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A systematic review of psychosocial functioning changes after gender-affirming hormone therapy among transgender people

dc.contributor.authorDoyle, DM
dc.contributor.authorLewis, TOG
dc.contributor.authorBarreto, M
dc.date.accessioned2023-04-14T15:29:23Z
dc.date.issued2023-05-22
dc.date.updated2023-04-14T15:04:49Z
dc.description.abstractThis systematic review assessed the state and quality of evidence for effects of gender-affirming hormone therapy on psychosocial functioning. Forty-six relevant journal articles (six qualitative, 21 cross-sectional, 19 prospective cohort) were identified. Gender-affirming hormone therapy was consistently found to reduce depressive symptoms and psychological distress. Evidence for quality of life was inconsistent, with some trends suggesting improvements. There was some evidence of affective changes differing for those on masculinizing versus feminizing hormone therapy. Results for self-mastery effects were ambiguous, with some studies suggesting greater anger expression, particularly among those on masculinizing hormone therapy, but no increase in anger intensity. There were some trends toward positive change in interpersonal functioning. Overall, risk of bias was highly variable between studies. Small samples and lack of adjustment for key confounders limited causal inferences. More high-quality evidence for psychosocial effects of gender-affirming hormone therapy is vital for ensuring health equity for transgender people.en_GB
dc.identifier.citationPublished online 22 May 2023en_GB
dc.identifier.doi10.1038/s41562-023-01605-w
dc.identifier.urihttp://hdl.handle.net/10871/132909
dc.identifierORCID: 0000-0002-6973-7233 (Barreto, Manuela)
dc.language.isoenen_GB
dc.publisherNature Researchen_GB
dc.rights© The Author(s) 2023. Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
dc.subjectGender-affirming hormone therapyen_GB
dc.subjecttransgenderen_GB
dc.subjectpsychosocial functioningen_GB
dc.subjectwellbeingen_GB
dc.subjectinterpersonal functioningen_GB
dc.subjectmooden_GB
dc.subjectangeren_GB
dc.titleA systematic review of psychosocial functioning changes after gender-affirming hormone therapy among transgender peopleen_GB
dc.typeArticleen_GB
dc.date.available2023-04-14T15:29:23Z
dc.identifier.issn2397-3374
dc.descriptionThis is the final version. Available on open access from Nature Research via the DOI in this recorden_GB
dc.identifier.journalNature Human Behaviouren_GB
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en_GB
dcterms.dateAccepted2023-04-12
dcterms.dateSubmitted2023-02-28
rioxxterms.versionVoRen_GB
rioxxterms.licenseref.startdate2023-04-12
rioxxterms.typeJournal Article/Reviewen_GB
refterms.dateFCD2023-04-14T15:04:52Z
refterms.versionFCDAM
refterms.dateFOA2023-05-31T14:03:17Z
refterms.panelAen_GB


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© The Author(s) 2023. Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
Except where otherwise noted, this item's licence is described as © The Author(s) 2023. Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/