Transposable elements and xenobiotic resistance
dc.contributor.author | ffrench-Constant, RH | |
dc.date.accessioned | 2023-07-20T08:22:32Z | |
dc.date.issued | 2023-06-12 | |
dc.date.updated | 2023-07-19T15:22:37Z | |
dc.description.abstract | Transposable elements or TEs are well known drivers of adaptive change in plants and animals but their role in insecticide resistance remains poorly documented. This review examines the potential role of transposons in resistance and identifies key areas where our understanding remains unclear. Despite well-known model systems such as upregulation of Drosophila Cyp6g1, many putative examples lack functional validation. The potential types of transposon-associated changes that could lead to resistance are reviewed, including changes in up-regulation, message stability, loss of function and alternative splicing. Where potential mechanisms appear absent from the resistance literature examples are drawn from other areas of biology. Finally, ways are suggested in which transgenic expression could be used to validate the biological significance of TE insertion. In the absence of such functional expression studies many examples of the association of TEs and resistance genes therefore remain as correlations. | en_GB |
dc.description.sponsorship | Biotechnology and Biological Sciences Research Council (BBSRC) | en_GB |
dc.description.sponsorship | European Research Council (ERC) | en_GB |
dc.description.sponsorship | Leverhulme Trust | en_GB |
dc.description.sponsorship | Royal Society | en_GB |
dc.identifier.citation | Vol. 3, article 1178212 | en_GB |
dc.identifier.doi | https://doi.org/10.3389/finsc.2023.1178212 | |
dc.identifier.uri | http://hdl.handle.net/10871/133622 | |
dc.identifier | ORCID: 0000-0001-5385-9888 | 0000-0002-8704-2574 (ffrench-Constant, Richard H) | |
dc.language.iso | en | en_GB |
dc.publisher | Frontiers Media | en_GB |
dc.rights | © 2023 ffrench-Constant. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. | en_GB |
dc.subject | insecticide | en_GB |
dc.subject | resistance | en_GB |
dc.subject | transposable element | en_GB |
dc.subject | transposon | en_GB |
dc.subject | insect | en_GB |
dc.title | Transposable elements and xenobiotic resistance | en_GB |
dc.type | Article | en_GB |
dc.date.available | 2023-07-20T08:22:32Z | |
dc.identifier.issn | 2673-8600 | |
dc.description | This is the final version. Available on open access from Frontiers Media via the DOI in this record. | en_GB |
dc.identifier.journal | Frontiers in Insect Science | en_GB |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | en_GB |
dcterms.dateAccepted | 2023-05-24 | |
rioxxterms.version | VoR | en_GB |
rioxxterms.licenseref.startdate | 2023-06-12 | |
rioxxterms.type | Journal Article/Review | en_GB |
refterms.dateFCD | 2023-07-19T15:43:20Z | |
refterms.versionFCD | VoR | |
refterms.dateFOA | 2023-07-20T08:22:41Z | |
refterms.panel | A | en_GB |
refterms.dateFirstOnline | 2023-06-12 |
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Except where otherwise noted, this item's licence is described as © 2023 ffrench-Constant. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.