Effects of exercise intensity on gut microbiome composition and function in people with type 2 diabetes
dc.contributor.author | Torquati, L | |
dc.contributor.author | Gajanand, T | |
dc.contributor.author | Cox, ER | |
dc.contributor.author | Willis, CRG | |
dc.contributor.author | Zaugg, J | |
dc.contributor.author | Keating, SE | |
dc.contributor.author | Coombes, JS | |
dc.date.accessioned | 2023-04-17T12:46:22Z | |
dc.date.issued | 2022-03-23 | |
dc.date.updated | 2023-04-17T12:25:00Z | |
dc.description.abstract | Exercise is positively associated with higher microbial diversity, but there is limited information on exercise intensity's effect on gut microbiome composition and function in clinical populations. This study examines whether different intensities of exercise exert differential effects on gut microbiome composition and function in low active people with type 2 diabetes. This is a sub-study of the Exercise for Type 2 Diabetes Study, a single centre, prospective, randomised controlled trial. Participants (n = 12) completed 8-weeks of combined aerobic and resistance moderate intensity continuous training (C-MICT) or combined aerobic and resistance high-intensity interval training (C-HIIT). Faecal samples were collected before and after intervention to measure gut microbiome composition and metabolic pathways (metagenome shotgun sequencing) and short-chain fatty acids. Post-exercise α-diversity was different between groups as was the relative abundance of specific taxa was (p < .05). Post-exercise relative abundance of Bifidobacterium, A. municiphila, and butyrate-producers Lachnospira eligens, Enterococcus spp., and Clostridium Cluster IV were higher at lower exercise intensity. Other butyrate-producers (from Eryspelothrichales and Oscillospirales), and methane producer Methanobrevibacter smithii were higher at higher exercise intensity. Pyruvate metabolism (ko00620),COG “Cell wall membrane envelope biogenesis” and “Unknown function” pathways were significantly different between groups and higher in C-MICT post-exercise. Differential abundance analysis on KO showed higher expression of Two-component system in C-HIIT. Transcription factors and “unknown metabolism” related pathways decreased in both groups. There were no significant between group changes in faecal short chain fatty acids. Exercise intensity had a distinct effect on gut microbiome abundance and metabolic function, without impacting short-chain fatty acid output. | en_GB |
dc.description.sponsorship | Biotechnology & Biological Sciences Research Council (BBSRC) | en_GB |
dc.description.sponsorship | Biotechnology & Biological Sciences Research Council (BBSRC) | en_GB |
dc.description.sponsorship | Centre for Research in Exercise and Physical Activity (The University of Queensland) | en_GB |
dc.format.extent | 1-12 | |
dc.format.medium | Print-Electronic | |
dc.identifier.citation | Vol. 23 (4), pp. 530-541 | en_GB |
dc.identifier.doi | https://doi.org/10.1080/17461391.2022.2035436 | |
dc.identifier.grantnumber | BB/J014400/1 | en_GB |
dc.identifier.grantnumber | BB/M009122/1 | en_GB |
dc.identifier.uri | http://hdl.handle.net/10871/132921 | |
dc.identifier | ORCID: 0000-0003-4896-7598 (Torquati, L) | |
dc.identifier | ScopusID: 57189066008 (Torquati, L) | |
dc.language.iso | en | en_GB |
dc.publisher | Taylor and Francis Group | en_GB |
dc.relation.url | https://www.ncbi.nlm.nih.gov/pubmed/35107058 | en_GB |
dc.rights | © 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use,distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the AcceptedManuscript in a repository by the author(s) or with their consent. | en_GB |
dc.subject | HIIT training | en_GB |
dc.subject | diabetes | en_GB |
dc.subject | gut microbiota | en_GB |
dc.subject | metabolism | en_GB |
dc.subject | metagenomics | en_GB |
dc.subject | taxonomic diversity | en_GB |
dc.title | Effects of exercise intensity on gut microbiome composition and function in people with type 2 diabetes | en_GB |
dc.type | Article | en_GB |
dc.date.available | 2023-04-17T12:46:22Z | |
dc.identifier.issn | 1746-1391 | |
exeter.place-of-publication | England | |
dc.description | This is the final version. Available from Taylor and Francis Group via the DOI in this record. | en_GB |
dc.identifier.eissn | 1536-7290 | |
dc.identifier.journal | European Journal of Sport Science (EJSS) | en_GB |
dc.relation.ispartof | Eur J Sport Sci, 23(4) | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | en_GB |
dc.rights.license | CC BY | |
rioxxterms.version | VoR | en_GB |
rioxxterms.licenseref.startdate | 2022-03-23 | |
rioxxterms.type | Journal Article/Review | en_GB |
refterms.dateFCD | 2023-04-17T12:35:03Z | |
refterms.versionFCD | VoR | |
refterms.dateFOA | 2023-04-17T12:46:23Z | |
refterms.panel | A | en_GB |
refterms.depositException | publishedGoldOA | |
refterms.dateFirstOnline | 2022-03-23 |
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Except where otherwise noted, this item's licence is described as © 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use,distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the AcceptedManuscript in a repository by the author(s) or with their consent.