Age-Related Differences in Ocular Features of a Naturalistic Free-Ranging Population of Rhesus Macaques
dc.contributor.author | Fernandes, AG | |
dc.contributor.author | Alexopoulos, P | |
dc.contributor.author | Burgos-Rodriguez, A | |
dc.contributor.author | Martinez, MI | |
dc.contributor.author | Ghassibi, M | |
dc.contributor.author | Leskov, I | |
dc.contributor.author | Brent, LJN | |
dc.contributor.author | Snyder-Mackler, N | |
dc.contributor.author | Danias, J | |
dc.contributor.author | Wollstein, G | |
dc.contributor.author | Higham, JP | |
dc.contributor.author | Melin, AD | |
dc.date.accessioned | 2023-06-05T10:57:14Z | |
dc.date.issued | 2023-06-01 | |
dc.date.updated | 2023-06-05T10:12:50Z | |
dc.description.abstract | PURPOSE: Rhesus macaques (Macaca mulatta) are the premier nonhuman primate model for studying human health and disease. We investigated if age was associated with clinically relevant ocular features in a large cohort of free-ranging rhesus macaques from Cayo Santiago, Puerto Rico. METHODS: We evaluated 120 rhesus macaques (73 males, 47 females) from 0 to 29 years old (mean ± SD: 12.6 ± 6.4) from September to December 2021. The ophthalmic evaluation included intraocular pressure (IOP) assessment, corneal pachymetry, biomicroscopy, A-scan biometry, automated refraction, and fundus photography after pupil dilation. The associations of age with the outcomes were investigated through multilevel mixed-effects models adjusted for sex and weight. RESULTS: On average, IOP, pachymetry, axial length, and automated refraction spherical equivalent were 18.37 ± 4.68 mmHg, 474.43 ± 32.21 µm, 19.49 ± 1.24 mm, and 0.30 ± 1.70 diopters (D), respectively. Age was significantly associated with pachymetry (β coefficient = -1.20; 95% confidence interval [CI], -2.27 to -0.14; P = 0.026), axial length (β coefficient = 0.03; 95% CI, 0.01 to 0.05; P = 0.002), and spherical equivalent (β coefficient = -0.12; 95% CI, -0.22 to -0.02; P = 0.015). No association was detected between age and IOP. The prevalence of cataracts in either eye was 10.83% (95% CI, 6.34-17.89) and was significantly associated with age (odds ratio [OR] = 1.20; 95% CI, 1.06-1.36; P = 0.004). Retinal drusen in either eye was observed in 15.00% (95% CI, 9.60-22.68) of animals, which was also significantly associated with age (OR = 1.14; 95% CI, 1.02-1.27; P = 0.020). CONCLUSIONS: Rhesus macaques exhibit age-related ocular associations similar to those observed in human aging, including decreased corneal thickness, increased axial length, myopic shift, and higher prevalence of cataract and retinal drusen. | en_GB |
dc.description.sponsorship | New Frontiers in Research Foundation | en_GB |
dc.description.sponsorship | Natural Sciences and Engineering Research Council | en_GB |
dc.description.sponsorship | Canada Research Chairs Program | en_GB |
dc.description.sponsorship | National Aging Institute | en_GB |
dc.description.sponsorship | BrightFocus Foundation | en_GB |
dc.description.sponsorship | National Institutes of Health (NIH) | en_GB |
dc.description.sponsorship | University of Calgary | en_GB |
dc.format.extent | 3- | |
dc.identifier.citation | Vol. 64(7), article 3 | en_GB |
dc.identifier.doi | https://doi.org/10.1167/iovs.64.7.3 | |
dc.identifier.grantnumber | NFRFE-2018-02159 | en_GB |
dc.identifier.grantnumber | RGPIN-2017-03782 | en_GB |
dc.identifier.grantnumber | 950-231257 | en_GB |
dc.identifier.grantnumber | 1R56AG071023 | en_GB |
dc.identifier.grantnumber | R01AG060931 | en_GB |
dc.identifier.grantnumber | G2020047 | en_GB |
dc.identifier.grantnumber | NIH R01-EY030770 | en_GB |
dc.identifier.uri | http://hdl.handle.net/10871/133293 | |
dc.identifier | ORCID: 0000-0002-1202-1939 (Brent, Lauren JN) | |
dc.language.iso | en | en_GB |
dc.publisher | Association for Research in Vision and Ophthalmology (ARVO) | en_GB |
dc.relation.url | https://www.ncbi.nlm.nih.gov/pubmed/37261386 | en_GB |
dc.rights | © 2023 The Authors. Open access. This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | en_GB |
dc.subject | aging | en_GB |
dc.subject | animal models | en_GB |
dc.subject | nonhuman primate | en_GB |
dc.subject | rhesus macaque | en_GB |
dc.title | Age-Related Differences in Ocular Features of a Naturalistic Free-Ranging Population of Rhesus Macaques | en_GB |
dc.type | Article | en_GB |
dc.date.available | 2023-06-05T10:57:14Z | |
dc.identifier.issn | 0146-0404 | |
exeter.place-of-publication | United States | |
dc.description | This is the final version. Available on open access from the Association for Research in Vision and Ophthalmology via the DOI in this record | en_GB |
dc.identifier.eissn | 1552-5783 | |
dc.identifier.journal | Investigative Ophthalmology & Visual Science | en_GB |
dc.relation.ispartof | Invest Ophthalmol Vis Sci, 64(7) | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | en_GB |
dcterms.dateAccepted | 2023-02-28 | |
rioxxterms.version | VoR | en_GB |
rioxxterms.licenseref.startdate | 2023-06-01 | |
rioxxterms.type | Journal Article/Review | en_GB |
refterms.dateFCD | 2023-06-05T10:53:10Z | |
refterms.versionFCD | VoR | |
refterms.dateFOA | 2023-06-05T10:57:19Z | |
refterms.panel | A | en_GB |
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