2023-03-29T10:21:58Z
refterms.versionFCDVoR
refterms.dateFOA2023-03-29T10:26:57Z
refterms.panelAen_GB
refterms.dateFirstOnline2023-01-26


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© 2023 National Institutes of Health. Open access: This work is licensed under the Creative Commons Attribution 4.0 License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
Except where otherwise noted, this item's licence is described as © 2023 National Institutes of Health. Open access: This work is licensed under the Creative Commons Attribution 4.0 License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/